Propagation of Swine Hemagglutinating Encephalomyelitis Virus and Pseudorabies Virus in Dorsal Root Ganglia Cells
スポンサーリンク
概要
- 論文の詳細を見る
Swine hemagglutinating encephalomyelitis virus (HEV) causes encephalomyelitis or vomiting and wasting disease in suckling piglets. Neurotoropism of the virus has been demonstrated in previous in vivo studies. In the present study, we investigated the infectivity and propagation of HEV in comparison with those of pseudorabies virus (PRV), another neurotropic virus, using dorsal root ganglia cells of newborn mice containing nerve cells and non-neuronal cells. HEV infected nerve cells but did not infect non-neuronal cells, whereas PRV infected both cell types. By using cytoskeletal inhibitors, it was suggested that propagation of HEV and PRV within and among nerve cells depended on microtubules and intermediate filaments of nerve cells, indicating that the viruses may be transported between the cell body and axonal terminals of neurons by fast axonal flow.
著者
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SAKODA Yoshihiro
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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Ochiai Kenji
Laboratory Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University
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Ochiai Kenji
Laboratory Of Comparative Pathology Department Of Veterimary Sciences Graduate School Of Veterimary
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SUNDEN Yuji
Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine
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UMEMURA Takashi
Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine
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Sakoda Yoshihiro
Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Umemura Takashi
Laboratory Of Comparative Pathology Department Of Veterinary Clinical Sciences Graduate School Of Ve
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HARA Yoko
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
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HASEBE Rie
Department of Prion Diseases, Graduate School of Veterinary Medicine, Hokkaido University
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HONDA Eiichi
Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Tokyo University of Agricu
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SUNDEN Yuji
Laboratory of Comparative Pathology, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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HONDA Eiichi
Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, Tokyo University of Agriculture and Technology
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