Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Corosolic acid (CRA), a constituent of Banaba leaves, has been reported to exert anti-hypertension, anti-hyperinsulinemia, anti-hyperglycemia, and anti-hyperlipidemia effects as well as to induce anti-inflammatory and anti-oxidative activities. The aim of this study was to investigate the inhibitory effects of CRA on the development of obesity and hepatic steatosis in KK-Ay mice, a genetically obese mouse model. Six-week-old KK-Ay mice were fed a high fat diet for 9 weeks with or without 0.023% CRA. Nine-week CRA treatment resulted in 10% lower body weight and 15% lower total fat (visceral plus subcutaneous fat) mass than in control mice. CRA treatment reduced fasting plasma levels of glucose, insulin, and triglyceride by 23%, 41%, and 22%, respectively. The improved insulin sensitivity in CRA-treated mice may be due on part to the increased plasma adiponectin and white adipose tissue (WAT) AdipoR1 levels. In addition, CRA treatment increased the expression of peroxisome proliferator-activated receptor (PPAR)α in liver and PPARγ in WAT. This is the first study to show that CRA treatment can contribute to reduced body weight and amelioration of hepatic steatosis in mice fed a high fat diet, due in part to increased expression of PPARα in liver and PPARγ in WAT.
- 公益社団法人日本薬学会の論文
- 2008-04-01
著者
-
Yamada Koutaro
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine
-
Yamada Kotaro
Department Of Engineering Hiroshima University
-
三浦 俊宏
鈴鹿医療科学大学
-
MIURA Toshihiro
Department of Internal Medicine, School of Medicine, Tokai University
-
Seino Yutaka
Department of Cardiology, Kansai Electric Power Hospital
-
Seino Y
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine:kansai El
-
KUNITOMO Masaru
Department of Pharmacology, School of Pharmaceutical Sciences, Mukogawa Women's University
-
Kaneko Tetsuo
Department Of Pharmaceutical Science Hiroshima International University
-
INAGAKI Nobuya
Department of Diabetes & Clinical Nutrition, Graduate School of Medicine, Kyoto University
-
TSUDA Kinsuke
Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University
-
Miura T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
-
Miwa T
The 6th Department Of Internal Medicine School Of Medicine Tokai University
-
三浦 俊宏
Suzuka University of Medical Science and Technology
-
Fujiwara Hideya
Department of Cardiovascular Medicine, Osaka Nakatsu Saiseikai Hospital
-
HOSOKAWA Masaya
Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine
-
YAMADA Chizumi
Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine
-
WATANABE Rie
Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine
-
FUJIMOTO Shimpei
Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine
-
Kunitomo Masaru
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
Kano-ishihara Tomomi
Discovery Research Laboratory Tanabe Seiyaku Co. Ltd.
-
三浦 俊宏
Department Of Clinical Nutrition Suzuka University Of Medical Science
-
Kaneko T
Department Of Pharmaceutical Science Hiroshima International University
-
Watanabe Rie
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine
-
Seino Y
Division Of Diabetes And Clinical Nutrition Kansai Electric Power Hospital
-
Seino Yutaka
Department Of Cardiology Kansai Electric Power Hospital
-
Yamada Chizumi
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine
-
Inagaki Nobuya
Department Of Diabetes & Clinical Nutrition Graduate School Of Medicine Kyoto University
-
Fujiwara Hideya
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine
-
Fujiwara Hideya
Department Of Cardiovascular Medicine Osaka Nakatsu Saiseikai Hospital
-
Tsuda Kinsuke
Laboratory Of Metabolism Graduate School Of Human And Environmental Studies Kyoto University
-
Tsuda Kinsuke
Graduate School Of Human Science Kyoto University
-
Tsuda Kinsuke
Kyoto Univ. Kyoto Jpn
-
Hosokawa Masaya
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine
-
Seino Yutaka
Division Of Diabetes And Clinical Nutrition Kansai-denryoku Hospital
-
Miura T
Department Of Internal Medicine School Of Medicine Tokai University
-
Miura Toshihiro
Department Of Clinical Nutrition Suzuka University Of Medical Science
-
Miura Tsutomu
Research Sections Sanwa Shoyaku Co. Ltd.
