Relation between Esophagogastric Junction and Esophageal Function in Patients with Reflux Esophagitis

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概要

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• The relationship between the esophagogastric junction (Z-line pattern) and the functions of the esophagus was studied in patients with reflux esophagitis. We classified Z-line patterns as the Z_0-type to Z_4-type, depending on the shape and the level of the Z-line. Lower esophageal sphincter pressure (LESP) was measured by the open-tip infusion method and the acid clearance test was performed by Booth's method (15ml of 0.1 N HCL). The following results were obtained: 1. LESP was 15.5±5.6cmH_2O (M±SD) in normal subjects (Z_0-type), it was 10.3±2.9 cmH_2O in the Z_1-type, 9.5±4.9cmH_2O in the Z_2-type, 9.4±4.1cmH_2O in the Z_3-type and 7.6±3.4cmH_2O in the Z_4-type. There were statistically significant differences between the Z_0-type and the other Z-line patterns (p<0.05, P<0.05, P<0.025, and P<0.025, respectively). 2. Acid clearance was expressed as the time until the pH returned to 5.0 due to swallowing at oneminute intervals. The results of the acid clearance test were 11.4±3.0 min in the Z_0-type 18.3±7.0 min in the Z_1-type, 20.3±5.6 min in the Z_2-type, 24.1±5.7 min in the Z_3-type and 24.5±7.4 min in the Z_4-type. Acid clearances were significantly delayed along with the Z-line pattern (P<0.025, P<0.005, P<0.005 and P<0.005, respectively). 3. The patients with hiatal hernia consisted of five cases of the Z_3-type and six cases of the Z_4-type. They had low LESP and delayed acid clearance. As mentioned above, the results of LESP ad acid clearance test were well correlated with Z-line patterns in patients with reflux esophagitis.

• 東海大学の論文

著者

• Miwa Takeshi

  Department Of Internal Medicine School Of Medicine Tokai University

• Kikuchi Kazuhiro

  Department Of Internal Medicine School Of Medicine Tokai University

• Kikuchi Kazuhiro

  東海大学 内科

• HARASAWA Shigeru

  Department of Internal Medicine, Tokai University School of of Medicine

• SENOUE Issei

  Department of Internal Medicine, School of Medicine, Tokai University

• NOMIYAMA Tetsu

  Department of Internal Medicine, School of Medicine, Tokai University

• SHIBATA Harumichi

  Department of Internal Medicine, Shcool of Medicine, Tokai University

• MAKINO Takashi

  Department of Internal Medicine, Shcool of Medicine, Tokai University

• MIWA Masahiko

  Department of Internal Medicine, Shcool of Medicine, Tokai University

• SUZUKI Sohtaro

  Department of Internal Medicine, Shcool of Medicine, Tokai University

• TANI Norio

  Department of Internal Medicine, Shcool of Medicine, Tokai University

• Tamaoki N

  Central Inst. For Experimental Animals

• Miwa Masahiko

  Department Of Internal Medicine School Of Medicine Tokai University

• Tani Norio

  Department Of Internal Medicine School Of Medicine Tokai University

• Tani N

  The 6th Department Of Internal Medicine School Of Medicine Tokai University

• Suzuki Sotaro

  Department Of Internal Medicine School Of Medicine Tokai University

• Miwa Masahiko

  Department Of Biochemistry School Of Medicine Tokai University

• Nomiyama Tetsu

  Department Of Internal Medicine School Of Medicine Tokai University

• Tani Norio

  6th Department Of Internal Medicine School Of Medicine Tokai University

• Tani Norio

  The 6th Department Of Internal Medicine School Of Medicine Tokai University

• Miura T

  Laboratory For Immunopharmacology Of Microbial Products School Of Pharmacy Tokyo University Of Pharm

• Miwa T

  The 6th Department Of Internal Medicine School Of Medicine Tokai University

• Kikuchi Kazuhiro

  Department Of Animal Science National Institute Of Agrobiological Sciences

• Miwa Masahiko

  Endoscopic Center School Of Medicine Tokai University

• Tamaoki Norikazu

  Central Inst. For Experimental Animals

• Matsumoto M

  Department Of Biochemistry School Of Medicine Tokai University

• Mitomi Toshio

  Second Department Of Surgery Tokai University School Of Medicine

• Miwa Takeshi

  The 6th Department Of Internal Medicine School Of Medicine Tokai University

• Senoue Issei

  Department Of Internal Medicine School Of Medicine Tokai University

• Makino Takashi

  Department Of Applied Physics Graduate School Of Engineering Yokohama National University

• Suzuki Sohtaro

  Department Of Internal Medicine School Of Medicine Tokai University

• Harasawa Shigeru

  Department Of Internal Medicine School Of Medicine Tokai University

• Harasawa Shigeru

  Division Of Gastroenterology Ii Tokai University School Of Medicine

• Harasawa Shigeru

  Department Of Gastroenterology Ii Tokai University School Of Medicine

• Miwa Takeshi

  Department Of Internal Medicine 6 Tokai University School Of Medicine

• Shibata Harumichi

  Department Of Internal Medicine School Of Medicine Tokai University

• SUZUKI Sohtaro

  Department of Hospital Administration, School of Medicine, Tokai University

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