POSSIBLE ROLE OF PROSTAGLANDINS IN THE REGULATION OF INSULIN RELEASE FROM RAT PANCREATIC ISLETS
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概要
- 論文の詳細を見る
To clarify whether prostaglandin synthesis is involved in the regulation of insulin release from isolated rat islets, we performed three different experiments. The direct effects of prostaglandin E_1 and prostacyclin on insulin release were investigated. Neither prostaglandin had any effect in the presence of low and high concentrations of glucose. Indomethacin, aspirin^<[○!R]> (acetylsalicylic acid) and flurbiprofen, inhibitors of cyclooxygenase, did not have a significant effect on insulin release evoked by glucose. Exogenous phospholipase A_2 purified from bee venom and melittin stimulated insulin release. A potent and selective inhibitor of phospholipase A_2,mepacrine, inhibited glucose-induced insulin release. The present work indicates that 1) cyclooxygenase does not participate early release of insulin from islet 2) activation of phospholipase A_2 might be involved in insulin stimulus-secretion coupling.
- 島根大学の論文
著者
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Tanigawa Keiichiro
Department Of Internal Medicine Shimane Medical University
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Tanigawa Keiichiro
Department Of Clinical Nutrition Suzuka University Of Medical Science And Technology
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Tanigawa K
Shimane Medical Univ. Izumo Jpn
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Tanigawa Keiichiro
Department Of Clinical Nutrition Suzuka University Of Medical Science Faculty Of Healty Of Science
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Tanigawa Keiichiro
Department Of Clinical Nutrition Faculty Of Health Science Suzuka University Of Medical Science
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Note Shinya
Department of Internal Medicine-I, Shimane Medical University
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OHGUNI SATOSHI
The First Division, Department of Medicine, Shimane Medical University
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OHGUNI Satoshi
Department of Internal Medicine, Shimane Medical University
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MASAKI Yohji
Department of Internal Medicine, Shimane Medical University
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TSUCHIYAMA Shinichi
Department of Internal Medicine, Shimane Medical University
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MASAKI Yohzi
Department of Internal Medicine, Shimane Medical University
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Note Shinya
Department Of Internal Medicine Shimane Medical University
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Masaki Yohji
Department Of Internal Medicine Shimane Medical University
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Ohguni S
Heisei Memorial Hospital Shimane Jpn
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Tsuchiyama Shinichi
Department Of Internal Medicine Shimane Medical University
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Note S
Department Of Internal Medicine Shimane Medical University
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Ohguni Satoshi
Department Of Internal Medicine Matsue Municipal Hospital
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