Antidiabetic Mechanism of Bakumondo-inshi
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概要
- 論文の詳細を見る
To determine the antidiabetic mechanism of Bakumondo-inshi (BI), we examined its effects on glucose absorption, α-glucosidase activity, sodium-dependent glucose transporter and facilitative glucose transporter isoform 5 (GLUT5) in small intestine. The oral administration of BI into KK-Ay mice caused a significant decrease in the glucose absorption in small intestine. The small intestine content of active glucose transporter isoform (SGLUT) protein content from KK-Ay mouse significantly decreased in the BI-treated KK-Ay mice compared to that in the controls. However, the small intestine content of facilitative glucose transporter isoform, GLUT5 protein content did not change. The α-glucosidase activity in small intestine significantly decreased in the BI-treated KK-Ay mice. These results suggest that the antidiabetic effect of BI is derived, at least in part, from a decrease of glucose absorption in small intestine, due to the reduction of SGLUT protein content in total membrane of the small intestine and the reduction of α-glucosidase activity. Because of its therapeutic mechanism BI could be a new category of therapeutic agent for non-insulin dependent diabetic mellitus.
- 公益社団法人日本薬学会の論文
- 1999-04-15
著者
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Kato M
Department Of Clinical Nutrition Suzuka University Of Medical Science
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三浦 俊宏
鈴鹿医療科学大学
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MIURA Toshihiro
Department of Internal Medicine, School of Medicine, Tokai University
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Tanigawa Keiichiro
Department Of Clinical Nutrition Suzuka University Medical Science
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Tanigawa Keiichiro
鈴鹿医療科学大学 医療栄養
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Tanigawa Keiichiro
Department Of Clinical Nutrition Suzuka University Of Medical Science And Technology
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Seino Yutaka
Department of Cardiology, Kansai Electric Power Hospital
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Tanigawa Keiichiro
Department Of Clinical Nutrition Suzuka University Of Medical Science Faculty Of Healty Of Science
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Seino Y
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine:kansai El
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Tanigawa K
Taiho Pharmaceutical Co. Ltd. Saitama Jpn
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Tanigawa Keiichiro
Department Of Clinical Nutrition Faculty Of Health Science Suzuka University Of Medical Science
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ISHIHARA Eriko
鈴鹿医療科学大学
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加藤 昌子
Div. Of Chemistry Fac. And Graduate School Of Sci. Hokkaido Univ.
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Miura T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Miwa T
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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三浦 俊宏
Suzuka University of Medical Science and Technology
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KAKO Mami
Department of Clinical Nutrition, Suzuka University of Medical Science
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ISHIHARA Eriko
Department of Clinical Nutrition, Suzuka University of Medical Science
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三浦 俊宏
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Kato M
Department Of Pharmacotherapeutics Showa Pharmaceutical University
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Kako M
Suzuka Univ. Medical Sci. And Technol. Mie Jpn
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Seino Y
Division Of Diabetes And Clinical Nutrition Kansai Electric Power Hospital
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Seino Yutaka
Department Of Cardiology Kansai Electric Power Hospital
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Ishihara Eriko
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Ishihara Eriko
Department Of Biology Faculty Of Education Gifu University
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Seino Yutaka
Division Of Diabetes And Clinical Nutrition Kansai-denryoku Hospital
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Miura T
Department Of Internal Medicine School Of Medicine Tokai University
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Miura Toshihiro
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Miura Tsutomu
Research Sections Sanwa Shoyaku Co. Ltd.
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