Anti-angiogenic and Anti-tumor Activities of 2'-Hydroxy-4'-methoxychalcone(Pharmacology)
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概要
- 論文の詳細を見る
In the present study, we evaluated the in vitro and in vivo anti-angiogenic and anti-tumor activities of 2'-hydroxy-4'-methoxychalcone (HMC). HMC decreased angiogenesis in both chick embryos in the chorioallantoic membrane assay and basic fibroblast growth factor (bFGF)-induced vessel formation in the mouse Matrigel plug assay. This compound also reduced the proliferation of calf pulmonary arterial endothelial cells and was found to possess relatively weak gelatinase/collagenase inhibitory activity in vitro. HMC, when administered subcutaneously at the dose of 30mg/kg for 20 d to mice implanted with murine Lewis lung carcinoma, caused a significant inhibition of tumor volume by 27.2%. Intraperitoneal (i.p.) treatment at the same dosage for 10 d to ICR mice bearing sarcoma 180 caused a significant suppression in tumor weight by 33.7%. Taken together, out data demonstrate that the anti-angiogenic activities of HMC might be due to anti-proliferative activity under inhibition of the induction of COX-2 enzyme. Furthermore, the results suggest that the potent anti-angiogenic activity of HMC seems to be the possible mechanism of action in these animal models of solid tumors.
- 公益社団法人日本薬学会の論文
- 2006-05-01
著者
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Jung Sang
Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institu
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Kim Yeong
Natural Products Research Institute College Of Pharmacy Seoul National University
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Kim Yeong
Natural Products Res. Inst. Coll. Of Pharmacy Seoul National Univ.
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Kim Y
Seoul National Univ. Seoul Kor
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Lim Soon
Dep. Of Food Sci. And Nutrition Hallym Univ.
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Lim Soon
韓国
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Lim Soon
Department Of Food Science And Nutrition Silver Biotechnology Research Center Hallym University
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Lee Yeon
Center For Efficacy Assessment And Dev. Of Functional Foods And Drugs Hallym Univ.
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Jung Sang
Natural Products Res. Center Korea Inst. Of Sci. And Technol. (kist) Gangneung Inst.
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Jung Sang
Natural Products Research Center Korea Institute Of Science And Technology (kist) Gangneung Institut
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Kim-pak Youngmi
Department Of Biochemistry Ulsan University College Of Medicine
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Lim Soon
Department Of Food Science And Nutrition Hallym University:regional Innovation Center Hallym Univers
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SHIN Kuk
Korea Institute of Science and Technology Information
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SHIN Kuk
Natural Products Research Institute, Seoul National University, Republic of Korea
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OHUCHI Kazuo
Laboratory of Pathophysiological Biochemistry Graduate School of Pharmaceutical Sciences, Tohoku Uni
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LIM Soon
Silver Biotechnology Research Center, Hallym University
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LEE Yeon
Silver Biotechnology Research Center, Hallym University
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Jung Sang
韓国
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Ohuchi Kazuo
Faculty Of Pharmacy Yasuda Women's University
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Ohuchi Kazuo
Laboratory Of Pathophysiological Biochemistry Graduate School Of Pharmaceutical Sciences Tohoku Univ
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Lee Yeon
Department Of Food Science And Nutrition Hallym University
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SHIN Kuk
Natural Products Research Institute, Seoul National University
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