Upregulation of Cellular NF-кB Activity by Alkylating Carcinogens in Human Epidermal Keratinocytes(Toxicology)
スポンサーリンク
概要
- 論文の詳細を見る
Effect of alkylating carcinogens, i.e., N-nitroso-N-methylurea (NMU) and N-nitroso-N-ethylurea (NEU), as well as the simpler alkylating agents, methyl iodide and ethyl iodide, on the activation of NF-кB was evaluated in human epidermal squamous cell carcinoma (SCC-13) keratinocytes in order to investigate the possible correlation of cellular NF-кB activity with chemical carcinogenesis. The activities of NF-кB induced by chemical carcinogens were determined in human SCC-13 keratinocytes transfected with pNF-кB-SEAP-NPT plasmid, permitting expression of the secretory alkaline phosphatase (SEAP) reporter gene in response to the NF-кB activity and contains the neomycin phosphotransferase (NPT) gene conferring resistance to the geneticin. In this cellbased assay system, all alkylating carcinogens significantly upregulated the cellular NF-кB activations in a time-and dose-dependent manner until 72 h, at concentrations of 0.5-5 μM. These results suggest that carcinogenicity by alkylating chemicals may be associated with the modulation of cellular NF-кB activity in human skin cells.
- 公益社団法人日本薬学会の論文
- 2003-08-01
著者
-
Kim Yeong
Natural Products Res. Inst. Coll. Of Pharmacy Seoul National Univ.
-
Moon Ki-young
Department Of Clinical Pathology And Bioindustry And Technology Research Institute Kwangju Health Co
-
Lee Young
Department Of Clinical Pathology And Bioindustry And Technology Research Institute Kwangju Health Co
-
Lee Young
Department Of Aerospace Information Engineering The Konkuk University
関連論文
- Isolation and Characterization of Chondroitin Sulfates from Sturgeon (Acipenser sinensis) and Their Effects on Growth of Fibroblasts
- 脳脊髄液と血清から抗甲状腺抗体が検出された無飲症性高ナトリウム血症の犬の1例(内科学)
- Protective Effect of Baicalin Against Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice
- Protective Effects of Broccoli (Brassica oleracea) and Its Active Components against Radical-Induced Oxidative Damage
- A Mutation of the Glucocorticoid Receptor Gene in Patients with Systemic Lupus Erythematosus
- P3-IS-43 DSCR expression in the preeclamptic placentas(Group89 Perinatology+Women's Health1,International Session)
- Evaluation of Myocardial Bridge With Multidetector Computed Tomography
- Non-A type nucleophosmin 1 gene mutation predicts poor clinical outcome in de novo adult acute myeloid leukemia : differential clinical importance of NPM1 mutation according to subtype
- Optimal binning and ROI size of the automatic classification system for differentiation between obstructive lung diseases on the basis of texture features at HRCT
- Modeling of Two-Dimensional Radio-Frequency methane Glow Discharge in Cylindrical Geometry
- CD8^+CD122^+ regulatory T cells recognize activated T cells via conventional MHC class I-αβTCR interaction and become IL-10-producing active regulatory cells
- Influence of MgO and Al_2O_3 Contents on Viscosity of Blast Furnace Type Slags Containing FeO
- Influence of Basicity and FeO Content on Viscosity of Blast Furnace Type Slags Containing FeO
- High-Order Transverse Mode Characteristics of 790 nm Vertical-Cavity Surface-Emitting Lasers
- Effects of Saponins from the Root Bark of Aralia elata on the Transport of Chondroitin Sulfate in Caco-2 Cell Monolayers and Rats(Biopharmacy)
- Antiinflammatory Activity of α-Hederin Methyl Ester from the Alkaline Hydrolysate of the Butanol Fraction of Kalopanax pictus Bark Extract
- Effects of Tegaserod on Ileal Peristalsis of Guinea Pig In Vitro
- Residual Stress Behavior of Polyimide Thin Films : Effect of Precursors
- Carbon-Nanotubes for Full-Color Field-Emission Displays
- Phase Ii study of docetaxel and cisplatin combination chemotherapy in metastatic or unresectable localized non-small-cell lung cancer
- Synthesis and PPAR-γ Ligand-Binding Activity of the New Series of 2'-Hydroxychalcone and Thiazolidinedione Derivatives
- Analysis of Multilayer Structure for Reflection of Extreme-Ultraviolet Wavelength
