Effective Prevention against Rabies by Intracerebral Immunization in Mice
スポンサーリンク
概要
- 論文の詳細を見る
To evaluate the efficacy of intracerebral (IC) immunization, mice were immunized with a rabies vaccine by the subcutaneous (SC), intramuscular (IM) or IC route, and 10-fold the 50% lethal dose of rabies virus was inoculated into the hindleg of the immunized or non-immunized mice. The antibody titer in serum was elevated and boosted by additional immunization via all routes, but highest after the IC immunization followed by the IM and SC routes, in this order. Intracerebrally immunized mice were completely protected from death and the neurological signs of infection, whereas the IM or SC immunization only partly protected the mice. In mouse models, IC immunization is more effective at inducing a protective immune response against the transneural spread of rabies virus than IM or SC immunization.
著者
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KIDA Hiroshi
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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SAKODA Yoshihiro
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, H
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Ochiai Kenji
Laboratory Of Comparative Pathology Graduate School Of Veterinary Medicine Hokkaido University
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Ochiai Kenji
Laboratory Of Comparative Pathology Department Of Veterimary Sciences Graduate School Of Veterimary
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UMEMURA Takashi
Laboratory of Comparative Pathology, Hokkaido University School of Veterinary Medicine
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Sakoda Yoshihiro
Hokkaido Univ. Sapporo Jpn
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Sakoda Yoshihiro
Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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Umemura Takashi
Laboratory Of Comparative Pathology Department Of Veterinary Clinical Sciences Graduate School Of Ve
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SHIN Jae-Ho
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
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YANO Shiori
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
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Kida Hiroshi
Laboratory Of Microbiology Department Of Disease Control Hokkaido University Graduate School Of Vete
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Kida Hiroshi
Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk
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KIDA Hiroshi
Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University
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