Collagen and Collagenase in Ulcer Tissue-1. The Healing Process of Acetic Acid Ulcers in Rats
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概要
- 論文の詳細を見る
We have reported that collagenase activity of the gastric mucosa increased significantly in acetic acid ulcers of dogs (2). The present study revealed that acetic acid ulcers in rats showed that the active collagenase level in the ulcer tissue increased rapidly with a peak (412.5%) on the 3rd day after induction of the acetic acid ulcer. Thereafter, the collagenase activity levels decreased gradually by the 7th day and returned practically to the control levels by the 14th day. On the other hand, collagen (hydroxyproline content) decreased by the 7th day (-16.5%) and recovered by the 14th day after induction of the acetic acid ulcer. The peak of active collagenase on the 3rd day coincident with the maximum ulcer index, suggesting involvement of collagenase activity in ulceration. In addition, destruction and production of collagen are considered to take place not only at the base of the ulcer and its margin, but also along its circumference.
- 東海大学の論文
著者
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Miwa Takeshi
Department Of Internal Medicine School Of Medicine Tokai University
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HARASAWA Shigeru
Division of Gastroenterology II, Tokai University School of Medicine
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HARASAWA Shigeru
Department of Internal Medicine, Tokai University School of of Medicine
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Miwa T
Division Of Gastroenterology Ii Tokai University School Of Medicine
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HASEBE Tetsunori
Division of Gastroenterology II, Tokai University School of Medicine
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HASEBE Tetsunori
Department of Internal Medicine, School of Medicine, Tokai University
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SHIBATA Tetsuichi
Pharmaceutical Institute, School of Medicine, Keio University
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INAYAMA Seiichi
Pharmaceutical Institute, School of Medicine, Keio University
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Harasawa S
Tokai Univ. School Of Medicine Isahara Jpn
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Harasawa Shigeru
Department Of Gastroenterology Ii Tokai University School Of Medicine
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Hasebe T
Division Of Gastroenterology Ii Tokai University School Of Medicine
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Hasebe Tetsunori
Department Of Internal Medicine School Of Medicine Tokai University
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Shibata Tetsuichi
Pharmaceutical Institute School Of Medicine Keio University
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Miwa Takeshi
Department Of Internal Medicine 6 Tokai University School Of Medicine
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Inayama Seiichi
Pharmaceutical Institute School Of Medicine Keio University
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