- Anti-angiogenic and Anti-tumor Activities of 2'-Hydroxy-4'-methoxychalcone(Pharmacology)
- Anti-inflammatory Activity of Prosapogenin Methyl Ester of Platycodin D via Nuclear Factor-kappaB Pathway Inhibition(Pharmacognosy)
- Secondary leukemia in a child conceived using in vitro fertilization
- Anti-apoptotic and Hepatoprotective Effects of Gomisin A on Fulminant Hepatic Failure Induced by D-Galactosamine and Lipopolysaccharide in Mice
- PE-082 CABG versys PCI for Left Main Disease(Coronary revascularization, PCI-8 (IHD) PE14,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Identification of genes responding to ultraviolet B irradiation in HaCaT keratinocytes cultured in vitro
- One hundred and eleven liver resections for hilar bile duct cancer
- Effects of Low Molecular Weight Chondroitin Sulfate on Type II Collagen-Induced Arthritis in DBA/1J Mice(Pharmacology)
- Evaluation of Musk by Enzyme-Linked Immunosorbent Assay
- Formation Mechanism and Pore Size Control of Light-Emitting Porous Silicorn
- Neurologic manifestations and treatment of Henoch-Schonlein purpura
- An Efficient Speech Enhancement Algorithm for Digital Hearing Aids Based on Modified Spectral Subtraction and Companding(Speech and Hearing)
- Inhibitory Effect of TNF-α and IL-8 Secretion by Pimarane-Type Diterpenoids from Acanthopanax koreanum
- The Effects of Famciclovir and Epidural Block in the Treatment of Herpes Zoster
- Altered Immune Cell Proportions in the Radiodermatitis Induced Hairless Mice-1 (HR-1)
- Polydiacetylene Supramolecules Embedded in PVA Film for Strip-type Chemosensors
- Anti-apoptotic role of S100A8 in X-ray irradiated keratinocytes
- Induction of Apoptosis by Radix Paeoniae Alba Extract through Cytochrome c Release and the Activations of Caspase-9 and Caspase-3 in HL-60 Cells(Molecular and Cell Biology)
- Efficacy of endoscopic subureteral injection for vesicoureteral reflux in adults with decreased bladder compliance
- Protective Mechanism of Glycyrrhizin on Acute Liver Injury Induced by Carbon Tetrachloride in Mice(Pharmacology)
- Anti-obesity Effect of Pinellia ternata Extract in Zucker Rats(Pharmacognosy)
- Results of operative treatment of double Morton's neuroma in the same foot
- Pitx2, a β-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro
- Robot-assisted laparoscopic radical prostatectomy in the Asian population : Modified port configuration and ultradissection
- Fabrication of Ultrafine Grained Ferrite/Martensite Dual Phase Steel by Severe Plastic Deformation
- Quantitative analysis of chondroitin sulfate in raw materials, ophthalmic solutions, soft capsules and liquid preparations
- Intraductal papillary mucinous neoplasm of the pancreas : clinical characteristics and treatment outcomes of 118 consecutive patients from a single center
- Expressional changes of ganglioside GM3 during ovarian maturation and early embryonic development in db/db mice
- Ultrastructure of Spermatozoa and Spermatogenesis in Nepomorpha (Insecta: Heteroptera) with Special Reference to Phytogeny(Cell Biology)
- Steady Shear and Viscoelastic Behaviors of Polyaniline Suspension as an Electrorheological Fluid
- Adaptive Feed-forward Automatic Gauge Control in Hot Strip Finishing Mill
- The Direct Contact Condensation of Steam in a Pool at Low Mass Flux
- Electrooptic Properties of the Two-Stage Sintered Ba (La_Nb_) O_3 -Pb (Zr, Ti) O_3 Ceramics
- A Study on Low Velocity Impact Behavior and Compressive Residual Strength of Carbon/Epoxy Composite Laminates(Composite 4)
- Dipolarity, Hydrogen-Bond Basicity and Hydrogen-Bond Acidity of Aqueous Poly(ethylene glycol)Solutions
- Perioperative complications of the MOBILITY total ankle system : comparison with the HINTEGRA total ankle system
- Effect of an Atmospheric Pressure Plasma Cleaning on the Outgassing Characteristics of MgO Layer for Plasma Display Panel
- Incessant Monomorphic Ventricular Tachycardia Associated With Pneumococcal Meningitis : A Case Report
- A New Polyoxygenated Triterpene and Two New Aeginetic Acid Quinovosides from the Roots of Rehmannia glutinosa
