Aldose Reductase Inhibitors from the Fruiting Bodies of Ganoderma applanatum(Pharmacognosy)

スポンサーリンク

概要

• 論文の詳細を見る

• The isolation and characterization of rat lens aldose reductase (RLAR) inhibitors from the fruiting bodies of Ganoderma applanatum were conducted. Among the extracts and fractions from G. applanatum tested, the MeOH extract and EtOAc fraction were found to exhibit potent RLAR inhibition in vitro, their IC_<50> being 1.7 and 0.8μg/ml, respectively. From the active EtOAc fraction, seven compounds with diverse structural moieties were isolated and identified as D-mannitol (1), 2-methoxyfatty acids (2), cerebrosides (3), daucosterol (4), 2,5-dihydroxyacetophenone (5), 2,5-dihydroxybenzoic acid (6), and protocatechualdehyde (7). Among them, protocatechualdehyde (7) was found to be the most potent RLAR inhibitor (IC_<50>=0.7μg/ml), and may be useful for the prevention and/or treatment of diabetic complications.

• 公益社団法人日本薬学会の論文
• 2005-06-01

著者

• Kim Ju

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• KANG Sam

  Natural Products Institute, Seoul National University

• SHIM Sang

  Natural Products Research Institute and College of Pharmacy, Seoul National University

• Kim Jin

  韓国

• Lee Sanghyun

  韓国

• Lee Sang

  College Of Industrial Science Chung-ang University

• Son K

  Department Food & Nutriton Andong National University

• Shim Sang

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• Son Jong

  Coll. Of Pharmacy Yeungnam Univ.

• Lee Sanghyun

  Department Of Applied Plant Science Chung-ang University

• Kang Sam

  韓国

• Kang Sam

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• Kang Sam

  Natural Product Research Institute Seoul National University

• LEE Sanghyun

  Natural Products Research Institute, Seoul National University, Republic of Korea

• SHIN Kuk

  Natural Products Research Institute, Seoul National University, Republic of Korea

• Kang S

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• Kim Ju

  Natural Products Res. Inst. And Coll. Of Pharmacy Seoul National Univ.

• Lee Sanghyun

  Natural Products Research Institute And College Of Pharmacy Seoul National University