-
Fujimoto Shimpei
Division Of Diabetes And Clinical Nutrition Kansai Electric Power Hospital
-
Fujimoto Shimpei
Department Of Diabetes And Clinical Nutrition Graduate School Of Medicine Kyoto University
-
KUNITOMO Masaru
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University
-
YAMADA Chizumi
Department of Clinical Health Science, Tokai University School of Medicine
関連論文
- T-Square Term of Electrical Resistivity : Condensed Matter and Statistical Physics
- 28aPS-117 スピネルフラストレート系MCr_2O_4の中性子非弾性散乱(28aPS 領域3ポスターセッション(スピントロニクス・フラストレーション系・実験技術),領域3(磁性,磁気共鳴))
- 27p-PS-52 La_Sr_xCu_Zn_yO_4の中性子非弾性散乱
- 30p-APS-27 La_Sr_xCu_Zn_yO_4の磁性
- X-ray and Electron Diffraction Study of a Precipitation Phase in Nd_Ce_CuO_ Single Crystal(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- 5p-G-1 酸化物超伝導体のスピン揺動 : 中性子散乱
- 30a-PS-14 MnPのブルリアン錯乱II
- 30a-PS-13 MnPのブリルアン錯乱I
- 25a-PS-62 界面の乱れたCo/Cu人工格子の中性子反射
- 30p-PSA-25 有機反強磁性体TPVの中性子回折
- 13p-PSA-6 有機磁性体TPVの単結晶の磁性
- 19aXD-8 高温超伝導母物質の共鳴非弾性X線散乱 : モットギャップの運動量依存性(高温(中性子μSR X線),領域8(強相関系 : 高温超伝導,強相関f電子系など))
- 25aWA-10 Nd_Ce_CuO_4における電荷励起の波数依存性 : 共鳴非弾性X線散乱による研究(高温超伝導(磁気励起,1/8問題),領域8(強相関系:高温超伝導,強相関f電子系など))
- 5p-H-1 Bi_2CuO_4の結晶構造と磁性
- 29p-ZE-7 Bi_2Cuo_4のサブミリ波ESR III
- 28p-ZC-12 Bi_2CuO_4のサブミリ波ESR II
- 25a-F-3 Bi_2CuO_4のサブミリ波ESR
- 6p-Z-1 La_<:2-x>l:Sr_xCuO_<:4-y>l:の磁性と伝導における熱処理効果
- 3a-F-15 Nd_2CuO_4とLa_2CuO_4系の磁気的性質と2次元スピン揺動
- 3a-F-14 Nd_2CuO_4の磁気的逐次相転移と2次元スピン揺動
- 5p-H-3 Nd_2CuO_4及びPr_2CuO_4の磁性
- 27p-PS-6 La_eCuO_の粉末中性子構造解析
- 27p-PS-9 La_2CuO_単結晶の磁性と酸素欠陥
- Dynamical Magnetic Structure of the Spin Density Wave State in Cr
- Magnetic Excitations in Spin Density Wave (SDW) State of Cr
- First Evidence of Interfacial Magnetic Roughness in Fe/Cr Artificial Multilayer Studied by Neutron Diffraction Measurement
- Magnetic Phase Diagram and Metal-Insulator Transition of NiS_Se_x : Condensed Matter: Electronic Properties, etc.