- A case of Ohtahara syndrome with mitochondrial respiratory chain complex I deficiency
- S-04 A New Paradigm for Molecular Toxicology : Protective Roles of p53-mediated DNA Repair under Redox Modulation against Environmental Mutagens(ACEM Symposium I:Mechanisms of environmental mutagenesis and carcinogenesis)
- ID3 mediates X-ray-induced apoptosis of keratinocytes through the regulation of β-catenin
- Theoretical Study of Ir(III) Complexes of Fluorinated Phenylbenzoquinoline as Red Phosphorescent Material
- Upregulation of Cellular NF-кB Activity by Alkylating Carcinogens in Human Epidermal Keratinocytes(Toxicology)
- Higher-Order Modes for Shielded Offset Striplines
- Core-Satellite Heterostructure of Fe_3O_4-Pd Nanocomposite : Selective and Magnetically Recyclable Catalyst for Decarboxylative Coupling Reaction in Aqueous Media
- Effect of rosmarinic acid on atopic dermatitis
- Mechanisms of carvacrol-induced expression of type I collagen gene
- Cloning and Nucleotide Sequence of Thermostable Lipase Gene from Pseudomonas fluorescens SIK W1(Biological Chemistry)
- Availability Assessment of GPS Augmentation System Using Geostationary Satellite and QZSS in Seoul Urban Area
- Purification and Characterization of a Novel Heparinase from Bacteroides stercoris HJ-15
- THE ESSENTIAL SPECTRA OF TOEPLITZ OPERATORS WITH SYMBOLS IN H^∞ + C.
- Limited Role of P-Glycoprotein in the Intestinal Absorption of Cyclosporin A(Biopharmacy)
- Thermophysiological Significance and the Role of Local Clothing in Ambient 10℃ Environments
- Downregulation of NF-kB activation in human keratinocytes by melanogenic inhibitors
- Relationship Between Motor Alignment at Postoperative Day 1 and at Year 1 After Symmetric and Asymmetric Surgery in Intermittent Exotropia
- Effect of Oxidation on Electronic and Geometric Properties of Carbon Nanotubes
- Pyroelectric Properties of Lead Antimony Stannate-Lead Titanate-Lead Zirconate Ceramics Modified with La amd Mn
- Ultrastructure of Spermatozoa and Spermiogenesis in Notonecta triguttata (Hemiptera)
- Fabrication of Thermoelectric Sensor Using Silicon-on-Insulator Structure
- Studies on the efficiency of mRNA translation during cold shifts in Tetrahymena
- The prevalence of testicular adrenal rest tumors and associated factors in postpubertal patients with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency
- Positive Toeplitz operators from a harmonic Bergman space into another
- Soybean Nodule-Enhanced CLE Peptides in Roots Act as Signals in GmNARK-Mediated Nodulation Suppression
- Integrated nutrient management for environmental-friendly rice production in salt-affected rice paddy fields of Saemangeum reclaimed land of South Korea
- Compact Toeplitz Operators on the Pluriharmonic Bergman Spaces (Analytic Function Spaces and Their Operators RIMS共同研究報告集)
- An Analytic Approach of the Time Propagator near Nodes in the Quantum Simulation of Electronic Ground States Using One-Dimensional System
- Effects of Carbon Nanotubes on Nematic Backflow in a Twisted Nematic Liquid-Crystal Cell
- An Infinitely Long Monopole Antenna Driven by a Coaxial Cable : Revisited
- Characteristics of Parallel Internal-Type Inductively Coupled Plasmas for Large Area Flat Panel Display Processing
- Conservative Treatment of Intra-Alveolar Root Fracture in the Primary Teeth
- Molecular Structure and Magnetic Properties of Pentapyridyl-based Iron(II) and Cobalt(II) Complexes
- Sesquiterpenes and Other Constituents from Dendranthema zawadskii var. latilobum
- Effect of Channel Length on the Reliability of Amorphous Indium--Gallium--Zinc Oxide Thin Film Transistors
- Plasminogen activator inhibitor-2 (PAI-2) secreted from activated mast cells induces α-smooth muscle actin (α-SMA) expression in dermal fibroblasts
- Off Pump Coronary Artery Bypass versus Mitral Annuloplasty in Moderate Ischemic Mitral Regurgitation
- Visible-Ultraviolet Polarized Reflectivity Spectra of Anisotropically Aligned Single-Walled Carbon Nanotube Films
- Glycosides from the Aerial Parts of Patrinia villosa