• SHIN Kuk

  Natural Products Research Institute, Seoul National University

関連論文

• Effect of Dexamethasone on STAT6-Dependent Ym1/2 Expression in Vivo and in Vitro(Biochemistry)
• Hepatotoxicity and Immunotoxicity of 1-Bromohexane and Its Glutathione Conjugation in Female BALB/c Mice
• Aldose Reductase Inhibitory Compounds from Glycyrrhiza uralensis
• Anti-inflammatory Activity of Pectolinarigenin and Pectolinarin Isolated from Cirsium chanroenicum(Pharmacology)
• Protective Effect of Baicalin Against Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice
• Ochnaflavone, Naturally Occurring Biflavonoid, Inhibits Phospholipase A_2 Dependent Phosphatidylethanolamine Degradation in a CCl_4-Induced Rat Liver Microsome(Biochemistry)
• Effects of Anti-inflammatory Biflavonoid, Ginkgetin, on Chronic Skin Inflammation(Pharmacology)
• Anti-inflammatory Activity of Ailanthus altissima in Ovalbumin-Induced Lung Inflammation(Biochemistry)
• Anti-asthmatic Activity of an Ethanol Extract from Saururus chinensis(Biochemistry)
• Ginkgetin, a Biflavone from Ginko biloba Leaves, Inhibits Cyclooxygenases-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells(Biochemistry)
• Saponins and Other Constituents from the Leaves of Aralia elata
• Antiinflammatory Activity of Astilbic Acid from Astilbe chinensis(Biochemistry/Molecular Biology)
• Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms
• Triterpenoid Saponins from the Roots of Sophora koreensis
• Phenolic Glycosides from Pyrola japonica
• Inhibitory Effects of Nardostachin on Nitric Oxide, Prostaglandin E_2, and Tumor Necrosis Factor-α Production in Lipopolysaccharid Activated Macrophages(Biochemistry/Molecular Biology)
• Tyrosinase Inhibitory Prenylated Flavonoids from Sophora flavescens(Pharmacology)
• Dual Inhibition of Cyclooxygenases-2 and 5-Lipoxygenase by Deoxypodophyllotoxin in Mouse Bone Marrow-Derived Mast Cells(Biochemistry/Molecular Biology)
• Inhibition of Nitric Oxide and Tumor Necrosis Factor-α (TNF-α) Production by Propenone Compound through Blockade of Nuclear Factor (NF)-κB Activation in Cultured Murine Macrophages (Biochemistry/Molecular Biology)
• Papyriflavonol A from Broussonetia papyrifera Inhibits the Passive Cutaneous Anaphylaxis Reaction and Has a Secretory Phospholipase A_2-Inhibitory Activity
• Asterosaponins Isolated from the Starfish Asterias amurensis
• Inhibition of Aldose Reductase by Phenylethanoid Glycoside Isolated from the Seeds of Paulownia coreana
• Protective Effect of (4-Methoxybenzylidene)-(3-methoxynophenyl)amine against Neuronal Cell Death Induced by Oxygen and Glucose Deprivation in Rat Organotypic Hippocampal Slice Culture(Medicinal Chemistry)
• Identification of a New Cytotoxic Biflavanone from Selaginella doederleinii
• Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production
• Growth Inhibition and Induction of G1 Phase Cell Cycle Arrest in Human Lung Cancer Cells by a Phenylbutenoid Dimer Isolated from Zingiber cassumunar(Pharmacology)
• Cyclooxygenase-2 Inhibitory Phenylbutenoids from the Rhizomes of Zingiber cassumunar
• Humulene Derivatives from Zingiber zerumbet with the Inhibitory Effects on Lipopolysaccharide-Induced Nitric Oxide Production
• Flavonols Inhibit Sortases and Sortase-Mediated Staphylococcus aureus Clumping to Fibrinogen(Pharmacology)
• Protein Glycation Inhibitors from the Fruiting Body of Phellinus linteus(Pharmacognosy)
• Inhibitory Effects of Isorhamnetin-3-O-β-D-glucoside from Salicornia herbacea on Rat Lens Aldose Reductase and Sorbitol Accumulation in Streptozotocin-Induced Diabetic Rat Tissues(Pharmacognosy)
• The mechanism of anti-inflammatory activity of 2'-hydroxychalcone derivatives
• Preventive Effect of 7,8-Dihydroxyflavone against Oxidative Stress Induced Genotoxicity(Biochemistry)
• Cytoprotective Effects of KIOM-79 on Streptozotocin Induced Cell Damage by Inhibiting ERK and AP-1(Highlighted paper selected by Editor-in-chief,Biochemistry)
• Caffeic Acid Protects Hydrogen Peroxide Induced Cell Damage in WI-38 Human Lung Fibroblast Cells(Molecular and Cell Biology)
• Protective Effect of Puerariae Radix on Oxidative Stress Induced by Hydrogen Peroxide and Streptozotocin(Molecular and Cell Biology)
• Antioxidant Activity of Jionoside D from Clerodendron trichotomum(Biochemistry/Molecular Biology)
• Iridoid Esters from Patrinia saniculaefolia
• Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Benz[f]indole-4,9-dione Analogs(Biochemistry & Molecular Biology)
