Antidiabetic Effect of Nitobegiku, the Herb Tithonia diversifolia, in KK-Ay Diabetic Mice(Pharmacognosy)
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概要
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Nitobegiku (the herb of Tithonia diversifolia (HEMSL) A. GRAY) has been used as a medicinal plant for diabetes. The antidiabetic effect of an 80% ethanol extract of Nitobegiku (Td) was investigated in KK-Ay-mice, an animal model of type 2 diabetes. Td (500mg/kg body weight) reduced the blood glucose of KK-Ay mice 7h after a single oral dose. No change in blood glucose in Td-treated normal mice (ddY) was seen. Td (500mg/kg) reduced blood glucose in KK-Ay mice 3 weeks after a single oral dose and also significantly lowered plasma insulin in KK-Ay mice under similar conditions. Td-treated KK-Ay mouse blood glucose was significantly decreased in an insulin tolerance test. These results support the hypothesis that Td improves glucose metabolism by reducing insulin resistance. Therefore, Nitobegiku may be useful for the treatment of type 2 diabetes.
- 公益社団法人日本薬学会の論文
- 2005-11-01
著者
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ISHIDA Torao
Hi-tech Research Center, Suzuka University of Medical Science
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MIURA Toshihiro
Department of Internal Medicine, School of Medicine, Tokai University
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Ishida Torao
Hi-tech Res. Center Suzuka Univ. Of Medical Sci.
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NOSAKA Kosuke
Hiro International Co., Ltd.
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ISHII Hiroyasu
Hiro International Co., Ltd.
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Nosaka Kosuke
Hiro International Co. Ltd.
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Ishii Hiroyasu
Hiro International Co. Ltd.
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Miura Toshihiro
Department Of Clinical Nutrition Suzuka University Of Medical Science
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