Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks

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概要

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• The hemagglutinin (HA) of H3 human influenza viruses does not support viral replication in duck intestine despite its avian origin. A Leu-to-Gln mutation at position 226 and a Ser-to-Gly mutation at position 228 in the HA of human A/Udorn/307/72 (H3N2) permit a reassortant virus [human Udorn HA, with all other genes from A/mallard/New York/6750/78 (H2N2)] to replicate in ducks. To understand the molecular basis of this change in host range restriction, we investigated the receptor specificity of duck influenza viruses as well as of human-duck virus reassortants. The results indicate that the recognition of a glycoconjugate moiety possessing N-glycolneuramic acid (NeuGc) linked to galactose by the α2,3 linkage (NeuGcα2,3Gal) is associated with viral replication in duck intestine. Immunofluorescence assays with NeuGcα2,3Gal-specific antiserum detected this moiety primarily on the crypt epithelial cells of duck colon. Such recognition, together with biochemical evidence of NeuGc in crypt cells, correlated exactly with the ability of the virus to replicate in duck colon. These results suggest that recognition of the NeuGcα2,3-Gal moiety plays an important role in the enterotropism of avian influenza viruses.

• American Society for Microbiologyの論文

著者

• Kiso Makoto

  The Foundation For Ume Research Gakuen

• Suzuki Y

  School Of Pharmaceutical Sciences University Of Shizuoka

• Takada Ayato

  Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk

• KIDA Hiroshi

  Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University

• Okazaki Katsunori

  Department Of Disease Control Graduate School Of Veterinary Medicine Hokkaido University

• Okazaki Katsunori

  北海道大学 獣医研究 動物疾病制御

• Horimoto Taisuke

  Division Of Virology Department Of Microbiology And Immunology Institute Of Medical Science The Univ

• Kawaoka Y

  St. Jude Children's Res. Hospital Tennessee Usa

• Suzuki Y

  Fukuoka Inst. Technol. Fukuoka

• Otsuki K

  Tottori Univ. Tottori Jpn

• Suzuki T

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Kiso M

  The Foundation For Ume Research Gakuen

• Kida Hiroshi

  東京大 海洋研 大槌臨海研究セ

• 高田 礼人

  北海道大学人獣共通感染症リサーチセンター

• Ito Toshihiro

  Department Of Veterinary Public Health Faculty Of Agriculture Tottori University

• Suzuki Y

  Department Of Pharmacobiology And Therapeutics Faculty Of Pharmacy Meijo University

• Suzuki Y

  Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph

• Kida Hiroshi

  Hokkaido Univ. Hokkaido Jpn

• Kida Hiroshi

  Department Of Disease Control Graduate School Of Veterinary Medicine Hokkkaido University

• Kiso Makoto

  ニュージーランド

• Kiso Makoto

  Faculty Of Appleid Biological Science Gifu University

• Ishida H

  Hiroshima Univ. Hiroshima

• Ishida H

  Osaka Prefecture Univ. Osaka

• Ishida Hideharu

  Faculty Of Appleid Biological Science Gifu University

• Suganuma Taiyo

  (pressent Address)department Of Pharmacology Tokyo Women's Medical University

• Suzuki Takashi

  Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo

• Kitagawa Masayuki

  Department Of Applied Bioorganic Chemistry Gifu University

• ITO Toshihiro

  The Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University

• Ito Toshihiro

  The Avian Zoonosis Research Center Faculty Of Agriculture Tottori University

• Kida Hiroshi

  Laboratory Of Microbiology Department Of Disease Control Graduate School Of Veterinary Medicine Hokk

• Matsuoka Koji

  Department Of Functional Materials Science Saitama University

• Suzuki Y

  Department Of Pharmacology Faculty Of Pharmacy Meijo University

• Kida Hiroshi

  Department Of Disease Control Graduate School Of Veterinary Medicine Hokkaido University

• Kiso Makoto

  Department Of Applied And Bio-organic Chemistry Gifu University

• Ishida Hideharu

  Department Of Applied And Bio-organic Chemistry Gifu University

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