Antidiabetic Activity of Lyophyllum decastes in Genetically Type 2 Diabetic Mice
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概要
- 論文の詳細を見る
The antidiabetic activity of Lyophyllum decastes (Tricholomataceac) was investigated in KK-Ay mice, an animal model of genetically type 2 diabetes with hyperinsulinemia. The water extract of Lyophyllum decastes (LD) (500 mg/kg body weight) reduced the blood glucose of KK-Ay mice 7 h after a single oral administration (p<0.05) when compared with control. LD reduced the blood glucose of KK-Ay mice 3 weeks after repeated administration (p<0.05), and also significantly lowered the serum insulin of KK-Ay mice under similar conditions (p<0.01). However; LD did not affect the blood glucose in normal mice. LD tended to decrease of the blood glucose in an insulin tolerance test. In addition, the muscle content of facilitative glucose transporter isoform 4 (GLUT4) protein content in the plasma membrane fraction from muscle significantly increased in the orally LD-treated KK-Ay mice when compared to that of the controls (p<0.01). These results suggest that the antidiabetic activity of LD is derived, at least in part, from a decrease in insulin resistance, due to the increase of GLUT4 protein content in the plasma membrane of the muscle.
- 社団法人日本薬学会の論文
- 2002-09-01
著者
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Iwamoto Naoki
鈴鹿医療科学大学
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Iwamoto Naoki
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Iwamoto Naoki
Department Of Clinical Informative Medicine Gifu University Graduate School Of Medicine
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Kato M
Department Of Clinical Nutrition Suzuka University Of Medical Science
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三浦 俊宏
鈴鹿医療科学大学
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SUZUKI Ikukatsu
Department of Clinical Nutrition
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MIURA Toshihiro
Department of Internal Medicine, School of Medicine, Tokai University
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Kato Masaya
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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加藤 眞行
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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KATO Motoshi
Department of Clinical Nutrition, Suzuka University of Medical Science
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加藤 昌子
Div. Of Chemistry Fac. And Graduate School Of Sci. Hokkaido Univ.
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Park Sang
Graduate School Of Biotechnology Korea University
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ITOH Yasushi
Department of Clinical Nutrition, Suzuka University of Medical Science
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KUBO Mizue
Department of Clinical Nutrition, Suzuka University of Medical Science
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UKAWA Yuuichi
Research Center Eishogen Co., Ltd.
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KITA Yukio
Research Center Eishogen Co., Ltd.
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加藤 昌子
奈良女大院人間文化
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Miura T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Miwa T
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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三浦 俊宏
Suzuka University of Medical Science and Technology
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三浦 俊宏
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Kato M
Department Of Pharmacotherapeutics Showa Pharmaceutical University
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Kako M
Suzuka Univ. Medical Sci. And Technol. Mie Jpn
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Kita Yukio
Research Center Eishogen Co. Ltd.
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Park Sang
Graduate School Of Medical Imaging Suzuka University Of Medical Science
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Ukawa Yuuichi
Research Center Eishogen Co. Ltd.
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ITOH Yasushi
Suzuka University of Medical Science
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Suzuki Ikukatsu
Department Of Clinical Nutrition Faculty Of Health And Hygiene; Suzuka University Of Medical Science
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Miura T
Department Of Internal Medicine School Of Medicine Tokai University
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Miura Toshihiro
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Itoh Yasushi
Department Of Clinical Nutrition
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Miura Tsutomu
Research Sections Sanwa Shoyaku Co. Ltd.
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Iwamoto Naoki
Department Of Applied Biological Chemistry Graduate School Of Agriculture Kinki University
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