LACK OF CARCINOGENICITY OF 8-NITROQUINOLINE ON LONG-TERM IN VIVO TEST IN HAMSTERS
スポンサーリンク
概要
- 論文の詳細を見る
Syrian golden hamsters were administered 8-nitroquinoline, at a concentration of 0.05%, in a 10% ethanol solution as drinking water for 104 weeks. The animals were kept under observation until 112 weeks of age when the experiment was terminated. Both control and treated groups developed tumors in a pattern indistinguishable from that usually observed in Syrian golden hamsters. Thus the result of this experiment indicates that 8-nitroquinoline given orally at a concentration of 0.05% is not carcinogenic in Syrian golden hamsters.
- 日本トキシコロジー学会の論文
- 1985-05-25
著者
-
FURUKAWA Fumio
Division of Pathology, National Institute of Health Sciences
-
Hayashi Y
National Inst. Health Sci. Tokyo
-
Hayashi Yuzo
Department Of Pharmaceutical Sciences Kitasato University
-
Furukawa Fumio
Division Of Pathology National Institute Of Health Sciences
-
TAKAHASHI Michihito
Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences
-
HAYASHI Yuzo
Division of Pathology, National Institute of Health Sciences
-
TOYODA Kazuhiro
Division of Pathology
-
Hayashi Y
Division Of Pathology National Institute Of Health Sciences
-
KISHIMOTO Yoshio
Division of Pathology, National Institute of Hygienic sciences
-
SATOU Hidetaka
Division of Pathology, National Institute of Hygienic sciences
-
Satou Hidetaka
Division Of Pathology National Institute Of Hygienic Sciences
-
Takahashi Michihito
Division Of Pathology National Institute Of Health Sciences
-
Hayashi Y
Department Of Pharmaceutical Sciences Kitasato University
-
Hayashi Y
Department Of Pathology Tokyo Metropolitan Komagome Hospital
-
Toyoda K
Laboratory Of Plant Pathology And Genetic Engineering Graduate School Of Natural Science And Technol
-
Kishimoto Yoshio
Division Of Pathology National Institute Of Hygienic Sciences
-
Hayashi Yuzo
Division Of Pathology National Institute Of Hygienic Sciences
関連論文
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- LACK OF MODIFYING EFFECTS OF EUGENOL ON DEVELOPMENT OF LUNG PROLIFERATIVE LESIONS INDUCED BY URETHANE IN TRANS-GENIC MICE CARRYING THE HUMAN PROTOTYPE c-Ha-ras GENE
- Lack of a Dose-response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-Nitrosodiethylamine
- Enhancement by Cigarette Smoke Exposure of 2-Amino-3,8-dimethylimidazo [4,5-f] quinoxaline-induced Rat Hepatocarcinogenesis in Close Association with Elevation of Hepatic CYP1A2
- Prevention by 2-Mercaptoethane Sulfonate and N-Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate
- A SURVEY OF THE VALUES OF CLINICAL CHEMISTRY PARAMETERS OBTAINED FOR A COMMON RAT BLOOD SAMPLE IN NINETY-EIGHT JAPANESE LABORATORIES
- Effect of Cigarette Smoke on the Mutagenic Activation of Environmental Carcinogens by Rodent Liver.
- Effect of cigarette smoke on the mutagenic activation of various carcinogens in hamster.
