Effect of Momordica charantia on Adenosine Monophosphate-activated Protein Kinase in Genetically Type 2 Diabetic Mice Muscle
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概要
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The hypoglycemic activity of Momordica charantia L. (Cucurbitaceae) (MC) was investigated in KK-Ay mice, an animal model of type 2 diabetes. The water extract of the fruit of MC (100 mg/kg) reduced the blood glucose of KK-Ay mice 2 and 4 hr after oral administration (p<0.05). In addition, the muscle adenosine monophosphate-activated protein kinase (AMPK) was significantly activated in the orally MC-treated mice when compared to that of the controls (p<0.01). These results suggest that the antidiabetic effect of MC is derived, at least in part, from an activation of AMPK in the muscle.
- 公益社団法人 日本薬学会の論文
著者
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ISHIDA Torao
Hi-tech Research Center, Suzuka University of Medical Science
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MIURA Toshihiro
Department of Internal Medicine, School of Medicine, Tokai University
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Ishida Torao
Hi-tech Res. Center Suzuka Univ. Of Medical Sci.
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ISHIHARA Eriko
Department of Clinical Nutrition, Suzuka University of Medical Science
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Takagi Satoshi
鈴鹿医療科学大学医療栄養学科
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Ishihara Eriko
Department Of Biology Faculty Of Education Gifu University
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Kawata Takanori
Department of Clinical Nutrition, Suzuka University of Medical Science
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Takagi Satoshi
Graduate School of Health Science, Suzuka University of Medical Science
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Nanpei Mai
Department of Clinical Nutrition, Suzuka University of Medical Science
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Nakao Haruka
Department of Clinical Nutrition, Suzuka University of Medical Science
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Miura Toshihiro
Department Of Clinical Nutrition Suzuka University Of Medical Science
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