近位尿細管細胞におけるグルココルチコイドによる分極性膜性輸送の制御機構 : Ca^<2+>の関与
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概要
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私達はグルココルチコイドの刷子縁膜輸送体に対する効果,および近位尿細管細胞の初代培養細胞におけるその効果へのCa^<2+>の関与について検討した.デキサメサゾン(10^<-9>M)はPiの再吸収を17%まで抑制したが,α-メチルグルコピラノサイドやNa^+の再吸収には影響しなかった.デキサメサゾンによるPi再吸収はVmaxの減少によるものであった.一方,他のステロイドホルモンであるプロゲステロン,テストステロンおよび17β-エストラダイオール(10^<-9>M)にはPi再吸収の抑制は示されなかった.デキサメサゾンによるPi再吸収に対するCa^<2+>の関与について検討するため,A23187(10^<-6>M,Ca^<2+>イオノフォア)処置を行った.A23187はデキサメサゾンによるPi再吸収を模倣する様にPi再吸収を抑制した.W7(10^<-4>M,カルモジュリン依存性キナーゼ阻害薬),KN-62(10^<-6>M,Ca/カルモジュリン依存性プロテインキナーゼ 阻害薬),BAPTA/AM(10^<-6>M),TMB-8(10^<-4>M)(細胞内Ca^<2+>動員阻害薬)はデキサメサゾンによるPi再吸収を阻止した.しかしながら,nifedifine,methoxyverapamil(10^<-6>M,L型Ca^<2+>チャンネル阻害薬)やEGTA(1mM,細胞外Ca^<2+>キレーター)はそれを阻止しなかった.即ち,デキサメサゾンは近位尿細管において,一部,細胞内Ca^<2+>動員によって仲介されるCa/カルモジュリン経路を介してPiの再吸収を抑制している.
著者
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PARK Soo
Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University
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KIM Dae
Department of Anatomy and Center for Advanced Medical Education by BK21 Project, Inha University Col
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HAN Ho
Department of Veterinary Physiology, College of Veterinary Medicine, Hormone Research Center, Chonna
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LEE Young
College of Veterinary Medicine, Seoul National University
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LEE Jang
College of Veterinary Medicine, Seoul National University
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YANG Il
College of Veterinary Medicine, Seoul National University
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Han Ho
Hormone Res. Center And Coll. Of Veterinary Medicine Chonnam National Univ. Gwang-ju Kor
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Han Ho
Department Of Veterinary Physiology College Of Veterinary Medicine Chonnam National University
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Lee Jang
College Of Veterinary Medicine Seoul National University
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Kim Dae
Department Of Anatomy And Center For Advanced Medical Education By Bk21 Project Inha University Coll
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Yang Il
College Of Veterinary Medicine Seoul National University
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Park Soo
Department Of Aquatic Life Medicine College Of Fisheries Science Pukyong National University
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Kim Dae
Department Of Veterinary Physiology College Of Veterinary Medicine Hormone Research Center Chonnam N
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Lee Young
College Of Bioscience Institute Of Biotechnology Department Of Bioscience And Biotechnology Sejong U
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Lee Young
College Of Veterinary Medicine Seoul National University
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Park Soo
Department Of Veterinary Physiology College Of Veterinary Medicine Hormone Research Center Chonnam N
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