Lack of Modifying Effects of Cinnamaldehyde on Development of Lung Proliferative Lesions Induced by Urethane in Transgenic Mice Carrying the Human Prototype c-Ha-ras Gene
スポンサーリンク
概要
- 論文の詳細を見る
- 2000-12-20
著者
-
ONODERA Hiroshi
Division of Pathology, National Institute of Health Sciences
-
TAKAGI Hisayoshi
Division of Pathology, National Institute of Health Sciences
-
Takizawa Tamotsu
Division Of Pathology National Institute Of Health
-
Takagi Hisayoshi
国立医薬品食品衛生研究所
-
Takagi Hisayoshi
Division Of Pathology National Institute Of Health Sciences
-
小野寺 博志
Division Of Pathology National Institute Of Health Sciences
-
糀谷 高敏
Division Of Pathology National Institute Of Health Sciences
-
Koujitani Takatoshi
国立医薬品食品衛生研究所
-
Koujitani Takatoshi
Division Of Pathology National Institute Of Health Sciences
-
Hayashi Y
National Inst. Health Sci. Tokyo
-
Makita Hiroki
岐阜大学 第1病理
-
Hirose Masao
Division Of Pathology National Institute Of Health Sciences
-
Mitsumori Kunitoshi
Division Of Pathology National Institute Of Health Sciences
-
Hayashi Y
Division Of Pathology National Institute Of Health Sciences
-
Matsumoto K
Drug Safety Research Laboratories Pharmaceutical Research Division Takeda Chemical Industries Ltd.:l
-
三森 国敏
Division Of Pathology National Institute Of Health Sciences
-
Hayashi Y
Department Of Pathology Tokyo Metropolitan Komagome Hospital
-
Kashida Y
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Matsumoto K
Laboratory Of Veterinary Pathology Tokyo University Of Agriculture And Technology
-
Yasuhara Kazuo
Division Of Medicinal Chemistry And Pharmacognosy Ohio State University
-
Hayashi Yuzo
Department Of Cardiology Kasugai Municipal Hospital
-
Tamura Toru
Division Of Pathology National Institute Of Health
関連論文
- A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats
- Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide
- Lack of modifying effects of prepubertal exposure to acrylamide (AA) on N-methyl-N-nitrosourea (MNU)-induced multi-organ carcinogenesis in F344 rats
- Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
- Inhibitory Effects of Octreotide Acetate, a Somatostatin Analog, on Spontaneous Chronic Pancreatitis in WBN/Kob Rats
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points
- DNA Adduct Formation, Nucleolar Segregation and Cell Proliferation in Rats Treated with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
- Depression of T cell-mediated immunity reduces sulfadimethoxine-induced capsular inflammation and inhibits associated development of invasive thyroid follicular cell carcinomas in rats
- Lack of enhancement of susceptibility to mammary and thyroid carcinogenesis in rats exposed to DMBA and DHPN following prepubertal iodine deficiency
- Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats
- In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate
- Comparison of enhancing effects of different goitrogen treatments in combination with β-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds
- Lack of Modifying Effects of Combined Treatment of t-butylhydroquinone and Sodium Nitrite on Forestomach Carcinogenesis in rasH2 Mice Initiated with N-ethyl-N-nitrosourea
- Tumorigenic Susceptibility of Catechol on the Gastric Mucosa in rasH2 Mice
- Lack of Modifying Effect of Glycerol in Pulmonary Carcinogenesis in rasH2 Mice Induced by Urethane or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
- LACK OF MODIFYING EFFECTS OF EUGENOL ON DEVELOPMENT OF LUNG PROLIFERATIVE LESIONS INDUCED BY URETHANE IN TRANS-GENIC MICE CARRYING THE HUMAN PROTOTYPE c-Ha-ras GENE
- Lack of Modifying Effects of Cinnamaldehyde on Development of Lung Proliferative Lesions Induced by Urethane in Transgenic Mice Carrying the Human Prototype c-Ha-ras Gene
- Modulatory effects of hepatic, renal or thyroidal impairments on amitrole-induced thyroid carcinogenesis in rats pretreated with DHPN (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Safety evaluetion of Bt protein by dietary administration to a gastro-intestinal impairment rat model (GENERAL TOXICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Promoting Effects of Ethinylestradiol but not Atrazine on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in ICR Mice
