Delphinidin Ameliorates Beta-Amyloid-Induced Neurotoxicity by Inhibiting Calcium Influx and Tau Hyperphosphorylation

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概要

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• Beta-amyloid (Aβ) has been suggested to induce neurotoxicity in Alzheimer’s disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against Aβ-induced toxicity. Aβ (25–35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from Aβ by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against Aβ-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.

• 社団法人 日本農芸化学会の論文

著者

• Park So-young

  Environmental Toxico-genomic & Proteomic Center College Of Medicine Korea University

• Hwang Kwang

  Department Of Immunology College Of Pharmacy Chung-ang University

• LEE Dongho

  Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University

• Kim Hyo-Shin

  Department of Immunology, College of Pharmacy, Research Institute for Translational System Biomics,

• Sul Donggeun

  Environmental Toxico-Genomic and Proteomic Center, College of Medicine

• Lim Ji-Youn

  Environmental Toxico-Genomic and Proteomic Center, College of Medicine

• JOO Seong

  Research Institute of Veterinary Medicine, Chungbuk University

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