Docosahexanoic Acid (DHA) Improved Glucose and Lipid Metabolism in KK-A^y Mice with Genetic Non-Insulin-Dependent Diabetes Mellitus

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The hypoglycemic and hypolipidemic effect of docosahexaenoic acid (DHA; C22 : 6ω-3) ethyl ester was examined in KK-A^y mice and neonatal streptozotocin-induced diabetic (NSZ) which are respectively obese and lean animal models of non-insulin-dependent diabetes mellitus (NIDDM), and in ddY normal mice. Single administration of DNA (500 mg/kg body weight) to KK-A^y mice significantly reduced (p<0.05) the blood glucose levels (BG) (p<0.05) and plasma free fatty acid levels (FFA) (p<0.05) at 10 h after oral administration when compared with control group. DHA (500 mg/kg body weight)-treated NSZ and normal mice, however, showed no change in these parameters. In addition, repeated administration of DHA (100 mg/kg) to KK-A^y mice significantly suppressed the increment of BG (p<0.05) and plasma triglyceride levels (TG) (p<0.01), and significantly decreased FFA (p<0.05) at 30 d compared with control group. DHA also significantly decreased the blood glucose at 60 and these 120 min on insulin tolerance test (ITT). From findings, it seems likely that DHA exhibits its hypoglycemic effects by increasing insulin sensitivity. It is concluded that DHA would be useful for treatment of obese type NIDDM with insulin resistance.
公益社団法人日本薬学会の論文
1997-05-15