- Dynamical Susceptibility in Ferromagnetic Metal of CoS_2 : Inelastic Magnetic Neutron Scattering
- 24aWL-1 無限枚層鉄酸化物SrFeO_2の粉末中性子非弾性散乱による磁気励起の研究(24aWL 量子スピン(二次元系),領域3(磁性,磁気共鳴))
- Theory of Superconductivity in CeMIn_5 (M=Co, Rh, Ir) on the Basis of the Three Dimensional Periodic Anderson Model(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Calculation of Penetration Depth and T_c in κ-(ET)_2Cu(NCS)_2 under Pressure(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Theory of Superconductivity in PuCoGa_5 (Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Possible Pairing Symmetry of Superconductor Na_xCoO_2・yH_2O (Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Neutron Scattering Studies on Structural Phase Transition in CeCu_6 and LaCu_6
- 28pYL-8 中性子散乱によるオーバードープLa_Sr_xCu_Zn_yO_4 (x〜0.21,y〜0.01)の静的磁気相関の研究
- 23pSG-1 La_Sr_xCu_Zn_yO_4単結晶のx=0.21における異常の中性子散乱による研究
- Analysis of Superconductivity Induced by On-site Coulomb Repulsion on Three-dimensional Cubic Lattice : Based on Third Order Perturbation Theory
- Analysis of Superconductivity Induced by On-site Coulomb Repulsion on Three-dimensional Cubic Lattice : Based on Third Order Perturbation Theory
- Study of Superconductivity in Borocarbides on the Basis of Perturbation Theory
- Dynamic Spin Properties of La_Sr_CuO_4
- Low-Energy Spin Fluctuations in La_Sr_xCU_Zn_yO_4 (x=0.14, y=0.012)
- Spin Correlations in High Temperature Superconductors of "214" Cuprate Oxides : II-C Neutron Scattering, NMR and NQR and Ultrasonics : II Oxide Superconductors; Experiments II : Electronic States
- An Overall Energy Spectrum of Magnetic Fluctuations in the Superconducting La_Sr_CuO_4
- 29a-Q-1 La_2NiO_のラマン、赤外分光
- 29a-W-5 Bi_2CuO_4の強磁場ESR
- 29p-PSB-26 CaCuO_3のラマン散乱
- 28aA11 光集中FZ炉の照射分布と(La,Sr)_2CuO_4の単結晶育成(融液成長II)
- (Nd,Pr)_Ce_xCuO_4における反強磁性スピン相関
- 5a-PS-37 (La_Sr_x)_2CuO_4におけるスピン相関のSrドーピング効果
- Field-Induced Uniform Antiferromagnetic Order Associated with Superconductivity in Pr_LaCe_xCuO_(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Dietary Corosolic Acid Ameliorates Obesity and Hepatic Steatosis in KK-Ay Mice(Pharmacognosy)
- Antidiabetic Effects of Corosolic Acid in KK-Ay Diabetic Mice(Pharmacognosy)
- 30p-WC-11 Pr_Ce_xCuO_4の大型単結晶育成と還元条件
- 12a-X-5 Pr_Ce_xCuO_4の単結晶育成と静的物性
- Soft Phonons and Structural Phase Transitions in La_Ba_CuO_4(Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- Space-Group Determination of La_2CuO_ by Conventional and Convergent-Beam Electron Diffraction
- Complete Two-Dimensional Antiferromagnetic Spin-Wave Dispersion Relation of La_2NiO_4 Determined by Chopper Spectrometer Installed at the Pulsed Neutron Source
- Analysis of Normal State Properties on the Basis of Fermi Liquid Theory : IV-A Electronic States : IV Mechanisms of Superconductivity; Theory
- Determination of Space Group and Refinement of Structure Parameters for La_2CuO_ Crystals : Condensed Matter
- Three-Dimensional Antiferromagnetic Order and Anisotropic Magnetic Properties in Bi_2CuO_4
- Heat Treatment Effects on the Superconductivity and Crystal Structure of Nd_Ce_CuO_4 Studied Using a Single Crystal
- 2p-Y-14 CoS_2は、圧力下で、2次および1次転移が起こるか?