- Involvement of Lipid Peroxidation in Spontaneous Pancreatitis in WBN/Kob Rats
- Allelic Loss of 14q and 22q, NF2 Mutation, and Genetic Instability Occur Independently of c-kit Mutation in Gastrointestinal Stromal Tumor
- MEN1 gene mutations in sporadic neuroendocrine tumors of foregut derivation
- Polymerase chain reaction screening of immunoglobulin heavy chain and T cell receptor γ gene rearrangements: A practical approach to molecular DNA analysis of non-Hodgkin's lymphoma in a surgical pathology laboratory
- Pyothorax-associated lymphoma : Development of Epstein-Barr virus-associated lymphoma within the inflammatory cavity
- Intracranial meningioma masquerading as a primary pleuropulmonary tumor
- THYROID PROLIFERATIVE LESIONS INDUCED BY ANTI-THYROID DRUGS IN RATS ARE NOT ALWAYS ACCOMPANIED BY SUSTAINED INCREASES IN SERUM TSH
- Renal Carcinogenicity of Concurrently Administered Fish Meal and Sodium Nitrite in F344 Rats
- Inhibition by β-Carotene of Upper Respiratory Tumorigenesis in Hamsters Receiving Diethylnitrosamine Followed by Cigarette Smoke Exposure
- IMMUNOHISTOCHEMICAL STUDIES OF TSH-PRODUCING CELLS IN THE PITUITARY AND EXPRESSION OF GROWTH FACTORS IN THYROIDAL PROLIF-ERATIVE LESIONS IN RATS TREATED WITH THIOUREA AND EXCESS VITAMIN A
- Sequential Demonstration of Lipid Peroxidation-related Biomolecules in Rat Livers Treated with Carbon Tetrachloride
- CARCINOGENIC SUSCEPTIBILITY OF HRAS2 TRANSGENIC MICE TO VINYL CARBAMATE AND RAS GENE MUTAIONS IN INDUCED LUNG TUMORS
- Enhancement of Skin Tumorigenesis Due to Subcutaneous Implantation of Polyurethane Sheets in Rats Treated with N-Methyl-N-nitrosourea
- Enhancing Effects of Quinacrine on Development of Hepatopancreatic Lesions in N-Nitrosobis (2-oxopropyl) amine-initiated Hamsters
- Mechanistic Insights into Chemopreventive Effects of Phenethyl Isothiocyanate in N-Nitrosobis (2-oxopropyl) amine-treated Hamsters
- "P-42 Protective Effect of Lecithinization-Superoxide Dismutase Against Monocrotaline Induced Lung Injuries
- "P-41 A Morphometric study on the time course change of thyrotroph hypertrophy in the pituitary of rats treated with a goitrogen.
- "P-34 Inhibitory Effects of 2-Mercaptoethane Sulfonate on the Development of Cholangiofibrosis in Rats induced by N-Nitrosopyrrolldine.
- "P-26 Long-term Effects of Cortisol Acetate on Rat Pancreas.
- "P-22 A Combination Toxicity Study of Sodium Ascorbate and Sodium Nitrite In Rats
- Chemopreventive Effects of 3-Phenylpropyl Isothiocyanate on Hamster Lung Tumorigenesis Initiated with N-Nitrosobis (2-oxopropyl) amine
- P-17 Sequential Observation of Acrolein-modified Protein and Effects of N-Acetylcysteins in Livers of Rats Treated with Carbon Tetrachloride.(Proceedings of the 27th Annual Meeting)
- P-14 Effects of antioxidants on spontaneous hepatic and renal lesions in LEC rats.(Proceedings of the 27th Annual Meeting)
- Lack of Modification by Environmental Estrogenic Compounds of Thyroid Carcinogenesis in Ovariectomized Rats Pretreated with N-bis(2-hydroxynronyl)nitrosamine (DHPN)
- Lack of Modifying Effects of Environmental Estrogenic Compounds on the Development of Thyroid Proliferative Lesions in Male Rats Pretreated with N-Bis(2-hydroxypropyl)nitrosamine(DHPN)
- Inhibitory Effects of 1'-Acetoxychavicol Acetate on N-Nitrosobis(2-oxopropyl)-amine-induced Initiation of Cholangiocarcinogenesis in Syrian Hamsters
- 21D-03-4 Effects of Josamycin on The Spontaneous Development of Pancreatic Lesions in WBN/Kob Rats.
- Concurrent Administration of Fish Meal and Sodium Nitrite Does not Promote Glandular Stomach Carcinogenesis in Rats after Treatment with N-methyl-N'-nitro-N-nitrosoguanidine
- 22D-10-1 Effects of Oltipraz on Spontaneous Hepatitis of LEC Rats.
- 21C-10-4 Effects of Combined Treatment with Antioxidants and Sodium Nitrite on the Rat Forestomach.
