Two New Stereoisomers of Tetrahydrofuranoid Lignans from the Flower Buds of Magnolia fargesii

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概要

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• Two new stereoisomers of tetrahydrofuranoid lignans, 7S,8R,7'S,8'R- (1) and 7R,8S,7'S,8'R-3,4,3',4'-tetramethoxy-9,7'-dihydroxy-8.8',7.O.9'-lignan (2) along with nine known lignans including tetrahydrofuranoids (3, 4) and tetrahydrofurofuranoids (5-11) were isolated from a CHCl_3-soluble fraction of the flower buds of Magnoliafargesii Two tetrahydrofuranoids, magnostellin A (3) and lariciresinol dimethyl ether (4) were isolated from this species for the first time. The structures of these compounds (1-11) were identified by spectroscopic methods as well as by comparison with published values. Absolute configurations of new stereoisomers (1, 2) were determined by the Mosher's esterification method and Circular Dichroism (CD) studies. All the isolates (1-11) were evaluated for their antioxidant activities using modified superoxide radical-scavenging assay. Compounds 5-8 showed the potent superoxide radical-scavenging activities with the ED_<50> values of 19.2, 19.2, 16.5, and 27.7μM, respectively, as compared with standard antioxidants (BHA: 22.8μM; Trolox: 940μM).

• 公益社団法人日本薬学会の論文
• 2007-01-01

著者

• JANG Dae

  Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine

• SEO Eun-Kyoung

  Natural Product Chemistry Laboratory, College of Pharmacy & The Center for Cell Signaling and Drug D

• NAM Joo-Won

  Natural Product Chemistry Laboratory, College of Pharmacy & The Center for Cell Signaling and Drug D

• YANG Min

  Division of Applied Life Science, Gyeongsang National University

• Yang Min

  Division Of Applied Life Science Gyeongsang National University

• Kim J‐y

  Yeungnam Univ. Taegu Kor

• KIM Jong-Pyung

  Laboratory of Antioxidants, Korea Research Institute of Bioscience and Biotechnology

• Lee Jun

  Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins

• Kim Jin

  Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins

• Jang Dae

  Diabetes Res. Center Div. Of Traditional Korean Medicine (tkm) Integrated Res. Korea Inst. Of Orient

• Jang Dae

  Diabetes Research Center Division Of Traditional Korean Medicine (tkm) Integrated Research Korea Ins

• Jang Dae

  Department Of Herbal Pharmaceutical Development Korea Institute Of Oriental Medicine

• Kim Jong-bin

  Coll. Of Pharmacy Kyung-hee Univ.

• Kim Jong-pyung

  Laboratory Of Antioxidants Korea Research Institute Of Bioscience And Biotechnology

• Kim Joo-hwan

  Dep. Of Life Sci. Daejeon Univ.

• PARK Ki

  Division of Plant Environment, National Yeongnam Agricultural Experiment Station, RDA

• Park Ki

  Division Of Biological Sciences Pusan National University

• LEE Dongho

  Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University

• Kim Jin

  Diabetic Complications Res. Center Div. Of Traditional Korean Medicine Integrated Res. Korea Inst. O

• Nam Joo-won

  Coll. Of Pharmacy Ewha Womans Univ.

• Seo Eun-kyoung

  Natural Product Chemistry Laboratory College Of Pharmacy And The Center For Cell Signaling & Dru

• LEE Jun

  Natural Product Chemistry Laboratory, College of Pharmacy and The Center for Cell Signaling & Drug D

• Lee Jun

  韓国

• Seo Eun

  Natural Product Chemistry Laboratory College Of Pharmacy & The Center For Cell Signaling And Dru

• Lee Dongho

  Division Of Biotechnology College Of Life Sciences And Biotechnology Korea University

• Lee Jong-won

  College Of Pharmacy Ewha Womans University

• Yang Min

  Division Of Applied Life Science (bk21 Program) Department Of Agricultural Chemistry Gyeongsang Nati

• Park Ki

  Division Of Applied Life Science (bk21 Program) Eb-ncrc Institute Of Agriculture & Life Science

• Park Ki

  Division Of Applied Life Science Gyeongsang National University

• Park Ki

  Division Of Applied Life Science (bk21 Program Ials) Gyeongsang National University

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