Antidiabetic Effects of Corosolic Acid in KK-Ay Diabetic Mice(Pharmacognosy)
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概要
- 論文の詳細を見る
The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4h after a single oral dose. CA (2 mg/kg) reduced the blood glucose levels in KK-Ay mice 2 weeks after a single oral dose and also significantly lowered plasma insulin levels were in KK-Ay mice under similar conditions. CA-treated KK-Ay mouse blood glucose significantly decreased in an insulin tolerance test. These results support the hypothesis that CA improves glucose metabolism by reducing insulin resistance. Therefore CA may be useful for the treatment of type 2 diabetes.
- 公益社団法人日本薬学会の論文
- 2006-03-01
著者
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Yamada Koutaro
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine
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三浦 俊宏
鈴鹿医療科学大学
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ISHIDA Torao
Hi-tech Research Center, Suzuka University of Medical Science
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MIURA Toshihiro
Department of Internal Medicine, School of Medicine, Tokai University
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Seino Yutaka
Department of Cardiology, Kansai Electric Power Hospital
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Seino Y
Department Of Diabetes And Clinical Nutrition Kyoto University Graduate School Of Medicine:kansai El
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Ishida Torao
Hi-tech Res. Center Suzuka Univ. Of Medical Sci.
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Kaneko Tetsuo
Department Of Pharmaceutical Science Hiroshima International University
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Miura T
Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm
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Miwa T
The 6th Department Of Internal Medicine School Of Medicine Tokai University
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三浦 俊宏
Suzuka University of Medical Science and Technology
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UEDA Naoya
Use Techno Corporation Co. Ltd.
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YAMADA Koutaro
Use Techno Corporation Co. Ltd.
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FUKUSHIMA Mitsuo
Department of Health Informatics Center Foundation for Biomedical Research and Innovation
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MATSUYAMA Futoshi
Use Techno Corporation Co. Ltd.
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三浦 俊宏
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Kaneko T
Department Of Pharmaceutical Science Hiroshima International University
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Seino Y
Division Of Diabetes And Clinical Nutrition Kansai Electric Power Hospital
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Seino Yutaka
Department Of Cardiology Kansai Electric Power Hospital
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Seino Yutaka
Division Of Diabetes And Clinical Nutrition Kansai-denryoku Hospital
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Miura T
Department Of Internal Medicine School Of Medicine Tokai University
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Miura Toshihiro
Department Of Clinical Nutrition Suzuka University Of Medical Science
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Miura Tsutomu
Research Sections Sanwa Shoyaku Co. Ltd.
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