Effect of Alpha-Linolenic Acid on Blood Glucose, Insulin and GLUT4 Protein Content of Type 2 Diabetic Mice
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概要
- 論文の詳細を見る
Alpha-linolenic acid (LL) was tested for antidiabetic activity in KK-Ay mice, an animal model of type 2 diabetes. Repeated administration of LL (300mg/kg) to KK-Ay mice significantly suppressed the increment of blood glucose at 21d (p<0.05). However, no affect on the blood glucose level in normal mice was seen, indicating that LL is useful in treating type 2 diabetes. In addition, LL improved hyperinsulinemia in KK-Ay mice (p<0.01). LL also significantly decreased the blood glucose at 120min in the insulin tolerance test (p<0.05). The muscle content of facilitative glucose transpoter isoform 4 (GLUT4) protein content in the total membrane fraction from KK-Ay mouse muscle significantly increased in the LL-treated mice when compared to that in the controls (p<0.01). From these findings, it seems likely that the hypoglycemic effect of LL is derived, at least in part, from the decrease in insulin resistance, due presumably to the increase of GLUT4 protein content in total membrane of the muscle.
- 社団法人日本薬学会の論文
- 2000-12-01
著者
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Iwamoto Naoki
鈴鹿医療科学大学
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Iwamoto Naoki
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Iwamoto Naoki
Department Of Clinical Informative Medicine Gifu University Graduate School Of Medicine
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Kato M
Department Of Clinical Nutrition Suzuka University Of Medical Science
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三浦 俊宏
鈴鹿医療科学大学
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ISHIDA Torao
Hi-tech Research Center, Suzuka University of Medical Science
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MIURA Toshihiro
Department of Internal Medicine, School of Medicine, Tokai University
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Tanigawa Keiichiro
Department Of Clinical Nutrition Suzuka University Medical Science
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Tanigawa Keiichiro
鈴鹿医療科学大学 医療栄養
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Tanigawa Keiichiro
Department Of Clinical Nutrition Suzuka University Of Medical Science And Technology
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Tanigawa Keiichiro
Department Of Clinical Nutrition Suzuka University Of Medical Science Faculty Of Healty Of Science
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Tanigawa K
Taiho Pharmaceutical Co. Ltd. Saitama Jpn
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Tanigawa Keiichiro
Department Of Clinical Nutrition Faculty Of Health Science Suzuka University Of Medical Science
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Kato Masaya
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
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Ishida Torao
Hi-tech Res. Center Suzuka Univ. Of Medical Sci.
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加藤 眞行
New Drug Research Laboratories Fujisawa Pharmaceutical Co. Ltd.
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KATO Motoshi
Department of Clinical Nutrition, Suzuka University of Medical Science
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加藤 昌子
Div. Of Chemistry Fac. And Graduate School Of Sci. Hokkaido Univ.
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Nakao Masami
Department of Clinical Nutrition, Suzuka University of Medical Science
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加藤 昌子
奈良女大院人間文化
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Nakao Masami
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Miura T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Miwa T
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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三浦 俊宏
Suzuka University of Medical Science and Technology
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三浦 俊宏
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Kato M
Department Of Pharmacotherapeutics Showa Pharmaceutical University
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Kako M
Suzuka Univ. Medical Sci. And Technol. Mie Jpn
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Miura T
Department Of Internal Medicine School Of Medicine Tokai University
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Miura Toshihiro
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Miura Tsutomu
Research Sections Sanwa Shoyaku Co. Ltd.
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Iwamoto Naoki
Department Of Applied Biological Chemistry Graduate School Of Agriculture Kinki University
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