- Modifying Effects of 2,6-Dimethylaniline on Nasal Carcinogenesis in RasH2 Mice Initiated with 4-Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Lack of Modifying Effects of 2,6-Dimethylaniline on Lung Carcinogenesis in Transgenic Mice Carrying Human Prototype c-Ha-ras Gene Initiated with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone
- Difference in the Types of Uterine Tumors between Heterozygous p53-deficient and Wild Type CBA Mice Treated with Ethinylestradiol after N-ethyl-N-nitrosourea Initiation
- Modifying effect of atrazine on DMBA-induced mammary carcinogenesis in ovariectomized rats.(GENERAL SESSION BY POSTER PRESENTATION)(CARCINOGENICITY)
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- A Preliminary Study of the Effect of Plantago Ovata Forsk on the Development of 7, 12-Dimethylbenz[a]anthracene-initiated Rat Mammary Tumors under the Influence of Hypercholesterolemia
- Modifying Effects of Genistein, 4-Nonylphenol and Methoxychlor on N-ethyl-N-nitrosourea-induced Uterine Carcinogenesis in RasH2 Transgenic Mice Harboring a Human Prototype C-Ha-ras Gene
- Enhancing Effects β-Estradiol 3-Benzoate but Not Methoxychlor on the Promotion/Progression Stage of Chemically-induced Mammary Carcinogenesis in Ovariectomized Rats
- GONADAL TOXICITY OF AN ETHANOL EXTRACT OF PSORALEA CORYLIFOLIA IN A RAT 90-DAY REPEATED DOSE STUDY
- The Utility of N-nitrosamines as Initiators for a 26-Week Rat Two-Stage Nasal Carcinogenesis Model
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- N-bis(2-hydroxypropyl)nitrosamineを用いたラット二段階鼻腔発癌モデルにおける2, 6-dimethylaniline誘発鼻腔病変の経時的検討
- Significance of Cyclin D1 Overexpression and K-ras Point Mutations in Lung Tumors Induced by N-methyl-N-nitrosourethane in Hamsters
- Effects of Simultaneous Treatment with Excess Amounts of Vitamin A and Goitrogens on Thyroid Tumorigenesis in Rats
- EFFECT OF SIMULTANEOUS TREATMENT OF LARGE AMOUNTS OF VITAMIN A AND THIOUREA ON THYROIDAL IODINE UPTAKE AND ORGANIFICATION IN RATS
- RELATIONSHIP BETWEEN PULMONARY FIBROSIS AND LUNG PROLIFERATIVE LESIONS INDUCED BY DIFFERENT DOSES OF N-METHYL-N-NITROSOURETHANE IN SYRIAN GOLDEN HAMSTERS
- ENHANCEMENT OF RAT THYROID PROLIFERATIVE LESION DEVELOPMENT BY STEP-WISE INCREASING DOSE TREATMENT WITH SULFADIMETHOXINE
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Inhibiting Effects of Ethinylestradiol on N-ethyl-M-nitrosourea-Initiated Uterine Carcinogenesis in Transgenic Mice Carrying a Human Prototype C-Ha-ras Gene (rasH2 mice) (CARCINOGENICITY) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th A
- Development of invasive follicular cell carcinomas in a rat thyroid carcinogenesis model : Biological impact of capsular inflammation and reduced cyclooxygenase-2 expression
- A SURVEY OF THE VALUES OF CLINICAL CHEMISTRY PARAMETERS OBTAINED FOR A COMMON RAT BLOOD SAMPLE IN NINETY-EIGHT JAPANESE LABORATORIES
- Induction of Squamous Cell Carcinomas in the Salivary Glands of Rats by Potassium Iodide
- Possible enhancing effects of atrazine on growth of 7, 12-dimethylbenz(a) anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats
- Safety assessment of biopharmaceuticals : Japanese perspective on ICH S6 guideline maintenance
- Points to consider on the non-clinical safety evaluation of anticancer drugs
- CURRENT OPINION : SAFETY EVALUATION OF DRUG METABOLITES IN DEVELOPMENT OF PHARMACEUTICALS
- "POINTS TO CONSIDER" REGARDING SAFETY ASSESSMENT OF BIOTECHNOLOGY-DERIVED PHARMACEUTICALS IN NON-CLINICAL STUDIES (ENGLISH TRANSLATION)
- THYROID PROLIFERATIVE LESIONS INDUCED BY ANTI-THYROID DRUGS IN RATS ARE NOT ALWAYS ACCOMPANIED BY SUSTAINED INCREASES IN SERUM TSH
- Renal Carcinogenicity of Concurrently Administered Fish Meal and Sodium Nitrite in F344 Rats
- TIME COURSE OBSERVATION OF THYROID PROLIFERATIVE LESIONS AND SERUM LEVELS OF RELATED HORMONES IN RATS TREATED WITH KOJIC ACID AFTER DHPN INITIATION
- IMMUNOHISTOCHEMICAL STUDIES OF TSH-PRODUCING CELLS IN THE PITUITARY AND EXPRESSION OF GROWTH FACTORS IN THYROIDAL PROLIF-ERATIVE LESIONS IN RATS TREATED WITH THIOUREA AND EXCESS VITAMIN A
- CARCINOGENIC SUSCEPTIBILITY OF HRAS2 TRANSGENIC MICE TO VINYL CARBAMATE AND RAS GENE MUTAIONS IN INDUCED LUNG TUMORS
- "P-42 Protective Effect of Lecithinization-Superoxide Dismutase Against Monocrotaline Induced Lung Injuries
- "P-41 A Morphometric study on the time course change of thyrotroph hypertrophy in the pituitary of rats treated with a goitrogen.
