Effect of Tangzhiqing on Glucose and Lipid Metabolism in Genetically Type 2 Diabetes KK-Ay Mice
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概要
- 論文の詳細を見る
The hypoglycemic and hypolipidemic effects of Tangzhiqing (abbreviated TZ) a mixture of Mulberry Leaf, Lotus Leaf, Danshen Root, and Hawthorn Leaf, were investigated in KK-Ay mice, an animal model of type 2 diabetes. TZ reduced blood glucose, total cholesterol, and triglyceride levels of KK-Ay mice at 4 weeks after oral administration. TZ also improved sucrose or maltose tolerance. Maltase activity in small intestine significantly decreased in the TZ-treated KK-Ay mice. These results support the hypothesis that TZ improves glucose metabolism by reducing α-glycosidase activity. Therefore TZ might have beneficial effects on hyperglycemia and hyperlipidemia in type 2 diabetes.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
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三浦 俊宏
鈴鹿医療科学大学
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ZHANG Wen-ping
Faculty of Acupuncture and Moxibustion, Suzuka University of Medical Science
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ISHIDA Torao
Hi-tech Research Center, Suzuka University of Medical Science
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MIURA Toshihiro
Department of Internal Medicine, School of Medicine, Tokai University
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Ishida Torao
Hi-tech Res. Center Suzuka Univ. Of Medical Sci.
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Zhang Wen-ping
Faculty Of Acupuncture And Moxibustion Suzuka University Of Medical Science
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Ma Dong-ming
Tianjin University Of Traditional Chinese Medicine
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Zhao Qi-duo
Tianjin University Of Traditional Chinese Medicine
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三浦 俊宏
Suzuka University of Medical Science and Technology
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ISHIHARA Eriko
Department of Clinical Nutrition, Suzuka University of Medical Science
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Zhang De
Tianjin University Of Traditional Chinese Medicine
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Zhang Bo
Tianjin University Of Traditional Chinese Medicine
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Ishihara Eriko
Dep. Of Clinical Nutrition Suzuka Univ. Of Medical Sci.
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Ishihara Eriko
Department Of Biology Faculty Of Education Gifu University
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Wang Wei
Tianjin University of Traditional Chinese Medicine
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Shi Hong
Tianjin University of Traditional Chinese Medicine
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Masayuki Masayuki
Faculty of Acupuncture and Moxibustion, Suzuka University of Medical Science
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Gao Xiu
Tianjin University of Traditional Chinese Medicine
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Miura Toshihiro
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Miura Tsutomu
Research Sections Sanwa Shoyaku Co. Ltd.
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