THE EFFECT OF A HYPOGLYCEMIC SULFONYLUREA ON INSULIN RELEASE FROM ISOLATED RAT PANCREATIC ISLETS
スポンサーリンク
概要
- 論文の詳細を見る
The effects of hypoglycemic sulfonylurea gliclazide on insulin release and its interaction with tumor-promoting phorbol ester in rat pancreatic islets were examined. Lower concentrations of gliclazide stimulated insulin release in the presence of 5.6mM glucose, but the addition of high concentrations of gliclazide resulted in a tendency to reduce insulin release. The stimulatory action of gliclazide on insulin release was abolished in the absence of Ca^<2+>. Gliclazide also failed to stimulate insulin release in the presence of 16.7mM glucose, and 50μM gliclazide inhibited insulin release significantly. A synergistic effect of gliclazide on insulin release was observed in the presence of phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Such a combined effect of gliclazide with TPA was inhibited when extracellular Ca^<2+> was not present. These results indicate that gliclazide stimulates insulin release to affect Ca^<2+> handling in the pancreatic B cell.
- 島根大学の論文
著者
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Tanigawa Keiichiro
Department Of Internal Medicine Shimane Medical University
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Tanigawa Keiichiro
Department Of Clinical Nutrition Suzuka University Of Medical Science And Technology
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Tanigawa K
Shimane Medical Univ. Izumo Jpn
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Tanigawa Keiichiro
Department Of Clinical Nutrition Suzuka University Of Medical Science Faculty Of Healty Of Science
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Tanigawa Keiichiro
Department Of Clinical Nutrition Faculty Of Health Science Suzuka University Of Medical Science
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Note Shinya
Department of Internal Medicine-I, Shimane Medical University
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OHGUNI SATOSHI
The First Division, Department of Medicine, Shimane Medical University
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OHGUNI Satoshi
Department of Internal Medicine, Shimane Medical University
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MASAKI Yohji
Department of Internal Medicine, Shimane Medical University
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TSUCHIYAMA Shinichi
Department of Internal Medicine, Shimane Medical University
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Note Shinya
Department Of Internal Medicine Shimane Medical University
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Masaki Yohji
Department Of Internal Medicine Shimane Medical University
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Ohguni S
Heisei Memorial Hospital Shimane Jpn
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Tsuchiyama Shinichi
Department Of Internal Medicine Shimane Medical University
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Note S
Department Of Internal Medicine Shimane Medical University
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Ohguni Satoshi
Department Of Internal Medicine Matsue Municipal Hospital
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