Histamine Synthesis after Administration of Gastrin and Blockade of Acid Secretion in the Rat Stomach

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概要

• 論文の詳細を見る

• Histidine decarboxylase (HDC) activity in the oxyntic gland and gastric volume were measured in rats treated with tetragastrin, cimetidine or omeprazole. HDC activity was dose dependently activated by not only tetragstrin but also cimetidine and omeprazole treatment. Histamine concentration in the oxyntic gland was reduced, but the amount of histamine in the gastric contents was increased by tetragastrin treatment. In rats premedicated with cimetidine or omeprazole, histamine concentration in the oxyntic gland and the amount of histamine in the gastric contents were not changed by administration of tetragastrin. It was concluded that tetragastrin activated HDC which increased histamine release into the gastric contents. Cimetidine and omeprazole induced the secretion of endogeneous gastrin, leading to the activation of HDC.

• 東海大学の論文

著者

• Miwa Takeshi

  Department Of Internal Medicine School Of Medicine Tokai University

• HARASAWA Shigeru

  Division of Gastroenterology II, Tokai University School of Medicine

• KONAGAYA Minoru

  Department of Internal Medicine, Tokai University School of of Medicine

• HARASAWA Shigeru

  Department of Internal Medicine, Tokai University School of of Medicine

• MATSUMOTO Masahiko

  Department of Biochemistry, School of Medicine, Tokai University

• Miwa Masahiko

  Department Of Internal Medicine School Of Medicine Tokai University

• Miura T

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Miwa T

  The 6th Department Of Internal Medicine School Of Medicine Tokai University

• Miwa Masahiko

  Endoscopic Center School Of Medicine Tokai University

• Matsumoto Masahiko

  Department Of Biochemistry School Of Medicine Tokai University

• Matsumoto M

  Department Of Biochemistry School Of Medicine Tokai University

• Miwa Takeshi

  The 6th Department Of Internal Medicine School Of Medicine Tokai University

• Harasawa Shigeru

  Department Of Internal Medicine School Of Medicine Tokai University

• Harasawa S

  Tokai Univ. School Of Medicine Isahara Jpn

• Harasawa Shigeru

  Division Of Gastroenterology Ii Tokai University School Of Medicine

• Harasawa Shigeru

  Department Of Gastroenterology Ii Tokai University School Of Medicine

• Miwa Takeshi

  Department Of Internal Medicine 6 Tokai University School Of Medicine

• Miura T

  Department Of Internal Medicine School Of Medicine Tokai University

• Konagaya Minoru

  Department Of Internal Medicine Tokai University School Of Of Medicine

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