Aldose Reductase Inhibitory Compounds from Glycyrrhiza uralensis
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概要
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We evaluated the inhibitory effects of components from the root of Glycyrrhiza uralensis (G. uralensis) on aldose reductase (AR) and sorbitol formation in rat lenses with high levels of glucose as part of our ongoing search of natural sources for therapeutic and preventive agents for diabetic complications. In order to identify the bioactive components of G. uralensis, 5 prenylated flavonoids (semilicoisoflavone B, 7-O-methylluteone, dehydroglyasperin C, dehydroglyasperin D, and isoangustone A), three flavonoids (liquiritigenin, isoliquiritigenin, and licochalcone A), and two triterpenoids (glycyrrhizin and glycyrrhetinic acid) were isolated; their chemical structures were then elucidated on the basis of spectroscopic evidence and comparison with published data. The anti-diabetic complication activities of 10 G. uralensis-derived components were investigated via inhibitory assays using rat lens AR (rAR) and human recombinant AR (rhAR). From the 10 isolated compounds, semilicoisoflavone B showed the most potent inhibition, with the IC50 values of rAR and rhAR at 1.8 and 10.6μM, respectively. In the kinetic analyses using Lineweaver.Burk plots of 1/velocity and 1/concentration of substrate, semilicoisoflavone B showed noncompetitive inhibition against rhAR. The results clearly indicated that the presence of a γ,γ-dimethylchromene ring is partly responsible for the AR inhibitory activity of isoprenoid-type flavonoids. Further, semilicoisoflavone B inhibited sorbitol formation of rat lens incubated with a high concentration of glucose, indicating that this compound may be effective for preventing osmotic stress in hyperglycemia.
著者
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Lee Yeon
Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University
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Kim Seon
Department of Food Science and Nutrition, Hallym University
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Jung Sang
Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institu
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Kim Jin
Institute of Natural Medicine, Hallym University
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Pan Cheol-Ho
Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institu
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Lim Soon
Department of Food Science and Nutrition, Hallym University
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Lee Sang
College Of Industrial Science Chung-ang University
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Kim Jin
Institute For Digestive Research Digestive Disease Center Soon Chun Hyang University College Of Medi
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Lee Sanghyun
Department Of Applied Plant Science Chung-ang University
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Lee Yeon
Center For Efficacy Assessment And Dev. Of Functional Foods And Drugs Hallym Univ.
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Jung Sang
Natural Products Res. Center Korea Inst. Of Sci. And Technol. (kist) Gangneung Inst.
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Pan Cheol-ho
Natural Products Res. Center Korea Inst. Of Sci. And Technol. (kist) Gangneung Inst.
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Lim Soon
Department Of Food Science And Nutrition Hallym University:regional Innovation Center Hallym Univers
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Kim Seon
Department Of Electronic Engineering Chungbuk National University
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Lim Soon
Department of Food and Nutrition, Hallym University
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