Comparison of Antibody Titers in Rabbits Following Immunization with Inactivated Influenza Virus via Subarachnoidal or Subcutaneous Route
スポンサーリンク
概要
- 論文の詳細を見る
Rabbits were immunized with inactivated influenza virus via the subarachnoidal (SA) or subcutaneous (SC) route, and the antibody titers in cerebrospinal fluid (CSF) and serum were assayed. There were no nervous signs or morphological lesions related to SA immunization. In the SC group, the antibody titer was elevated in serum, but not elevated in CSF. In the SA group, the antibody titer was significantly elevated in serum and even in CSF, and their antibody titers were much greater than in the SC group. The present results suggest that intrathecal immunization is more effective than SC immunization at inducing a protective immune response against the transneural spread of viruses.
- 社団法人 日本獣医学会の論文
- 2007-11-25
著者
-
Umemura T
Division Of Pathology National Institute Of Health Sciences
-
SAKODA Yoshihiro
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, H
-
Ochiai Kenji
Hokkaido Univ. Sapporo Jpn
-
Ochiai Kenji
Department Of Applied Chemistry Graduate School Of Engineering Nagoya University:(present Address)ba
-
Ochiai Kenji
Laboratory Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University
-
Ochiai Kenji
Laboratory Of Comparative Pathology Department Of Veterimary Sciences Graduate School Of Veterimary
-
UMEMURA Takashi
Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine
-
Sakoda Yoshihiro
Hokkaido Univ. Sapporo Jpn
-
Sakoda Yoshihiro
Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
-
KIM Jae
Laboratory of Cellular Physiology and Immunology, and Chris Browne Center for Immunology and Immune
-
Unno Takashi
Division Of Pathology National Institute Of Health Sciences
-
Umemura Takashi
Laboratory Of Comparative Pathology Department Of Veterinary Clinical Sciences Graduate School Of Ve
-
Unno Takashi
Japan Pharmaceutical Manufactures Association (jpma):kanebo Ltd
-
SHIN Jae-Ho
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
-
Kim Jae
Laboratory Of Veterinary Pathology Department Of Veterinary Medicine Cheju National University
関連論文
- ナミハリネズミにおける乳腺癌と別種の悪性腫瘍の異時性発生(病理学)
- ライソゾーム酸性β-ガラクトシダーゼ欠損の柴犬における臨床症状および臨床病理学的特徴 : ヒトGMlガングリオシドーシスのイヌモデル
- 乳飲みマウス脳継代はウマヘルペスウイルス1型の末梢組織における増殖と中枢神経系への血行性伝播を増強する
- Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
- Rapid Screening for Chemopreventive Agents in Herbal Extracts in a PhIP Rat Model with DNA Adduct and Cell Proliferation as End-Points
- DNA Adduct Formation, Nucleolar Segregation and Cell Proliferation in Rats Treated with 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
- In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate
- Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine : Possible contribution of nitric oxide-associated oxidative DNA damage
- In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine(Mutagenicity, Carcinogenicity, Proceedings of the 32nd Annual Meeting)
- Catechol enhanced mice hepatotoxicity treated with acetaminophen(Liver, Alimentary system, Proceedings of the 32nd Annual Meeting)
- Lack of Initiating Activity of Kojic Acid on Hepatocarcinogenesis in F344 Rats
- P8-27 Susceptibility to pentachlorophenol, a mouse liver carcinogen in Nrf2-deficient mice(CIRCULATORY SYSTEM-2/ACTIVE OXYGEN)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Neospora caninumはヌードマウスに消化器病変を引き起こし, 感染ヌードマウス腸内容の腹腔内投与により他のマウスに伝達できる(短報)
- 融雪剤中毒が疑われた2005-2006年冬季北海道における野鳥の大量死(病理学)
- 神経膠腫誘発トリ白血病ウイルスの国内拡散と分離ウイルスに見られたenv遺伝子の変異(病理学)
- 不活化インフルエンザウイルスをクモ膜下および皮下接種されたウサギにおける抗体価の比較(免疫学)
- 糖質コルチコイド治療で長期寛解が得られた肉芽腫性髄膜脳炎罹患チワワの1例
- マウスおよび鶏におけるインフルエンザウイルス性脳炎発生への解熱剤投与の影響(病理学)
- 再燃を含む異なる病期におけるマウスIgGによって認識されるNeospor caninumの抗原(短報)(寄生虫病学)
- ステロイドホルモンは卵巣を摘出したNeospora caninum感染マウスにおいて原虫を再活性化しない(寄生虫病学)
- いわゆるトリの神経膠腫に関連して見られた非化膿性心筋炎
- 肝外胆管結紮を行ったブロイラー鶏の肝臓における伊東細胞 (脂肪摂取細胞) の免疫組織化学的ならびに電子顕微鏡学的研究
- ウシ白血病ウイルス感染腫瘍細胞に対する毒素遺伝子封入陽性荷電リポソームのin vivoにおける抗腫瘍効果(短報)
