Hirsutenone Directly Blocks Human ether-a-go-go Related Gene K+ Channels
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概要
- 論文の詳細を見る
The aim of the present study was to investigate whether hirsutenone affects the human ether-a-go-go related gene (hERG) K+ channels. Many drugs promote formation of the acquired form of long QT syndrome (LQTS) by blocking the hERG K+ channels. Hirsutenone, a new candidate for the treatment inflammatory skin lesions, induced a concentration-dependent decrease in hERG K+ current amplitudes. Hirsutenone significantly decreased the time constants at the onset of inactivation. However, the reductions in the time constants of steady-state inactivation and the recovery from inactivation after hirsutenone treatment were not significant. In addition, the drug had no effect on the voltage-dependent activation curve or the steady-state inactivation curve. In summary, hirsutenone potentially acts as a blocker of hERG K+ channels functioning by modifying the channel inactivation kinetics.
- 公益社団法人 日本薬学会の論文
著者
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Seo Seong
Department of Dermatology, College of Medicine, Chung-Ang University
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Seo Seong
Department Of Dermatology College Of Medicine Chung-ang University
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Choi Sun
College of Pharmacy, Chung Ang University
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Choi Young
College Of Pharmacy Seoul National University
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Ko Jae-hong
Department Of Physiology College Of Medicine Chung-ang University
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Lee Min
College Of Pharmacy Chungbuk National University
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Lee Chung
Department Of Anesthesiology And Pain Medicine Asan Medical Center University Of Ulsan College Of Me
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Bang Hyoweon
Department of Physiology, College of Medicine, Chung-Ang University
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YUN Jihyun
Department of Physiology, College of Medicine, Chung-Ang University
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BAE Hyemi
Department of Physiology, College of Medicine, Chung-Ang University
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Kim Jung-Ha
Department of Family Medicine, College of Medicine, Chung-Ang University
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Lim Inja
Department of Physiology, College of Medicine, Chung-Ang University
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Lee Min
College of Pharmacy, Chung-Ang University
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Choi Sun
College of Pharmacy, Chung-Ang University
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Lee Chung
Department of Pharmacology, College of Medicine, Chung-Ang University
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