Inhibitory Effects of 2'-Hydroxychalcones on Rat Lens Aldose Reductase and Rat Platelet Aggregation
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概要
- 論文の詳細を見る
Inhibitory effects of synthetic 2'-hydroxychalcone derivatives on rat lens aldose reductase (RLAR) and on platelet aggregation were investigated for the prevention or the treatment of chronic diabetic complications. 5'-chloro-4,2'-dihydroxychalcone (8) and 5'-chloro-3,2'-dihydroxychalcone (27) exhbited a potent inhibitory effect on rat platelet aggregation induced by ADP (IC_<50>=0.10 and 0.06 mg/ml, respectively) and collagen (IC_<50>=44 and 16 μg/ml, respectively) but showed relatively weak inhibitory activities on RLAR.
- 公益社団法人日本薬学会の論文
- 2000-11-01
著者
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Jung Sang
Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institu
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Lim Soon
Dep. Of Food Sci. And Nutrition Hallym Univ.
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Lim Soon
韓国
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Lim Soon
Department Of Food Science And Nutrition Silver Biotechnology Research Center Hallym University
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Jung Sang
Natural Products Res. Center Korea Inst. Of Sci. And Technol. (kist) Gangneung Inst.
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Jung Sang
Natural Products Research Center Korea Institute Of Science And Technology (kist) Gangneung Institut
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Lim Soon
Department Of Food Science And Nutrition Hallym University:regional Innovation Center Hallym Univers
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SHIN Kuk
Korea Institute of Science and Technology Information
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LIM Soon
Natural Products Research Institute, Seoul National University, Republic of Korea
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SHIN Kuk
Natural Products Research Institute, Seoul National University, Republic of Korea
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KEUM Sam
Department of New Material Chemistry, Korea University
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JI Jun
Natural Products Research Institute, Seoul National University
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Jung Sang
韓国
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Ji J
Tokyo Inst. Technol. Yokohama Jpn
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Keum Sam
Department Of New Material Chemistry Korea University
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SHIN Kuk
Natural Products Research Institute, Seoul National University
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