Nuclear Factor E2–Related Factor 2–Mediated Induction of NAD(P)H:Quinone Oxidoreductase 1 by 3,5-Dimethoxy-trans-stilbene
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概要
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NAD(P)H:quinone oxidoreductase 1 (NQO1), a phase II enzyme, plays an important role in the detoxification or chemoprotection of carcinogens, and induction of this enzyme is a target for the prevention of carcinogenesis. Natural stilbenoids have potential cancer chemopreventive activities, potentially through affecting NQO1 activity. Along this line, several stilbenoids were evaluated to procure more potent compounds for inducing NQO1 activity in cultured murine Hepa 1c1c7 cells. As a result, we found that 3,5-dimethoxy-trans-stilbene (DMS) possesses potent NQO1 induction activity through up-regulation of both protein and mRNA expression of NQO1 as determined by Western blot and reverse transcription–polymerase chain reaction analysis, respectively. DMS also increased protein expression of heme oxygenase-1 (HO-1), another phase II enzyme. This induction of NQO1 and HO-1 by DMS was closely related to the regulation of nuclear factor E2–related factor 2 (Nrf2). The translocation and activation of Nrf2 by DMS was also involved in the modulation of the upstream signal transduction molecule, protein kinase C δ. These findings suggest that DMS might have a cancer chemopreventive activity by inducing detoxifying enzymes such as NQO1 and HO-1.
著者
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Lee Sang
College Of Industrial Science Chung-ang University
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MIN Hye-Young
College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans Univers
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CHUNG Hwa-Jin
College of Pharmacy, Ewha Womans University
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PARK Eun-Jung
College of Pharmacy, Ewha Womans University
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PARK Hyen
College of Pharmacy, Ewha Womans University
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Park Hyen
College Of Pharmacy Ewha Womans University
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Chung Hwa-jin
College Of Pharmacy Ewha Womans University:center For Cell Signaling & Drug Discovery Research E
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Park Eun-jung
College Of Pharmacy Ewha Womans University:center For Cell Signaling & Drug Discovery Research E
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Lee Sang
College Of Agriculture And Life Sciences Kyungpook National University
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Ahn Yong-Hyun
College of Natural Sciences, Dankook University, Korea
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Pyee Jae-Ho
College of Natural Sciences, Dankook University, Korea
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Park Eun-jung
College Of Pharmacy Dongduk Women's University
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Ahn Yong-hyun
College Of Natural Sciences Dankook University
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Min Hye-young
College Of Pharmacy Ewha Womans University
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