- 水鳥の鉛中毒症
- サラブレッド種の1子馬に発生したPneumocystis carinii肺炎(短報)
- 犬ジステンパーウイルスと犬伝染性肝炎ウイルスに重感染した1仔犬の病理(短報)
- E. cuniculiに対する直接ABC免疫組織化学
- ヌードマウスにおける地方病性牛白血病移植腫瘍に対する単クローン性抗体の抗腫瘍効果
- 犬の歯原性嚢胞の3症例:歯原性角化嚢胞の1例と含歯性嚢胞の2例(短報)(外科学)
- ノカルジア感染による肉芽腫性皮膚炎の犬の1例
- P6-43 Screening of chemopreventive agents using a medium-term pancreas carcinogenesis model in hamsters(DRUG METABOLISM/CARCINOGENICITY)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)
- Dose-related changes of oxidative stress and cell proliferation in kidneys of male and female F344 rats exposed to potassium bromate
- Enhancement of urinary bladder carcinogenesis by combined treatment with benzyl isothiocyanate and N-butyl-N-(4-hydroxybutyl) nitrosamine in rats after initiation
- A possible role of oxidative stress in potassium bromate (KBrO_3) carcinogenesis (ACTIVE OXYGEN) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)
- Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl) nitrosamine
- Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis : Results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine
- In vivo Approaches to Study Mechanism of Action of Genotoxic Carcinogens
- Mechanistic study on hepatocarcinogenesis induced by dicyclanil in mice : possible involvement of oxidative stress(Proceedings of the 32nd Annual Meeting)
- The Mouse rasH2/BHT Model as an in vivo Rapid Assay for Lung Carcinogens
- Prevention by 2-Mercaptoethane Sulfonate and N-Acetylcysteine of Renal Oxidative Damage in Rats Treated with Ferric Nitrilotriacetate
- 3A-08 A Chronic Inhalation Study of p-Dichlorobenzene in the F344 Rat
- A SURVEY OF THE VALUES OF CLINICAL CHEMISTRY PARAMETERS OBTAINED FOR A COMMON RAT BLOOD SAMPLE IN NINETY-EIGHT JAPANESE LABORATORIES
- Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
- Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice
- 下顎骨に強い骨増生を認めた扁平上皮癌の雑種猫の2例
- 膀胱全摘および尿管-尿道吻合により治療した膀胱癌のイヌの1症例
- 呼吸不全を伴った頚髄髄膜腫のイヌの一治験例
- Evaluation of the Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) as a Screening Method for the Detection of Influenza Viruses in the Fecal Materials of Water Birds
- "P-22 A Combination Toxicity Study of Sodium Ascorbate and Sodium Nitrite In Rats
- COMPARISON BETWEEN CRITICAL SHEAR RATES FOR FLOW-INDUCED HOMOGENIZATION OF POLYMER BLEND STUDIED BY RHEOMETRY AND FLOW-LIGHT SCATTERING
- Plateau Modulus of Homogeneous Polystyrene/Poly(vinyl methyl ether) Blends
- Viscoelastic Properties of Deep-Quenched Polymer Blends under Steady Shear Flow
- TOXICITY STUDY OF A RUBBER ANTIOXIDANT, 2-MERCAPTOBENZIMIDAZOLE, BY REPEATED ORAL ADMINISTRATION TO RATS
- 犬の鼻腔内に発生した未分化癌の病理学的検索
- A 13-WEEK TOXICITY STUDY OF SIMULTANEOUS ADMINISTRATION OF COCHINEAL AND ALUMINUM POTASSIUM SULFATE IN RATS
- Impaired Myelinogenesis and Early Maturation of Oligodendrocytes in Black Tremor Hamster with Central Nervous System Myelin Deficiency
- Sustained hypomyelination and high serum thyroid hormone in aged black tremor hamster
- "P-12 The effects of 90-day feeding of Aramite or other herbicides of diphenyl ether group on livers, gall-bladders and bile ducts in dogs.
- Sample surveillance for clinical pathology testing.
- B-22 A 28-DAY REPEATED DOSE TOXICITY TEST AND THE TIME COURSE OF CHOLINESTERASE ACTIVITY TEST FOR CHLORPYRIFOS IN WISTAR RAT
- B38 COMPARISON OF TOXICITY OF p-DCB IN MALE AND FEMALE RATS
- Development of an Immunochromatographic Kit for Rapid Diagnosis of H5 Avian Influenza Virus Infection
- "P-35 Contribution of Oxidative Stress to Rat Hepatotoxicity induced by 2-Nitropropane : Lipid Peroxidation and Inhibitory Effect of Green Tea.
- COMRARISON OF TOXICITY OF p-DICHLOROBENZENE (p-DCB) GIVEN ORALLY AND BY INHALATION
- O-55 HEMATOTOXICICOLOGIC CHARACTERISTICS FOR OXIDATIVE STRESSES INTRANSGENIC AND/OR KNOCK-OUT MICE FOR THIOREDOXIN/ADF GENE.(Proceedings of the 27th Annual Meeting)
- 21B-10-4 Benzene hemopoietic toxicity revisited- a new concept.
