Antigenic Variation Among Equine H 3 N 8 Influenza Virus Hemagglutinins

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概要

• 論文の詳細を見る

• To provide information on the antigenic variation of the hemagglutinins (HA) among equine H 3 influenza viruses, 26 strains isolated from horses in different areas in the world during the 1963-1996 period were analyzed using a panel of monoclonal antibodies recognizing at least 7 distinct epitopes on the H 3 HA molecule of the prototype strain A/equine/Miami/1/63 (H 3 N 8). The reactivity patterns of the virus strains with the panel indicate that antigenic drift of the HA has occurred with the year of isolation, but less extensively than that of human H 3 N 2 influenza virus isolates, and different antigenic variants co-circulate. To assess immunogenicity of the viruses, antisera from mice vaccinated with each of the 7 representative inactivated viruses were examined by neutralization and hemagglutination-inhibition tests. These results emphasize the importance of monitoring the antigenic drift in equine influenza virus strains and to introduce current isolates into vaccine. On the basis of the present results, equine influenza vaccine strain A/equine/Tokyo/2/71 (H 3 N 8) was replaced with A/equine/La Plata/1/93 (H 3 N 8) in 1996 in Japan. The present results of the antigenic analysis of the 26 strains supported the results of a phylogenetic analysis, that viruses belonging to each of the Eurasian and American equine influenza lineages have independently evolved. However, the current vaccine in Japan consists of two American H 3 N 8 strains ; A/equine/Kentucky/1/81 and A/equine/La Plata/1/93. It is also therefore recommended that a representative Eurasian strain should be included as a replacement of A/equine/Kentucky/1/81.

• 北海道大学の論文
• 2001-02-28

著者

• KIDA Hiroshi

  Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University

• OZAKI Hiroichi

  Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University

• Kida Hiroshi

  東京大 海洋研 大槌臨海研究セ

• Sugita Shigeo

  Division Of Molecular Biology Tochigi Laboratory Of Equine Research Institute Japan Racing Associati

• Kida Hiroshi

  Hokkaido Univ. Hokkaido Jpn

• Kida Hiroshi

  Department Of Cardiology Kanazawa National Hospital

• Kida Hiroshi

  Department Of Disease Control Graduate School Of Veterinary Medicine Hokkkaido University

• Imagawa Hiroshi

  Institute Of Applied Biochemistry University Of Tsukuba

• Imagawa Hiroshi

  Faculty Of Pharmaseutical Sciences Tokushima Bunri University

• Shimizu-nei Ayako

  Department Of Disease Control Hokkaido University Graduate School Of Veterinary Medicine

• Ozaki Hiroichi

  Department Of Disease Control Graduate School Of Veterinary Medicine Hokkaido University

• Ozaki Hiroichi

  Department Of Disease Control Hokkaido University Graduate School Of Veterinary Medicine

• Imagawa H

  Institute Of Applied Biochemistry University Of Tsukuba

• Sugiura T

  Equine Research Institute Tochigi Branch

• SUGIURA Takeo

  Division of Molecular Biology, Tochigi Laboratory of Equine Research Institute, Japan Racing Associa

• IMAGAWA Hiroshi

  Division of Molecular Biology, Tochigi Laboratory of Equine Research Institute, Japan Racing Associa

• Sugiura Takeo

  Equine Research Institute Tochigi Branch

• Kida Hiroshi

  Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk

• Kida Hiroshi

  Department Of Disease Control Graduate School Of Veterinary Medicine Hokkaido University

• Imagawa Hiroshi

  Faculty of Pharmaseutical Sciences, Tokushima Bunri University

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