- INFLUENCES OF LONG-TERM ADMINISTRATION OF 24R, 25-DIHYDROXYVITAMIN D_3, A VITAMIN D_3 DERIVATIVE, IN RATS
- A pea NTPase, PsAPY1, recognizes signal molecules from microorganisms
- Identification of genes expressed during spore germination of Mycosphaerella pinodes
- Agrobacterium tumefaciens-mediated transformation as a tool for random mutagenesis of Colletotrichum trifolii
- Gramine Increase Associated with Rapid and Transient Systemic Resistance in Barley Seedlings Induced by Mechanical and Biological Stresses
- SYSTEMIC ACQUIRED RESISTANCE IN BARLEY SEEDLINGS
- Toxicity and Decomposition Potency of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone (MX) (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
- Phylogenetic Classification of Dof- type Transcription Factors in Pea (Pisum sativum)
- Molecular Cloning of cDNA for a Novel Pea Dof Protein, PsDof1, and Its DNA-Binding Activity to the Promoter of PsDof1 Gene
- Lack of Modifying Effects of NNK on Lung Tumorigenesis in Hamsters with Pulmonary Fibrosis Induced by MNUR
- Immunohistochemical demonstration of ornithine decarboxylase (ODC) expression in altered liver cell foci of rats treated with peroxisome proliferators.
- INFLUENCE OF LONG-TERM ADMINISTRATION OF A VITAMIN D3 ANALOGUE IN RATS
- STUDY ON MOUSE HAIR CYCLE : COMPARISON AMONG DIFFERENT STRAINS
- EFFECT OF METHYLENE DIPHOSPHONIC ACID TECHNETIUM ON THE INJURED BONE OF THE RAT
- DERMAL TOXICITY OF BUTYLATED HYDROXYTOLUENE (BHT) AND BUTYLATED HYDROXYANISOLE (BHA) IN MICE
- LACK OF CARCINOGENICITY OF 8-NITROQUINOLINE ON LONG-TERM IN VIVO TEST IN HAMSTERS
- CAPACITY FOR INDUCTION OF THYROID PROLIFERATIVE LESIONS BY ANTI-THYROID DRUGS WITH DIFFERENT TOXIC MECHANISMS
- TIME COURSE OBSERVATION OF THYROID PROLIFERATIVE LESIONS AND SERUM TSH LEVELS IN RATS TREATED WITH THIOUREA AFTER DHPN INITIATION
- "P-12 The effects of 90-day feeding of Aramite or other herbicides of diphenyl ether group on livers, gall-bladders and bile ducts in dogs.
- Sample surveillance for clinical pathology testing.
- Suppressors : Determinants of Specificity Produced by Plant Pathogens : MEMBRANES AND BIOENERGETICS : CELL-CELL INTERACTION
- Inhibition of ATPase Activity in Pea Plasma Membranes by Fungal Suppressors from Mycosphaerella pinodes and Their Peptide Moieties
- In vivo FOOTPRINTING ANALYSIS OF cis-REGULATORY ELEMENTS INVOLVED IN THE ELICITOR-MEDIATED ACTIVATION AND SUPPRESSOR-MEDIATED DEACTIVATION OF PEA PAL AND CHS
- ISOLATION AND CHARACTERIZATION OF ELICITOR-RESPONSIVE GENES IN PEA
- 21B-04-1 Preliminary Repeated Dose (28 Days) Oral Toxicity Study of Flutamide to Establish the Efficacy of the "Enhanced OECD Test Guideline 407" in Rats.
- CADMIUM ACCUMULATION IN RATS TREATED ORALLY WITH CADMIUM CHLORIDE FOR 8 MONTHS
- Report 5 : PROBLEMS IN INTERPRETATION OF CARCINOGENICITY STUDIES (CARCINOGENlClTY STUDIES)
- Improved Biocompatibility of Titanium-Zirconium (Ti-Zr) Alloy : Tissue Reaction and Sensitization to Ti-Zr Alloy Compared with Pure Ti and Zr in Rat Implantation Study
- Tissue Reactions and Sensitivity to Iron-Chromium Alloys
- A Method to Monitor Corrosion of Chromium-iron Alloys by Monitoring the Chromium Ion Concentration in Urine
- 2A-04 Mechanistic study on testicular toxicity in rats caused by nitrofurazone
- CONFIRMATION STUDY, USING NITROBENZENE, OF THE COMBINED REPEAT DOSE AND REPRODUCTIVE/DEVELOPMENTAL TOXICITY TEST PROTOCOL PROPOSED BY THE ORGANIZATION FOR ECONOMIC COOPERATION AND DEVELOPMENT (OECD)
- Sample surveillance for clinical pathology testing(2) Analysis of blood chemical data
- BLOOD OF RATS AND DOGS FOR USE AS SURVEILLANCE SAMPLES : INVESTIGATION OF STORAGE AND TRANSPORTATION CONDITIONS
- Blood group-related antigen expression in pancreatic lesions induced by N-nitrosobis(2-oxopropyl)amine in hamsters.
