Adjuvant Effect of Grifolan on Antibody Production in Mice

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概要

• 論文の詳細を見る

• The effect of grifolan (GRN), a gel-forming (1→6)-branched (1→3)-β-D-glucan, on antibody produciton were examined. Sera from mice that were injected with GRN and trinitrophenyl ovalbumin (TNP-OVA) intraperitoneally showed a significantly increased level of anti-TNP IgG. However, injection of CRN and 10 μg of TNP-OVA alone showed a lowe antibody level. Two hundred fifty μg of TNP-OVA gave the maximum production of anti-TNP antibody. Enhanced antibody prduction was also observed in the culture supernatant of splenocyte obtained from GRN-administered mice. The culture supernatant contained a significant amount of nitric oxide (NO) in the case of GRN-administered mice. To observe the effect of NO on the antibody production induced by GRN, N-menomethyl arginine (NMMA), an inhibitor of NO synthetase, was added to the splenocyte cultures. The antibody level of supernatants containing NMMA was higher than that of control supernatants. These results suggest that GRN can enhance antibody production and that NO induced by stimulation with GRN concomitantlywith antibody production is a negative factor on the adjuvant activity. Inhibition of NO may increase the adjuvant effect of GRN.

• 社団法人日本薬学会の論文
• 1998-09-15

著者

• Suzuki Y

  School Of Pharmaceutical Sciences University Of Shizuoka

• OHNO Naohito

  Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha

• Ohno Naohito

  東京薬科大学 免疫学

• Ohno Naohito

  東京薬科大学 薬 微生物

• Ohno Naohito

  Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif

• Ohno N

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Adachi Yoshiyuki

  東京薬科大学 免疫学

• Adachi Y

  Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn

• Adachi Yoshiyuki

  Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• YADOMAE Toshiro

  Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha

• Suzuki Y

  Meijo Univ. Nagoya Jpn

• SUZUKI Yoko

  Laboratory of Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Phar

• Shingo Yuko

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Adachi Yoshiyuki

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Ohno Naohito

  Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma

• Ohno Naohito

  Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc

• Suzuki Y

  Core Research For Evolutional Science And Technology (crest Jst) University Of Shizuoka School Of Ph

• Suzuki Y

  Faculty Of Pharmacy Meijo University

• Yadomae T

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Ohno Naohito

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

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