- Chemopreventive Effects of 3-Phenylpropyl Isothiocyanate on Hamster Lung Tumorigenesis Initiated with N-Nitrosobis (2-oxopropyl) amine
- Granular Cell Tumors of the Female Reproductive Tract in Wistar Rats
- Lack of Modifying Effects of NNK on Lung Tumorigenesis in Hamsters with Pulmonary Fibrosis Induced by MNUR
- DEVELOPMENT OF A TOXICOLOGIC PATHOLOGY SYSTEM USING PERSONAL COMPUTER NETWORK
- STUDY ON MOUSE HAIR CYCLE : COMPARISON AMONG DIFFERENT STRAINS
- EFFECT OF METHYLENE DIPHOSPHONIC ACID TECHNETIUM ON THE INJURED BONE OF THE RAT
- DERMAL TOXICITY OF BUTYLATED HYDROXYTOLUENE (BHT) AND BUTYLATED HYDROXYANISOLE (BHA) IN MICE
- LACK OF CARCINOGENICITY OF 8-NITROQUINOLINE ON LONG-TERM IN VIVO TEST IN HAMSTERS
- DOSE-THRESHOLD FOR THYROID TUMOR-PROMOTING EFFECTS OF ORALLY AMINISTERED KOJIC ACID IN RATS AFTER INITIATION WITH N-bis(2-HYDROXYPROPYL) NITROSAMINE
- CAPACITY FOR INDUCTION OF THYROID PROLIFERATIVE LESIONS BY ANTI-THYROID DRUGS WITH DIFFERENT TOXIC MECHANISMS
- TIME COURSE OBSERVATION OF THYROID PROLIFERATIVE LESIONS AND SERUM TSH LEVELS IN RATS TREATED WITH THIOUREA AFTER DHPN INITIATION
- RELATIONSHIP BETWEEN INDUCTION-DOSES OF THYROID TUMORS BY ANTI-THYROID DRUGS AND PLASMA LEVELS OF T_3, T_4 AND TSH
- P-39 Effect of t-buthylhydroquinone and sodium nitrite alone or in combination on the forestomach of rasH2 mice.(Proceedings of the 27th Annual Meeting)
- P-38 Carcinogenic susceptibility of phenolphthalein in heterozygous p53 deficient C57BL/6 and CBA mice.(Proceedings of the 27th Annual Meeting)
- TOXICITY AND BLOOD CONCENTRATIONS OF XYLAZINE AND ITS METABOLITE, 2, 6-DIMETHYLANILINE, IN RATS AFTER SINGLE OR CONTINUOUS ORAL ADMINISTRATIONS
- 21B-04-1 Preliminary Repeated Dose (28 Days) Oral Toxicity Study of Flutamide to Establish the Efficacy of the "Enhanced OECD Test Guideline 407" in Rats.
- 21C-11-2 Modifying Effects of Xylazine on Rat Nasal Carcinogenesis.
- 21WA-01-4 Modifying Effects of Endocrine Disrupting Chemicals to Thyroid Proliferative Lesions in Ovariectomized Rats.
