Clinical Investigations in Patients with Juvenile Gastric Atrophy Compared with Senile Gastric Atrophy

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Juvenile atrophy (JA; under 30 years of age with a MAO value below 6.0mEq/h) was studied clinically in comparison senile atrophy (SA; over 60 years of age with a MAO value below 6.0mEq/h). Items examined were as follows: 1. subjective gastrointestinal symptoms, 2. gastric endoscopic findings, 3. peripheral blood lymphocyte counts, 4. PPD and DNCB skin tests, 5. HLA phenotype, 6. serum complements, 7. parietal cell antibody (PCA), 8. endoscopic congo-red pattern, 9. gastric emptying, and 10. endoscopic methylene blue method. The folloowing results were obtained: 1. GI symptoms were found more frequently in JA than in SA. The endoscopic findings of JA were a hyperplastic change of the gastric mucosa while those of SA were uneven color and transparent vessels. 2. Peripheral lymphocyte counts were lower in JA than in SA, in spite of the age difference of 40 years. In the skin tests (PPD and DNCB), JA was positive more frequently than SA. JA showed lower C3 values for serum complements. 3. In the study of HLA antigen, JA without intestinal metaplasia had low frequencies of A9 and B15 and high frequencies of BW52 and BW54. Three out of 27 cases of JA were positive for parietal cell antibodies. 4. Endoscopic congo-red patterns were mainly of the C2-C3 type in JA but of the O2 type in SA. Also by the endoscopic methylene blue method, intestinal metaplasia was not found in 11 cases with JA, but in only two cases with SA.
東海大学の論文