Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production

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概要

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• Two new melampolide-type sesquiterpene lactones, 8β-epoxyangeloyloxy-9α-ethoxy-14-oxo-acanthospermolide (1) and 8β-angeloyloxy-9α-ethoxy-14-oxo-acanthospermolide (2), were isolated from the leaves of yacon [Smallanthus sonchifolia (POEPP. et ENDL.) H. Robinson] along with eleven known melampolides, allo-schkuhriolide (3), enhydrin (4), polymatin A (5), fluctuanin (6), 8β-angeloyloxy-9α-acetoxy-14-oxo-acanthospermolide (7), 8β-angeloyloxy-14-oxo-acanthospermolide (8), 8β-methacryloyloxymelampolid-14-oic acid methyl ester (9), uvedalin (10), polymatin B (11), 8β-tigloyloxymelampolid-14-oic acid methyl ester (12), and sonchifolin (13). Their structures were established on the basis of spectroscopic evidence including 1D- and 2D-NMR experiments. All isolates were evaluated for inhibition of LPS-induced nitric oxide production in murine macrophage RAW 264.7 cells.

• 社団法人日本薬学会の論文
• 2008-02-01

著者

• Hong Seong

  College Of Pharmacy Chungbuk National University:division Of Biotechnology College Of Life Sciences

• Hong S

  Chungbuk National Univ. Cheongju Kor

• Oh Ki-wan

  College Of Pharmacy Chunghuk National University

• PARK Jeong

  College of Pharmacy, Seoul National University

• Lee M

  College Of Pharmacy Chungbuk National University

• Park Jeong

  College Of Pharmacy And Research Institute Of Pharmaceutical Sciences Seoul National University

• Lee Seon

  College Of Pharmacy Chungbuk National University

• Hwang Bang

  College Of Pharmacy Chungbuk National University

• Oh Ki-wan

  College Of Pharmacy Chungbuk National University

• HAN Xiang

  College of Pharmacy, Chungbuk National University

• LEE Min

  College of Pharmacy, Chungbuk National University

• HWANG Ji

  College of Pharmacy, Chungbuk National University

• HAN Kun

  College of Pharmacy, Chungbuk National University

• LEE Myung

  College of Pharmacy, Chungbuk National University

• LEE Heesoon

  College of Pharmacy, Chungbuk National University

• KIM Wook

  Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University

• LEE Dongho

  Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University

• Lee M

  Chungbuk National Univ. Chungbuk Kor

• Han Xiang

  College Of Pharmacy Chungbuk National University

• Lee Myung

  College Of Pharmacy Chungbuk National University

• Hwang Ji

  College Of Pharmacy Chungbuk National University

• Lee Dongho

  Division Of Biotechnology College Of Life Sciences And Biotechnology Korea University

• Lee Dongho

  Anticancer Research Laboratory Korea Research Institute Of Bioscience And Biotechnology

• Hwang Bang

  Coll. Of Pharmacy Chungbuk National Univ.

• Han Kun

  College Of Pharmacy Chungbuk National University

• Han Xiang

  College Of Natural Resources And Life Science Bk21 Center For Silver-bio Industrialization Dong-a Un

• Lee Heesoon

  College Of Pharmacy Chungbuk National University

• Lee Myung

  College Of Pharmacy And Research Center For Bioresource And Health Chungbuk National University

• Lee Min

  College Of Pharmacy Chungbuk National University

• Park Jeong

  College Of Pharmacy Chungbuk National University

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