Hemolytic Streptococcus Preparation OK-432; Benefical Adjuvant Therapy in Recurrent Gastric Carcinoma
スポンサーリンク
概要
- 論文の詳細を見る
The administration of a hemolytic streptococcus preparation, OK-432, is thought to be of therapeutic value in the treatment of cancer patients through a stimulatory effect on the immune system. In order to evaluate any beneficial effect of such an administration, a group of patients with recurrent gastric cancer was studied. This group was randomly subdivided into 3 groups: 1) Intradermal group (ID Group), 42 patients given an intradermal injections of OK-432. 2) Intramuscular group (IM Group), 40 patients given an intramuscular injections of OK-432. 3) Control group (C Group), 39 patients not given injections. Each group was studied in regards to the length of survival, the host immune response and the incidence of side effects. When compared to the IM and C Groups, the ID Group showed improved survival. Accompanying this improved survival, the ID Group also had greater white cell and lymphocyte counts, a greater number of T cells, and a more dramatic skin reaction to the extracted cell wall polysaccharide of hemolytic streptococcus Su-strain (Su-PS). The ID Group, following OK-432 injection, had a 4.8% incidence of fever and a 52.4% incidence of local abscess formation at the injection site. 90% of the IM Group developed fever but abscess formation was absent in all patients. From these results, it was concluded that in the patients tested, intradermal injection of OK-432 appears to be clinically superior to intramuscular injection.
- 東海大学の論文
著者
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Ogoshi Kyoji
Department of Gastroenterological Surgery, Tokai University
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Miwa Takeshi
Department Of Internal Medicine School Of Medicine Tokai University
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KIM Dae
Department of Anatomy and Center for Advanced Medical Education by BK21 Project, Inha University Col
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MITOMI Toshio
Department of Surgery, School of Medicine, Tokai University
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Mitomi Toshio
Department Of Surgery (division Of Pediatric Surgery) Tokai University School Of Medicine
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MAKUUCHI HIROYASU
Department of Cardiovascular Surgery, Tokai University Hospital
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Kondoh Yasumasa
Department of Surgery, Tokai University School of Medicine
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Miwa T
Tokai Univ. School Of Medicine Kanagawa Jpn
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Ogoshi K
Tokai Univ. School Of Medicine
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Ogoshi Kyoji
Department Of Surgery School Of Medicine Tokai University
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Kim Dae
Department Of Surgery Tokai University Oiso Hospital
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Kim Dae
Infocom Eng. Dept. Chungnam National University
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KUBOTA Mitsuhiro
Department of General Surgery, School of Medicine, Tokai University
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NAKASAKI Hisao
Department of General Surgery, School of Medicine, Tokai University
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Shikata Jun-ichi
The 1st Department Of Surgery School Of Medicine Teikyo University
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TSUKUI Masaru
Department of Surgery, Tokai Univ. School of Medicine
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HANAUE Hitoshi
Departments of Surgery Tokai University Oiso Hospital
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Kondoh Yasumasa
Department Of Surgery Tokai University Tokyo Hospital
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Kondoh Yasumasa
Department Of Surgery School Of Medicine Tokai University
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Makuuchi Hiroyasu
Department Of Cardiovascular Surgery Tokai University Hospital
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Kim Dae
Department Of Anatomy And Center For Advanced Medical Education By Bk21 Project Inha University Coll
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Tsukui Masaru
Department Of Surgery Tokai Univ. School Of Medicine
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Hirakawa Hitoshi
Department Of Pediatric Surgery Gastrointestinal Surgery And Radiology Tokai University School Of Me
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Nakasaki Hisao
Department Of Surgery Tokai University Oiso Hospital
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Nakasaki H
Department Of Surgery Tokai University School Of Medicine
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Nakazaki Hisao
Department Of Pathology School Of Medicine Tokai University
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MACHIMURA Takao
Department of Surgery, Tokai University Oiso Hospital
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KUROSAWA Tsutomu
The 1st Department of Surgery, School of Medicine, Teikyo University
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Machimura Takao
Second Department Of Surgery Tokai University School Of Medicine
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Mitomi Toshio
Second Department Of Surgery Tokai University School Of Medicine
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Mitomi T
Department Of Surgery Tokai University School Of Medicine
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Mitomi Toshio
Department Of 2nd Surgery School Of Medicine Tokai University
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Murakami T
Department Of Critical Care And Emergency Medicine Tokai University School Of Medicine
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Kubota Mitsuhiro
Department Of Surgery Tokai University School Of Medicine
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Kubota Mitsuhiro
Department Of Surgery Tokai University Oiso Hospital
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Kubota Mitsuhiro
Department Of Energy Engineering And Science Nagoya University
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Maruyama H
Department Of Surgery Tokai University School Of Medicine
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Machimura Takao
Department Of Surgery Tokai University School Of Medicine
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Kurosawa Tsutomu
Institute For Experimental Animal Sciences Osaka University Medical School
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Nakasaki H
Department Of Surgery Tokai University Oiso Hospital
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Kubota Mitsuhiro
Department of Energy Engineering & Science, Nagoya University
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Kondoh Yasumasa
Department of Gastroenterological Surgery, Tokai University
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HANAUE HITOSHI
Department of Surgery, Fujita-Gakuen University School of Medicine
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Miyashita Kayoko
DIMS Institute of Medical Science:Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences
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