- MORPHOLOGICAL EVALUATION OF CYCLOPHOSPHAMIDE TESTICULAR TOXICITY IN RATS USING QUANTITATIVE MORPHOMETRY OF SPERMATOGENIC CYCLE STAGES
- TESTICULAR TOXICITY EVALUATION OF CYCLOPHOSPHAMIDE BY QUANTITATIVE MORPHOMETRY OF SPERMATOGENIC CYCLE STAGES
- Usage of ABD-F and SBD-F as Pre-chromatographic Labeling Reagents for the Simultaneous Determination of Thiols and Disulfides in Biological Specimens
- Induction of Defense Responses by Synthetic Glycopeptides that Have a Partial Structure of the Elicitor in the Spore Germination Fluid of Mycosphaerella Pinodes
- EFFECTS OF SYNTHETIC GLYCOPEPTIDE-ELICITORS ON DEFENSE RESPONSES OF PEA PLANTS
- A binding protein for fungal signal molecules in the cell wall of Pisum sativum
- CYTOTOXICITY AND SUPPRESSION OF CALCIUM RESPONSE BY TRIBUTYLTIN-TREATMENT IN PRIMARY CULTURED HEPATOCYTES
- Direct toxicity of ethane-1, 2-dimethanesulfonate to rat epididymis
- Suppression of Calcium Response to Hormonal Stimulation by Tributyltin in Primary Cultured Rat Hepatocytes
- INDEPENDENT PATHWAYS OF DEFENSE RESPONSES IN ELICITIN-TREATED TOBACCO BY-2 CELLS
- STUDY OF EXAMINATION METHODS FOR ASSESSING MALE FERTILITY DISTURBANCES 1.QUANTITATIVE MORPHOMETRICAL EVALUATION OF TESTICULAR TOXICITY OF ADRIAMYCIN
- PROBLEMS ON PATHOLOGICAL EXAMINATIONS
- Pea extracellular Cu/Zn-superoxide dismutase responsive to signal molecules from a fungal pathogen
- Effect of Harpin from Four Pathovars of Pseudomonas syringae on Pea Defense Responses (Short Communication)
- Plant Lectins Induce the Production of a Phytoalexin in Pisum sativum : CELL-CELL INTERACTION : NATURAL PRODUCTS
- Rapid Changes in Polyphosphoinositide Metabolism in Pea in Response to Fungal Signals
- LOCALIZATION OF 4-HYDROXYNONENAL, AN ALDEHYDIC LIPID PEROXIDATION PRODUCT, IN THE LIVER OF RATS TREATED WITH CARBON TETRACHLORIDE
- Localization and responsiveness of a cowpea apyrase VsNTPase1 to phytopathogenic microorganisms
- Regulation of Polyphosphoinositide Metabolism in Pea Plasma Membranes by Elicitor and Suppressor from a Pea Pathogen, Mycosphaerella pinodes
- USEFULNESS OF IN VIVO SHORT-TERM STUDIES ON CARCINOGENIC RISK ASSESSMENT
- Expression of the 12-Oxophytodienoic Acid 10,11-Reductase Gene in the Compatible Interaction between Pea and Fungal Pathogen
- A NOVEL QUANTITATIVE MORPHOMETRY OF GERM CELLS FOR THE HISTOPATHOLOGICAL EVALUATION OF RAT TESTICULAR TOXICITY
- EFFECTS OF TRYPSIN INHIBITORS ON PANCREATIC ATROPHY INDUCED BY BOP TREATMENT IN HAMSTERS
- 332 CELL PROLIFERATIVE ACTIVITIES OF CHOLANGIOFIBROSIS IN RATS INDUCED BY BROMODICHLOROMETHANE
- Lack of Modifying Effects of Cinnamaldehyde on Development of Lung Proliferative Lesions Induced by Urethane in Transgenic Mice Carrying the Human Prototype c-Ha-ras Gene
- Spontaneous Oscillations of Cytoplasmic Free Calcium Ion Concentration in Cultured Smooth Muscle Cells from Guinea Pig Ileum.
- The Relationship between Spontaneous Calcium Oscillations and Cell Proliferation in Cultured Smooth Muscle Cells.