Daphnane Diterpene Esters with Anti-proliferative Activities against Human Lung Cancer Cells from Daphne genkwa
スポンサーリンク
概要
- 論文の詳細を見る
Two new daphnane-type diterpene esters, yuanhuahine (1) and yuanhualine (2), were isolated from the flowers of Daphne genkwa (Thymelaeaceae) along with three known diterpene esters, yuanhuacine (3), yuanhuadine (4), and yuanhuagine (5). Their structures were determined by a combination of 1D and 2D NMR experiments, including correlation spectroscopy (COSY), heteronuclear multiple quantum correlation (HMQC), heteronuclear multiple bond correlation (HMBC), and rotating frame Overhauser enhancement spectroscopy (ROESY) sequences, and mass spectrometry. All the isolated compounds were tested against A549 human lung cancer cells and MRC-5 human normal lung epithelial cells. Compounds 1—5 exhibited potent anti-proliferative effects against A549 lung cancer cells with IC50 values of 12—53 nM, whereas these compounds were relatively non-cytotoxic against MRC-5 normal lung epithelial cells.
- 社団法人 日本薬学会の論文
著者
-
Lee Sang
College Of Industrial Science Chung-ang University
-
NAM Joo-Won
College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans Univers
-
SEO Eun-Kyoung
College of Pharmacy and The Center for Cell Signaling & Drug Discovery Research, Ewha Womans Univers
-
HONG Ji-Young
College of Pharmacy, Ewha Womans University
-
Nam Joo-won
Coll. Of Pharmacy Ewha Womans Univ.
-
Seo Eun-kyoung
Natural Product Chemistry Laboratory College Of Pharmacy And The Center For Cell Signaling & Dru
-
Lee Sang
College Of Agriculture And Life Sciences Kyungpook National University
-
Nam Joo-Won
College of Pharmacy, Ewha Womans University
-
Seo Eun-Kyoung
College of Pharmacy, Ewha Womans University
-
Lee Sang
College of Pharmacy, Ewha Womans University
関連論文
- Two New Stereoisomers of Neolignan and Lignan from the Flower Buds of Magnolia fargesii
- Hepatotoxicity and Immunotoxicity of 1-Bromohexane and Its Glutathione Conjugation in Female BALB/c Mice
- Aldose Reductase Inhibitory Compounds from Glycyrrhiza uralensis
- Inhibition of Aldose Reductase by Phenylethanoid Glycoside Isolated from the Seeds of Paulownia coreana
- Protective Effect of (4-Methoxybenzylidene)-(3-methoxynophenyl)amine against Neuronal Cell Death Induced by Oxygen and Glucose Deprivation in Rat Organotypic Hippocampal Slice Culture(Medicinal Chemistry)
- Identification of a New Cytotoxic Biflavanone from Selaginella doederleinii
- Identification of a New Naphthalene and Its Derivatives from the Bulb of Eleutherine americana with Inhibitory Activity on Lipopolysaccharide-Induced Nitric Oxide Production
- Inhibition of LPS-Induced iNOS, COX-2 and Cytokines Expression by Poncirin through the NF-κB Inactivation in RAW 264.7 Macrophage Cells(Pharmacognosy)
- Growth Inhibition and Induction of G1 Phase Cell Cycle Arrest in Human Lung Cancer Cells by a Phenylbutenoid Dimer Isolated from Zingiber cassumunar(Pharmacology)
- A New Flavanone Glycoside from the Dried Immature Fruits of Poncirus trifoliata
- Cyclooxygenase-2 Inhibitory Phenylbutenoids from the Rhizomes of Zingiber cassumunar
- Humulene Derivatives from Zingiber zerumbet with the Inhibitory Effects on Lipopolysaccharide-Induced Nitric Oxide Production
- Protein Glycation Inhibitors from the Fruiting Body of Phellinus linteus(Pharmacognosy)
- Inhibitory Effects of Isorhamnetin-3-O-β-D-glucoside from Salicornia herbacea on Rat Lens Aldose Reductase and Sorbitol Accumulation in Streptozotocin-Induced Diabetic Rat Tissues(Pharmacognosy)
- The mechanism of anti-inflammatory activity of 2'-hydroxychalcone derivatives
- Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Benz[f]indole-4,9-dione Analogs(Biochemistry & Molecular Biology)
- Pharmacologically Active Saikosaponin in Bupleurum falcatum Detected by Competitive ELISA and Eastern Blotting Using Monoclonal Antibodies(Crop Physiology & Ecology)
- Eastern blotting and use of anti-saikosaponin a monoclonal antibodies for detection of saikosaponins
- Daphnane Diterpene Esters with Anti-proliferative Activities against Human Lung Cancer Cells from Daphne genkwa
- Two New Stereoisomers of Tetrahydrofuranoid Lignans from the Flower Buds of Magnolia fargesii
- Metabolism of FPP-3, an Anti-inflammatory Propenone Compound, in Rat by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry(Biopharmacy)
- Determination of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound, by high performance liquid chromatography with ultraviolet spectrometry
- The Effect of 1-Furan-2-yl-3-pyridine-2-yl-propenone on Pharmacokinetic Parameters of Theophylline(Biopharmacy)
- Xanthorrhizol, a Natural Sesquiterpenoid, Induces Apoptosis and Growth Arrest in HCT116 Human Colon Cancer Cells
- Aldose Reductase Inhibitors from the Fruiting Bodies of Ganoderma applanatum(Pharmacognosy)
- Geniposide from Gardenia jasminoides Attenuates Neuronal Cell Death in Oxygen and Glucose Deprivation-Exposed Rat Hippocampal Slice Culture(Pharmacognosy)
- Inhibitory Effects of Ethaverine, a Homologue of Papaverine, on Monoamine Oxidase Activity in Mouse Brain
- Nuclear Factor E2–Related Factor 2–Mediated Induction of NAD(P)H:Quinone Oxidoreductase 1 by 3,5-Dimethoxy-trans-stilbene
- Testosterone 5α-Reductase Inhibitors, Menaquinone 7 Produced by a Bacillus and Phenazine Methosulfate
- Comparative Molecular Field Analysis Study of Stilbene Derivatives Active against A549 Lung Carcinoma
- Asperlin From the Marine-Derived Fungus Aspergillus sp. SF-5044 Exerts Anti-inflammatory Effects Through Heme Oxygenase-1 Expression in Murine Macrophages
- Identification of a Tryptanthrin Metabolite in Rat Liver Microsomes by Liquid Chromatography/Electrospray Ionization-Tandem Mass Spectrometry(Biopharmacy)
- Nuclear Factor E2-Related Factor 2-Mediated Induction of NAD(P)H : Quinone Oxidoreductase 1 by 3,5-Dimethoxy-trans-stilbene
- Asperlin From the Marine-Derived Fungus Aspergillus sp. SF-5044 Exerts Anti-inflammatory Effects Through Heme Oxygenase-1 Expression in Murine Macrophages
- Diversity and community structure of ectomycorrhizal fungi in Pinus thunbergii coastal forests in the eastern region of Korea
- Ectomycorrhizal fungal community associated with naturally regenerating Pinus densiflora Sieb. et Zucc. seedlings on exposed granite slopes along woodland paths
- Nucleophilic Activation of a Tetra-Substituted Mitomycin Cyclic Bis-Disulfide
- Improved Skin Delivery of Voriconazole with a Nanostructured Lipid Carrier-Based Hydrogel Formulation