Synthesis and PPAR-γ Ligand-Binding Activity of the New Series of 2'-Hydroxychalcone and Thiazolidinedione Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
Fifteen chalcones and three thiazolidinedione (TZD) chalcones were prepared to evaluate their peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand-binding activities. Among the three TZDs, one compound possessed PPAR-γ transactivation potential, while the others showed antagonistic activity against PPAR-γ transactivation. Among the chalcones, compound 5 was the most potent, and structure-activity relationship studies indicated that a methoxyl group in position C-4 and hydroxyl group in position C-4' or 5' in chalcone plays a key role in determining the potency of PPAR-γ activation.
- 公益社団法人日本薬学会の論文
- 2006-03-01
著者
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PARK Soo
Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University
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Jung Sang
Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institu
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Kim Yeong
Natural Products Research Institute College Of Pharmacy Seoul National University
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Kim Yeong
Natural Products Res. Inst. Coll. Of Pharmacy Seoul National Univ.
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LEE Hong
Department of Family Medicine, School of Medicine, Ewha Womans University
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PARK Kyong
Department of Internal Medicine, Seoul National University College of Medicine
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Kim Y
Seoul National Univ. Seoul Kor
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Shin Hyun-kyung
Department Of Food Science And Nutrition Hallym University:regional Innovation Center Hallym Univers
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Shin Hyun-kyung
韓国
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Lim Soon
Dep. Of Food Sci. And Nutrition Hallym Univ.
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Lim Soon
韓国
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Lim Soon
Department Of Food Science And Nutrition Silver Biotechnology Research Center Hallym University
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Jung Sang
Natural Products Res. Center Korea Inst. Of Sci. And Technol. (kist) Gangneung Inst.
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Lee Hong
Dep. Of Internal Medicine Eulji Univ. Medical Coll.
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Park Kyong
Dep. Of Internal Medicine Seoul National Univ. Coll. Of Medicine
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Jung Sang
Natural Products Research Center Korea Institute Of Science And Technology (kist) Gangneung Institut
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Ban Hyun
Center For Efficacy Assessment And Dev. Of Functional Foods And Drugs Hallym Univ.
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Park Kyong
Department Of Internal Medicine Seoul National University College Of Medicine
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Kim-pak Youngmi
Department Of Biochemistry Ulsan University College Of Medicine
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Lim Soon
Department Of Food Science And Nutrition Hallym University:regional Innovation Center Hallym Univers
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SHIN Kuk
Korea Institute of Science and Technology Information
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OHUCHI Kazuo
Graduate School of Pharmaceutical Sciences, Tohoku University
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SHIN Kuk
Natural Products Research Institute, Seoul National University, Republic of Korea
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SHIN Hyun-Kyung
Silver Biotechnology Research Center, Hallym University
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KEUM Sam
Department of New Material Chemistry, Korea University
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LIM Soon
Silver Biotechnology Research Center, Hallym University
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Jung Sang
韓国
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Park Soo
Department Of Aquatic Life Medicine College Of Fisheries Science Pukyong National University
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Ohuchi Kazuo
Faculty Of Pharmacy Yasuda Women's University
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Park Soo
Department Of Biochemistry Ulsan University College Of Medicine
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Keum Sam
Department Of New Material Chemistry Korea University
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Lee Hong
Department Of Ceramic Engineering Yonsei University
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Lee Hong
Department Of Bio-resources And Pnu-special Animal Biotechnology Center College Of Natural Resources & Life Science Pusan National University
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SHIN Kuk
Natural Products Research Institute, Seoul National University
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