Humulene Derivatives from Zingiber zerumbet with the Inhibitory Effects on Lipopolysaccharide-Induced Nitric Oxide Production

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概要

• 論文の詳細を見る

• A new humulene sesquiterpene, 5-hydroxyzerumbone (5-hydroxy-2E,6E,9E-humulatrien-8-one) (1) and a known compound, zerumboneoxide (2) were isolated from the rhizomes of Zingiber zerumbet (Zingiberaceae), and found to inhibit lipopolysaccharide-induced nitric oxide production in murine macrophage RAW 264.7 cells with IC_<50> values of 14.1 and 23.5μM, respectively, by bioassay-guided fractionation (positive control: N^ω-monomethyl-L-arginine, IC_<50>=21.3μM). The structure of 1 was determined by spectroscopic methods including 1D and 2D-NMR.

• 社団法人日本薬学会の論文
• 2005-07-01

著者

• KANG Sam

  Natural Products Institute, Seoul National University

• Lee Sang

  College Of Industrial Science Chung-ang University

• JANG Dae

  Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine

• Kim Moon

  College Of Pharmacy Ewha Womans University

• Han Ah-reum

  韓国

• Han Ah-reum

  College Of Pharmacy And Center For Cell Signaling & Drug Discovery Research Ewha Womans Universi

• Lee Sang

  Coll. Of Pharmacy Ewha Womans Univ.

• MIN Hye-Young

  College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans Univers

• HAN Ah

  College of Pharmacy, Ewha Womans University

• SEO Eun

  College of Pharmacy, Ewha Womans University

• JANG Dae

  Division of Molecular Life Sciences, Ewha Womans University

• MIN Hye

  College of Pharmacy, Ewha Womans University

• WINDONO Tri

  Faculty of Pharmacy, University of Surabaya

• JEOHN Gwang

  Faculty of Science, Brawijaya University

• Jang Dae

  Diabetes Res. Center Div. Of Traditional Korean Medicine (tkm) Integrated Res. Korea Inst. Of Orient

• Jang Dae

  Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins

• Jang Dae

  Department Of Herbal Pharmaceutical Development Korea Institute Of Oriental Medicine

• Kang Sam

  Natural Product Research Institute Seoul National University

• Min Hye

  College Of Pharmacy And The Center For Cell Signaling & Drug Discovery Research Ewha Womans Univ

• Windono Tri

  Faculty Of Pharmacy University Of Surabaya

• Jeohn Gwang

  Faculty Of Science Brawijaya University

• Seo Eun-kyoung

  Natural Product Chemistry Laboratory College Of Pharmacy And The Center For Cell Signaling & Dru

• Han Ah

  College Of Pharmacy And The Center For Cell Signaling & Drug Discovery Research Ewha Womans Univ

• Seo Eun

  Natural Product Chemistry Laboratory College Of Pharmacy & The Center For Cell Signaling And Dru

• Lee Sang

  College Of Agriculture And Life Sciences Kyungpook National University

• Seo Eun

  College Of Pharmacy And The Center For Cell Signaling & Drug Discovery Research Ewha Womans Univ

• Han Ah-reum

  Dep. Of Physiology Coll. Of Oriental Medicine Kyung Hee Univ.

• Kim Moon-Sun

  College of Pharmacy, Ewha Womans University

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