- 8p-YG-9 ヘリコンスパッタによるCr配向膜の作製
- 高温超伝導体の物性 : 中性子
- Possibility of f-Wave Spin-Triplet Superconductivity in the CoO_2 Superconductor : A Case Study on a 2D Triangular Lattice in the Repulsive Hubbard Model
- Perturbation Theory on the Superconductivity of Heavy Fermion Superconductors CeIr_xCo_In_5
- Rough Surface Effect on Meissner Diamagnetism in Normal-Layer of N-S Proximity-Contact System
- Rough Surface Effects on d-Wave Superconductors
- Strong Correlation Between Field-induced Magnetism and Superconductivity in Pr_LaCe_CuO_4(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Magnetic Ground State of Pr_LaCe_CuO_ with Varied Oxygen Depletion Probed by Muon Spin Relaxation
- Magnetic Ground State of Pr_LaCe_CuO_ with Varied Oxygen Depletion Probed by Muon Spin Relaxation
- Analysis of Superconductivity in d-p Model on Basis of Perturbation Theory(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Perturbation Analysis of Superconductivity in the Trellis-Lattice Hubbard Model(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Perturbation Theory for a Repulsive Hubbard Model in Quasi-One-Dimensional Superconductors (Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- 3p-PSA-42 遍歴型反強磁性体Crの磁気励起
- 30p-PSB-10 Crの偏極中性子散乱
- 28p-N-6 中性子散乱で見た銅酸化物関連物質の磁性
- 28p-N-6 中性子散乱で見た銅酸化物関連物質の磁性
- Root Distribution of Field-Grown Chinese Cabbage (Brassica campestris L.) under Different Fertilizer Treatment
- Root Distribution of Field-Grown Crisphead Lettuce (Lactuca sativa L.) under Different Fertilizer and Mulch Treatment
- Improved Method for Easy and Rapid Determination of Root Length of Vegetables
- Fermi Liquid Theory on Heavy Electron Systems
- Spin Dynamics on Two-Dimensional Heisenberg Antiferromagnets : High Energy Neutron Inelastic Scattering from La_2CuO_4 and La_2NiO_4
- Hole Doping Effect on 2D Spin Correlations in La_2NiO_
- Anomalous Hall Effect in Sr_2RuO_4
- Theory of the Magnetic Susceptibility and the Anomalous Hall Effect in Orbitally Degenerate (J = 5/2) Periodic Anderson Model
- Theory of Anomalous Hall Effect in a Heavy Fermion System with a Strong Anisotropic Crystal Field
- Theory of the Hybridization Gap in Ce Compounds with Crystalline Electric Field Splitting
- Spin-Wave Excitations in Two Dimensional Antiferromagnet of Stoichiometric La_2NiO_4
- Reproducibility in Single-Crystal Growth of 2-1-4 Type Cuprates and Nickelates by Floating Zone Method : I-C Single Crystal Growth : I. Oxide Superconductors, Experiments I : Material Syntheses and Crystal Structures
- Static Spin Correlation in LTT Phase of La1.875Ba0.075Sr0.05CuO4 (Proceedings of the 1st International Symposium on Advanced Science Research(ASR-2000), Advances in Neutron Scattering Research)
- 14a-DD-4 [Pt(en)_2][Pt(en)_2Cl_2](ClO_4)_4と関連物質の中性子回折・散乱
- Possibility of f-Wave Spin-Triplet Superconductivity in the CoO_2 Superconductor : A Case Study on a 2D Triangular Lattice in the Repulsive Hubbard Model(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Theory on Superconducting Transition from Pseudogap State : Condensed Matter: Electronic Properties, etc.
- Theory on Pseudogap State and Superconducting State in Strong Coupling Superconductors : Condensed Matter: Electronic Properties, etc.
- Irreducible constant mean curvature 1 surfaces in hyperbolic space with positive genus
- A new growth mechanism of polar nanoregions by phonon-relaxation mode-coupling in a relaxor ferroelectric
- Electroinic Structure and Transition Temperature of the d-p Model
- Temperature Dependence of Electrical Resistivity in Two-Dimensional Fermi Systems
- 銅酸化物高温超伝導体の結晶構造と磁気構造 (構造揺らぎと超伝導)