Correlation of Plasma Free Thyroxine Levels with Insulin Sensitivity and Metabolic Clearance Rate of Insulin in Patients with Hyperthyroid Graves' Disease
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概要
- 論文の詳細を見る
Insulin sensitivity, metabolic clearance rate of insulin (MCR-I) and basal posthepatic insulin delivery rate (BIDR) were investigated by means of euglycemic clamp technique in 8 normal subjects and 8 patients with hyperthyroid Graves disease. The mean (±SD) steady-state glucose infusion rate (SSGIR) was lower in hyperthyroid Graves patients than in normal subjects (228.9±57.0 vs. 290.9±49.4 mg/m2/min, p<0.05). Both MCR-I and BIDR were higher in hyperthyroid Graves patients than in normal subjects (1162.9±517.1 vs. 463.5±103.9 ml/m2/min, p<0.005; 17.7±12.6 vs. 3.6±0.9 mU/m2/min, p<0.01, respectively). Plasma free T4 levels showed a close correlation with MCR-I (r=0.77, p<0.05) and BIDR (r=0.81, p<0.05), respectively, in Graves patients. These findings indicate that hyperthyroidism is characterized by not only a decrease in insulin sensitivity, but also an increase in basal insulin secretion and the metabolic clearance rate of insulin, which are correlated with plasma free T4 levels.(Internal Medicine 34: 339-341, 1995)
- 社団法人 日本内科学会の論文
著者
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Kato Y
Department Of Endocrinology Metabolism And Hematological Oncology School Of Medicine Shimane Univers
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Kato Yuzuru
島根大学 医学部内分泌代謝･血液腫瘍内科
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Kato Yuzuru
The First Division Department Of Medicine Shimane Medical University
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OHGUNI SATOSHI
The First Division, Department of Medicine, Shimane Medical University
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Notsu Kazumi
The First Division Department Of Medicine Shimane Medical University
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Ohguni S
Heisei Memorial Hospital Shimane Jpn
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Kato Yuzuru
First Division Department Of Medicine Shiman Medical University
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NOTSU KAZUMI
The First Department of Internal Medicine, Shimane Medical University
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