DIRECT EFFECT OF PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY ON THE HEART IN PATIENT WITH PERIPHERAL ARTERY DISEASE
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概要
- 論文の詳細を見る
Background and Purpose : The patient with peripheral artery disease (PAD) is known to have a poor prognosis for life. Recently, it has been reported that percutaneous transluminal angioplasty (PTA) for PAD improves the prognosis. However, the detailed mechanisms remain unclear.Augmentation index (AIx) or central aortic pressure (CAP) is shown to increase myocardial mechanical stress and facilitate myocardial hypertrophy. The aim of this study is to clarify the direct cardioprotective effects of PTA mediated by decreasing CAP and AIx.Methods : 28 patients with PAD were enrolled. They were divided into two groups ; control group (n=12) and PTA group (n=16). Both radial AIx and CAP were measured by using pulse waveform analysis of arterial waveform recorded non-invasively by applanation tonometry in radial artery. We used a plasma B-type natriuretic peptide (BNP) level as a marker of myocardial mechanical stress. Plasma BNP levels, radial AIx and CAP which were measured after PTA or angiography, were compared with the data on admission.Result : Although plasma BNP levels in the control group were not changed, those in the PTA group were significantly decreased from 68.44 to 42.08 pg/ml (p<0.05). Pulse waveform analysis demonstrated that radial AIx and CAP in the control group remain unchanged. On the other hand, radial AIx and CAP were significantly reduced in the PTA group. The reduction rates of radial AIx, CAP and plasma BNP levels were −11.3%, −8.9% and −34% respectively.Conclusion : These results suggest that PTA can decrease myocardial mechanical stress in patients with PAD. The mechanisms may be mediated in part by reduction of radial AIx and CAP.
- 秋田大学の論文
著者
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WATANABE Hiroyuki
Department of Internal Medicine, Division of Cardiovascular Medicine, Akita University Faculty of Me
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KOSAKA Toshimitsu
Department of Internal Medicine, Division of Cardiovascular Medicine, Akita University Faculty of Me
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HASEGAWA Hitoshi
Department of Internal Medicine, Division of Cardiovascular Medicine, Akita University Faculty of Me
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ITO Hiroshi
Department of Internal Medicine, Division of Cardiovascular Medicine, Akita University Faculty of Me
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Iino Kenji
Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine
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Watanabe Hiroyuki
榊原記念病院 心臓血管外科
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Ito Hiroyuki
Department Of Internal Medicine Division Of Cardiovascular And Respiratory Medicine Akita University
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Iino Kenji
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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Iino Kenji
Department Of Cardiology Akita Redcross Hospital
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Kosaka Toshimitu
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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Watanabe Hiroyuki
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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OGUMA Yasunori
Department of Cardiovascular and Respiratory Medicine,Akitai University Graduate School of Medicine
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Haswgawa Hitoshi
Department Of Internal Medicine Division Of Cardiovascular And Respiratory Medicine Akita University
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Hasegawa Hitoshi
Department Of Bioregulatory Medicine Ehime University Graduate School Of Medicine
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Ito Hiroshi
Department Of Cardiovascular And Respiratory Medicine Akita University Graduate School Of Medicine
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Hasegawa Hitoshi
Second Dept. Of Internal Medicine Akita University
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Oguma Yasunori
Department Of Cardiovascular And Respiratory Medicine Akitai University Graduate School Of Medicine
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Watanabe Hiroyuki
Department Of Cardiology Akita University School Of Medicine
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Watanabe Hiroyuki
Department Of Internal Medicine Division Of Cardiovascular And Respiratory Medicine Akita University
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Ito Hiroshi
Department Neurosurgery Tokyo Medical College
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Watanabe Hiroyuki
Department Of Agricultural Chemistry Ibaraki University
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Kosaka Toshimitsu
Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine
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