Inhibitory Constituents of Aldose Reductase in the Fruiting Body of Phellinus linteus(Pharmacognosy)
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概要
- 論文の詳細を見る
In an effort to characterize active principles for diabetic complication from medicinal mushroom, aldose reductase inhibitors were isolated from the fruiting body of Pliellimis linteus and identified as hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins A (10), and inoscavin A (11), together with protocatechuic acid (1), protocatechualdehyde (2), caffeic acid (3), and ellagic acid (4). Their structures were elucidated by spectroscopic analyses. Among them, davallialactone (7), hypholomine B (9), and ellagic acid (4) exhibited potent rat lens aldose reductase and human recombinant aldose reductase inhibitory activity with IC_<50> values of 0.33, 0.82,0.63 μM and 0.56, 1.28, 1.37 μM, respectively.
- 社団法人日本薬学会の論文
- 2008-04-01
著者
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Lim Soon
Department of Food Science and Nutrition, Hallym University
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Shin Hyun-kyung
Department Of Food Science And Nutrition Hallym University:regional Innovation Center Hallym Univers
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Shin Hyun-kyung
韓国
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Lim Soon
Dep. Of Food Sci. And Nutrition Hallym Univ.
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Lim Soon
韓国
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Lim Soon
Department Of Food Science And Nutrition Silver Biotechnology Research Center Hallym University
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Lee Yeon
Center For Efficacy Assessment And Dev. Of Functional Foods And Drugs Hallym Univ.
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Kang Young-hee
Department Of Food Science And Nutrition Hallym University
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Ban Hyun
Center For Efficacy Assessment And Dev. Of Functional Foods And Drugs Hallym Univ.
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LEE Yeon
Department of Biological Sciences, KAIST
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Lim Soon
Department Of Food Science And Nutrition Hallym University:regional Innovation Center Hallym Univers
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JUNG Ju-Young
College of Veterinary Medicine, Chungnam National University
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KANG Il-Jun
Department of Food Science and Nutrition, Hallym University
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HAN Sang-No
Samsung Pharmaco. Co., Ltd.
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CHUNG Jong-Sang
Biotech Idea Group Co., Ltd.
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Kang Il-jun
Department Of Food Science And Nutrition Hallym University
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Jung Ju-young
College Of Veterinary Medicine Chungnam National University
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Chung Jong-sang
Biotech Idea Group Co. Ltd.
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Han Sang-no
Samsung Pharmaco. Co. Ltd.
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Lee Yeon
Department Of Food Science And Nutrition Hallym University
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Lee Yeon
Department Of Biological Sciences Kaist
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Lim Soon
Department of Food and Nutrition, Hallym University
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Lee Yeon
Department of Applied Plant Science, Chung-Ang University
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Kang Young-Hee
Department of Food and Nutrition, Hallym University
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