Corosolic Acid Induces GLUT4 Translocation in Genetically Type 2 Diabetic Mice(Pharmacognosy)
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概要
- 論文の詳細を見る
The effect of corosolic acid (CA) on blood glucose was studied in KK-Ay mice, an animal model of type 2 diabetes. CA (10mg/kg) reduced the blood glucose (p<0.05) of KK-Ay mice 4h after single oral administration when compared with the control group. However, CA did not change the plasma insulin. The muscle facilitative glucose transporter isoform 4 (GLUT4) translocation from low-density microsomal membrane to plasma membrane was significantly increased in the orally CA-treated mice when compared with that of the controls (p<0.05). These results suggest that the hypoglycemic effect of CA is derived, at least in part, from an increase in GLUT4 translocation in muscle. Therefore, it may be that CA has beneficial effects on hyperglycemia in type 2 diabetes.
- 公益社団法人日本薬学会の論文
- 2004-07-01
著者
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三浦 俊宏
鈴鹿医療科学大学
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ISHIDA Torao
Hi-tech Research Center, Suzuka University of Medical Science
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MIURA Toshihiro
Department of Internal Medicine, School of Medicine, Tokai University
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Seino Yutaka
Department of Cardiology, Kansai Electric Power Hospital
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Seino Y
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine:kansai El
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Ishida Torao
Hi-tech Res. Center Suzuka Univ. Of Medical Sci.
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Kaneko Tetsuo
Department Of Pharmaceutical Science Hiroshima International University
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ITOH Yasushi
Department of Clinical Nutrition, Suzuka University of Medical Science
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Miura T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Miwa T
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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三浦 俊宏
Suzuka University of Medical Science and Technology
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UEDA Naoya
Use Techno Corporation Co. Ltd.
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FUKUSHIMA Mitsuo
Department of Health Informatics Center Foundation for Biomedical Research and Innovation
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MATSUYAMA Futoshi
Use Techno Corporation Co. Ltd.
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KANEKO Tetsuo
Use Techno Corporation Co. Ltd.
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三浦 俊宏
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Kaneko T
Department Of Pharmaceutical Science Hiroshima International University
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Seino Y
Division Of Diabetes And Clinical Nutrition Kansai Electric Power Hospital
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Seino Yutaka
Department Of Cardiology Kansai Electric Power Hospital
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ITOH Yasushi
Suzuka University of Medical Science
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Seino Yutaka
Division Of Diabetes And Clinical Nutrition Kansai-denryoku Hospital
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Miura T
Department Of Internal Medicine School Of Medicine Tokai University
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Miura Toshihiro
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Itoh Yasushi
Department Of Clinical Nutrition
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Miura Tsutomu
Research Sections Sanwa Shoyaku Co. Ltd.
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