Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points

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概要

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• This study was designed to rapidly screen for chemopreventive effects of three natural products, cyanidine-3-glycoside, acetoside and rosemaric acid, against 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP)-induced colonic, pancreatic and prostatic carcinogenesis in rats, using DNA adduct and cell proliferation as end-points. Ten-week-old F344 male rats were maintained for 2 weeks on a powdered basal diet containing 0.03% PhIP alone, PhIP together with 1% or 5% cyanidine-3-glycoside, acetoside or rosemaric acid, 1% or 5% cyanidine-3-glycoside, acetoside or rosemaric acid alone or basal diet. Immunohistochemically, PhIP DNA adduct-positive cells as well as BrdU-positive cells induced by PhIP treatment were significantly (P<0.05) reduced by the combined treatment with 5% cyanidine-3-glycoside in the proximal colon and pancreatic acinar cells as compared to the PhIP alone group values. In addition, combined treatment with 5% cyanidine-3-glycoside significantly (P<0.05) decreased numbers of BrdU-positive cells in the ventral prostate. Combined treatment with 5% rosemaric acid also significantly (P<0.05) reduced PhIP DNA adduct-positive cells in the proximal and distal colon, and ventral prostate as well as BrdU-positive cells in the lateral prostate and exocrine pancreas at 5%, and in the distal colon with 1% or 5%. However, co-treatment with acetoside did not significantly affect these parameters under the present experimental conditions. These results suggest that cyanidine-3-glycoside and rosemaric acid may have the potential to prevent PhIP-induced carcinogenesis in the colon, prostate and/or pancreas.

• 日本毒性病理学会の論文
• 2007-03-30

著者

• Umemura T

  Division Of Pathology National Institute Of Health Sciences

• Hirose Masao

  Division of Pathology, National Institute of Health Sciences

• Nishikawa Akiyoshi

  Division of Pathology, National Institute of Health Sciences

• Mori H

  Division Of Pathology National Institute Of Health Sciences

• UMEMURA Takashi

  Division of Pathology, National Institute of Health Sciences

• IMAZAWA Takayoshi

  Division of Pathology, National Institute of Health Sciences

• YOSHIMURA Yoshihiro

  Department of Analytical Chemistry, Hoshi University

• Hirose Masao

  国立医薬品食品衛生研究所 病理

• Hirose M

  Division Of Pathology National Institute Of Health Sciences:food Safety Commission

• Hirose Masao

  国立医薬品食品衛生研究所 病理部

• Hirose Masao

  名古屋市立大学 医学研究科実験病態病理学

• Imazawa T

  Division Of Pathology National Institute Of Health Sciences

• Imazawa Takayoshi

  国立医薬品食品衛生研究所 病理部

• Hoshi Manabu

  大阪市立大学 医学部病理学

• Mori Hideki

  岐阜薬科大学 生物薬学研究所

• Makita Hiroki

  岐阜大学 第1病理

• Hirose Masao

  Division Of Pathology National Institute Of Health Sciences

• Hirose Masao

  Div. Pathol. Natl. Inst. Htlh. Sci.

• Hirota M

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University

• Nishikawa A

  Div. Of Pathology National Inst. Of Health Sciences

• Nishikawa Akiyoshi

  Division Of Pathology Biology Safety Research Center National Institute Of Health Sciences

• Nishikawa A

  National Inst. Health Sci. Tokyo Jpn

• Yoshimura Yoshihiro

  Department Of Analytical Chemistry Hoshi University

• Yoshimura Yoshihiro

  Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University

• Hosono M

  Aburahi Laboratories Shionogi Research Laboratories Shionogi Co Ltd.

• Nishikawa A

  National Institute Of Health Science Osaka Branch National Institute Of Health Sciences

• Umemura Takashi

  Division Of Pathology National Institute Of Health Sciences

• Imazawa Takayoshi

  Division Of Pathology Biological Safety Research Center National Institute Of Health Sciences

• Mori Hideki

  College Of Engineering Graduate School Of Osaka Prefecture University

• Hirose Masao

  Department Of Pathology Nagoya Higashi Municipal Hospital

• Unno Takashi

  Division Of Pathology National Institute Of Health Sciences

• Umemura T

  Hokkaido Univ. Sapporo Jpn

• Umemura Takashi

  Division Of Pathology National Institute Of Health Science

• Unno Takashi

  Japan Pharmaceutical Manufactures Association (jpma):kanebo Ltd

• Ikeda Takako

  Division Of Pathology National Institute Of Health Sciences

• Mori Hideki

  First Department Of Pathology Gifu University School Of Medicine

• Umemura Takashi

  Laboratory Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University

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