Failure in Antitumor Activity by Overdose of an Immunomodulating β-Glucan Preparation, Sonifilan
スポンサーリンク
概要
- 論文の詳細を見る
Schizophyllan (SPG, Sonifilan) is a soluble (1→3)-β-D-glucan, used as a biological response modifier (BRM)with radiation therapy for cancer treatment in Japan. The mechanism of SPG mediated antitumor activity is thought to be via immune stimulation, which includes cytokine production, hematopoietic response, and so on. In this paper, we found that the activity of SPG was quite long-lived and an overdose significantly failed to display the antitumor activity. To demonstrate the mechanism several parameters were examined using a high dose of SPG administration as follow : i) the effect on vascular permeability in vivo, ii) the priming effect on tumor necrosis factor (TNF-α) production in vivo, iii) the effect on macrophage adherence to plastic plate in vivo, and iv) anti-Sarcoma 180 antibody production in vito. It was evident that vascular permeability and anti-Sarcoma 180 antibody production remained unchanged, but TNF-α production and adherence to a plastic plate was significantly reduced by a high dose of SPG. These facts strongly suggested that modulation of the cytokine syntheses and the leukocyte traffic would be the causative mechanisms of the failure of antitumor activity by an overdose of SPG.
- 社団法人日本薬学会の論文
- 2000-02-01
著者
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三浦 俊宏
鈴鹿医療科学大学
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ADACHI Yoshiyuki
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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OHNO Naohito
Laboratory far Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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Ohno Naohito
東京薬科大学 免疫学
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Ohno Naohito
東京薬科大学 薬 微生物
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Ohno Naohito
Lab. For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo Univ. Of Pharmacy And Lif
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Ohno N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Miura N
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Nagi Miura
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Adachi Yoshiyuki
東京薬科大学 免疫学
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Adachi Y
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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Adachi Yoshiyuki
Laboratory Far Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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MIURA Noriko
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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YADOMAE Toshiro
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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MIURA Toshihide
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pha
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SHIMADA Shigehiko
Kitasato University Hospital, Department of Pharmacy
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Adachi Yoshiyuki
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Ohno Naohito
Laboratory Of Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharma
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products Tokyo University Of Pharmacy And Life Scienc
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Miura T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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三浦 俊宏
Suzuka University of Medical Science and Technology
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Miura Noriko
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Miwa Takeshi
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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Yadomae T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Shimada Shigehiko
Kitasato University Hospital Department Of Pharmacy
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Miura Tsutomu
Research Sections Sanwa Shoyaku Co. Ltd.
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Ohno Naohito
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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