- Absence of Tumor Promoting Activity of Xylazine in a Two-stage Nasal Carcinogenesis Model in N-bis(2-hydroxypropyl)nitrosamine-treated Rats
- O11-12 Modifying effects of endocrine disrupting chemicals on ENU-induced uterine carcinogenesis in heterozygous p53 deficient CBA mice.
- P-67 Early changes of thyroid and in rats given a single administration of diisopropanolnitrosamine.(Proceedings of the 27th Annual Meeting)
- O-14 Mechanistic studies on testicular toxicity of Psoralea corylifolia extract in rats.(Proceedings of the 27th Annual Meeting)
- 21C-10-3 Susceptibility of p53 heterozygous knockout CBA mice to carcinogenic substances.
- 3A-19 A Mechanistic Study on Ovarian Carcinogenesis of Nitrofurazone in Mice
- 3A-16 Toxicological significance of the metabolite, 2,6-xylidine, in rats treated with a parent drug, xylazine
- 3A-06 Study on the Thyroid Tumor Promotion Effect of Kojic Acid
- CONFIRMATION STUDY, USING NITROBENZENE, OF THE COMBINED REPEAT DOSE AND REPRODUCTIVE/DEVELOPMENTAL TOXICITY TEST PROTOCOL PROPOSED BY THE ORGANIZATION FOR ECONOMIC COOPERATION AND DEVELOPMENT (OECD)
- BLOOD OF RATS AND DOGS FOR USE AS SURVEILLANCE SAMPLES : INVESTIGATION OF STORAGE AND TRANSPORTATION CONDITIONS
- Prevention of Stroke by a Japanese Traditional Medicine, Shichimotsu-koka-to, in Stroke-Prone Spontaneously Hypertensive Rats-a Histopathological Study
- Preventive Effects of Shinchimotsu-koka-to on Renal Lesions in Stroke-Prone Spontaneously Hypertensive Rats
- MORPHOLOGICAL EVALUATION OF CYCLOPHOSPHAMIDE TESTICULAR TOXICITY IN RATS USING QUANTITATIVE MORPHOMETRY OF SPERMATOGENIC CYCLE STAGES
- TESTICULAR TOXICITY EVALUATION OF CYCLOPHOSPHAMIDE BY QUANTITATIVE MORPHOMETRY OF SPERMATOGENIC CYCLE STAGES
- SPONTANEOUS OVARIAN CHORIOCARCINOMA IN TWO B6C3F_1 MICE
- Usage of ABD-F and SBD-F as Pre-chromatographic Labeling Reagents for the Simultaneous Determination of Thiols and Disulfides in Biological Specimens
- STUDY OF EXAMINATION METHODS FOR ASSESSING MALE FERTILITY DISTURBANCES 1.QUANTITATIVE MORPHOMETRICAL EVALUATION OF TESTICULAR TOXICITY OF ADRIAMYCIN
- 遺伝子組換えとうもろこしCBH351のBNラット並びにB10Aマウスへの90日間混餌投与による免疫系への影響
- SPONTANEOUS MESOTHELIOMAS IN F344 RATS : A LIGHT AND ELECTRON MICROSCOPICAL STUDY
- Prevention of Stroke by a Japanese Traditional Medicine, Shichimotsu-koka-to, in Stroke-Prone Spontaneously Hypertensive Rats : a Histopathological Study
- Perspectives on non-clinical safety evaluation of drug metabolites through the JSOT workshop
- Susceptibility of Heterozygous p53 Deficient CBA Mice to Induction of Liver Proliferative Lesions by Phenobarbital after Dimethylnitrosamine Initiation
- Modifying Effects of Endocrine Disrupting Chemicals on N-bis (2-hydroxypropyl) Nitrosamine and Sulfadimethoxine-Induced Thyroid Carcinogenesis in Rats
- Lack of Modifying Effects of Cinnamaldehyde on Development of Lung Proliferative Lesions Induced by Urethane in Transgenic Mice Carrying the Human Prototype c-Ha-ras Gene
- Modifying Effects of Flumequine on Dimethylnitrosamine-Induced Hepatocarcinogenesis in Heterozygous p53 Deficient CBA Mice
- Lack of Modifying Effects of Bisphenol A and Roasted-Ground Soybean (Kinako) on N-ethyl-N-nitrosourea-Induced Uterine Carcinogenesis in Heterozygous p53 Deficient CBA Mice
- Liver Tumor Promoting Effects of Febantel in a Two-stage Hepatocarcinogenesis Model of Rats Using D-galactosamine and Diethylnitrosamine.