- 3A-09 Hemopoietic Stem-Cell Kinetics Evaluated by Bromodeoxyuridine Incorporation Followed by Near-UV Exposure to Kill Cycling Stem Cells (BUUV). 2) Bone Marrow Cells from Mice Carrying Human c-myc Proto-Oncogene with Promoters Combined with Immunoglobuli
- "P-8 Experimental myelodysplasia induced by Azidothymidine (AZT) : Hemopoietic Stem Cell Kinetics And Pathological Findings.
- Sample surveillance for clinical pathology testing(2) Analysis of blood chemical data
- Propagation of Swine Hemagglutinating Encephalomyelitis Virus and Pseudorabies Virus in Dorsal Root Ganglia Cells
- Effective Prevention against Rabies by Intracerebral Immunization in Mice
- 28-DAY REPEATED-DOSE ORAL TOXICITY STUDY OF 2-MERCAPTOBENZIMIDAZOLE, A RUBBER ANTIOXIDANT, IN RATS
- A 14-WEEK ORAL TOXICITY STUDY OF TRIBUTOXYETHYL PHOSPHATE(TBEP) IN RATS
- Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
- "B-3 Toxicokinetic Study of 2-Mercaptobenzimidazole (MBI) and its Methylated Derivative (MMBI) in Rats after Single Oral-Dose Administration.
- 22D-11-3 Increased Liver and Kidney Toxicities in Rats Caused by Co-administration of 2-Mercaptobenzimidazole (MBI) and Lipopolysaccharide (LPS) and Their Toxicokinetics (TK).
- Chronic cadmium treatment induces islet B cell injury in ovariectomized cynomolgus monkeys
- P10-16 Increased osteoid volume and iron deposition of the Iumbar vertebra in a chronic cadmium toxicosis model of cynomolgus monkeys.
- 21D-04-1 Quantitative Analysis of Bone Lesion in Ovariectomized Cynomolgus Monkeys Given Repeated Intravenous Injections of CdCl_2.
- Comparison of Antibody Titers in Rabbits Following Immunization with Inactivated Influenza Virus via Subarachnoidal or Subcutaneous Route
- Efficacy of Intracerebral Immunization against Pseudorabies Virus in Mice
- SUSPECTED NUTRITIONAL MYOPATHY IN TWO CAPTIVE BENNETT'S WALLABIES (MACROPUS RUFOGRISEUS)
- LEAD POISONING IN WATERFOWL
- STUDIES ON ANTITUMOR EFFECT IN NUDE MICE BEARING TUMORS BY MONOCLONAL ANTIBODY AGAINST TUMOR-ASSOCIATED ANTIGEN OF BOVINE LEUKOSIS AND THE MONOCLONAL ANTIBODY CONJUGATED TO ADRIAMYCIN ENTRAPPED IN LIPOSOMES
- In vitro demonstration of neural transmission of avian influenza A virus
- Laboratory of Comparative Pathology
- Cleavage of the NS2-3 protein in the cells of cattle persistently infected with non-cytopathogenic bovine viral diarrhea virus
- The Effects of a Vitamin D-deficient Diet on Chronic Cadmium Exposure in Rats
- ACUTE TOXICITY OF CADMIUM IN RATS WITH OR WITHOUT CADMIUM PRETREATMENT
- 302 EFFECTS OF CADMIUM CHLORIDB ON THE BLOOD AND URINARY EXAMINATIONS IN OVARIECTOMIZED RATS
- Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency
- NUTRITIONAL SECONDARY HYPERPARATHYROIDISM OCCURRING IN A STRAIN OF GERMAN SHEPHERD PUPPIES
- Possible Origin of CSF Antibodies Induced by Intrathecal Immunization and Prophylactic Effects against Intracerebral Rabies Virus Infection
- HUMAN FOCAL NODULAR HYPERPLASIA-LIKE LESION IN THE LIVER OF A CAT
- DISSEMINATED INTRAVASCULAR COAGULATION (DIC) IN RABBIT HAEMORRHAGIC DISEASE
- Clinical and Clinico-Pathologic Characteristics of Shiba Dogs with a Deficiency of Lysosomal Acid β-Galactosidase: A Canine Model of Human GM1 Gangliosidosis
- In vivo genotoxicity of 1-methylnaphthalene from comprehensive toxicity studies with B6C3F1 gpt delta mice
- Uterine Carcinosarcoma in a 2-year-old Female Wistar Hannover GALAS Rat
- Reporter gene mutation in the livers of gpt delta mice treated with 5-(hydroxymethyl)-2-furfural, a contaminant of various foods
- Prevalence of Fowl Glioma-Inducing Virus in Chickens of Zoological Gardens in Japan and Nucleotide Variation in the env Gene