• Two New Cycloartane Saponins from the Roots of Astragalus membranaceus
• Pharmacologically Active Saikosaponin in Bupleurum falcatum Detected by Competitive ELISA and Eastern Blotting Using Monoclonal Antibodies(Crop Physiology & Ecology)
• Eastern blotting and use of anti-saikosaponin a monoclonal antibodies for detection of saikosaponins
• Daphnane Diterpene Esters with Anti-proliferative Activities against Human Lung Cancer Cells from Daphne genkwa
• Activity-Guided Isolation of Saponins from Kalopanaxpictus with Anti-inflammatory Activity
• Metabolism of FPP-3, an Anti-inflammatory Propenone Compound, in Rat by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry(Biopharmacy)
• Determination of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound, by high performance liquid chromatography with ultraviolet spectrometry
• The Effect of 1-Furan-2-yl-3-pyridine-2-yl-propenone on Pharmacokinetic Parameters of Theophylline(Biopharmacy)
• Anti-complementary Activity of Ursane-Type Triterpenoids from Weigela subsessilis(Pharmacognosy)
• Xanthorrhizol, a Natural Sesquiterpenoid, Induces Apoptosis and Growth Arrest in HCT116 Human Colon Cancer Cells
• Triterpenoid Saponins from the Seeds of Pharbitis nil
• Aldose Reductase Inhibitors from the Fruiting Bodies of Ganoderma applanatum(Pharmacognosy)
• Norditerpenoid Alkaloids from the Processed Tubers of Aconitum carmichaeli
• Geniposide from Gardenia jasminoides Attenuates Neuronal Cell Death in Oxygen and Glucose Deprivation-Exposed Rat Hippocampal Slice Culture(Pharmacognosy)
• A New Acylated Triterpene from the Roots of Chaenomeles japonica
• Synthesis and PPAR-γ Ligand-Binding Activity of the New Series of 2'-Hydroxychalcone and Thiazolidinedione Derivatives
• Inhibitory Effects of Ethaverine, a Homologue of Papaverine, on Monoamine Oxidase Activity in Mouse Brain
• Anti-angiogenic and Anti-tumor Activities of 2'-Hydroxy-4'-methoxychalcone(Pharmacology)
• Loniceroside C, an Antiinflammatory Saponin from Lonicera japonica
• Anti-apoptotic and Hepatoprotective Effects of Gomisin A on Fulminant Hepatic Failure Induced by D-Galactosamine and Lipopolysaccharide in Mice
• Anti-obesity Effect of Dioscorea nipponica Makino with Lipase-inhibitory Activity in Rodents(Food & Nutrition Science)
• Cyclooxygenase-2 Inhibitory Cerebrosides from Phytolaccae Radix
• Inhibitory Effects of 2'-Hydroxychalcones on Rat Lens Aldose Reductase and Rat Platelet Aggregation
• Biflavone Glucosides from Ginkgo biloba Yellow Leaves
• Nuclear Factor E2–Related Factor 2–Mediated Induction of NAD(P)H:Quinone Oxidoreductase 1 by 3,5-Dimethoxy-trans-stilbene
• Protective Mechanism of Glycyrrhizin on Acute Liver Injury Induced by Carbon Tetrachloride in Mice(Pharmacology)
• Anti-obesity Effect of Pinellia ternata Extract in Zucker Rats(Pharmacognosy)
• Phenolic Glycosides from the Stem Bark of Albizzia julibrissin
• Araloside A, an Antiulcer Constituent from the Root Bark of Aralia elata(Pharmacology)
• Testosterone 5α-Reductase Inhibitors, Menaquinone 7 Produced by a Bacillus and Phenazine Methosulfate
• A New 2-Arylbenzofuran with Antioxidant Activity from the Black Colored Rice (Oryza sativa L.) Bran
• Comparative Molecular Field Analysis Study of Stilbene Derivatives Active against A549 Lung Carcinoma
• Antioxidative and Hypolipidemic Effects of Diosgenin, a Steroidal Saponin of Yam (Dioscorea spp.), on High-Cholesterol Fed Rats
• Two New Acylated Flavonol Glycosides from Vicia amurensis
• A New Polyoxygenated Triterpene and Two New Aeginetic Acid Quinovosides from the Roots of Rehmannia glutinosa
• PC24 SAPONINS AND FLAVONOID GLYCOSIDES FROM YELLOW SWEETCLOVER
• Hepatoprotective Effect of Pinoresinol on Carbon Tetrachloride-Induced Hepatic Damage in Mice
• Plasma Deposition of HfO_2 and TiO_2 onto Plasma-Nitrided Ge Surfaces
• Effect of F1ying Time and Aircraft Types on the Hearing of Korean Air Force Pilots (日本人間工学会第43回講演集) -- (The Joint Symposium on Ergonomics(JES/ESK))
• INHIBITION BY HYDROXYUREA OF THE REBOUND OF GRANULOMATOUS INFLAMMATION FOLLOWING WITHDRAWAL OF GLUCOCORTICOID THERAPY
• Alleviation of OVA-Induced Airway Inflammation by Flowers of Inula japonica in a Murine Model of Asthma
• Jumping of a droplet on a superhydrophobic surface in AC electrowetting
• Sesquiterpenes and Other Constituents from Dendranthema zawadskii var. latilobum
• Glycosides from the Aerial Parts of Patrinia villosa

もっと見る 閉じる

スポンサーリンク