Estimation of the Functional Reserve of the Human Liver by Urinary D-Glucaric Acid Excretion after Vitamin C Administration
スポンサーリンク
概要
- 論文の詳細を見る
The excretion of D-glucaric acid in the urine (uGA) correlates with the total liver content of hepatic cytochrome P-450, the metabolism of which depends on adenosine triphosphate (ATP) being produced by intrahepatic cellular mitochondria. Five cases of compensated liver cirrhosis group with less than 0.4 mg/kg/min of the maximum removal rate of indocyanine green (ICGR max), and 5 cases with normal hepatic function (control group), were monitored for uGA before and after P-450 activation induced by administration of Ig of vitamin-C. Before vitamin-C administration, no differences in uGA excretion were observed comparing the cirrhosis with the control group. After administration of vitamin-C, the excretion of uGA was significantly lower in the cirrhosis group. The measurement of uGA is considered to represent vitamin-C induced activation by P-450, and is a new method for evaluation of the functional reserve of the liver.
- 東海大学の論文
著者
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Miwa Takeshi
Department Of Internal Medicine School Of Medicine Tokai University
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MITOMI Toshio
Department of Surgery, School of Medicine, Tokai University
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MUKAI Masaya
Department of Surgery, Tokai University Oiso Hospital
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Mitomi Toshio
Department Of Surgery (division Of Pediatric Surgery) Tokai University School Of Medicine
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Mukai M
Department Of Surgery Tokai University School Of Medicine
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Mukai Masaya
東海大学医学部附属八王子病院 外科
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Mukai Masaya
Division Of Immunology And Hematology Department Of Medicine Sapporo City General Hospital
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Miwa T
Tokai Univ. School Of Medicine Kanagawa Jpn
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Mukai M
Keio Univ. School Of Medicine Tokyo Jpn
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Tajima Tomoo
Department Of Surgety Tokai University School Of Medicine
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Tajima Tomoo
Department Of 2nd Surgery School Of Medicine Tokai University
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Tajima Tomoo
Department Of Surgery Tokai University School Of Medicine
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NAKASAKI Hisao
Department of General Surgery, School of Medicine, Tokai University
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Tobita Kohsuke
Department Of Surgery Tokai University Oiso Hospital
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Mukai Masaya
Department Of Clinical Immunohematology Sapporo City General Hospital
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HANAUE Hitoshi
Departments of Surgery Tokai University Oiso Hospital
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Mukai Makio
Department Of Pathology Therapeutic Endoscopy School Of Medicine Keio University Shinjuku-ku
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Hirakawa Hitoshi
Department Of Pediatric Surgery Gastrointestinal Surgery And Radiology Tokai University School Of Me
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Nakasaki Hisao
Department Of Surgery Tokai University Oiso Hospital
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Nakasaki H
Department Of Surgery Tokai University School Of Medicine
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Nakazaki Hisao
Department Of Pathology School Of Medicine Tokai University
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Machimura Takao
Second Department Of Surgery Tokai University School Of Medicine
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Mitomi Toshio
Second Department Of Surgery Tokai University School Of Medicine
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Mitomi T
Department Of Surgery Tokai University School Of Medicine
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Mitomi Toshio
Department Of 2nd Surgery School Of Medicine Tokai University
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KANNO Kohshi
Department of Surgery, Tokai University Oiso Hospital
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KUBO Hirotsugu
Department of Surgery, Tokai University Oiso Hospital
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ENDO Ryohichi
Central Clinical Laboratory, Mishuku Hospital
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Mukai M
Sapporo City General Hospital
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Kondo K
Department Of Surgery Tokai University Oiso Hospital
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Endo Ryohichi
Central Clinical Laboratory Mishuku Hospital
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Kubo Hirotsugu
Department Of Surgery Tokai University Oiso Hospital
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Kubo Hirotsugu
Department Of Physics Kyoto University
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Nakasaki H
Department Of Surgery Tokai University Oiso Hospital
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HANAUE HITOSHI
Department of Surgery, Fujita-Gakuen University School of Medicine
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Miyashita Kayoko
DIMS Institute of Medical Science:Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences
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