Polyacetylenes from Angelica gigas and Their Inhibitory Activity on Nitric Oxide Synthesis in Activated Macrophages
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概要
- 論文の詳細を見る
In activated macrophages the inducible form of nitric oxide synthase (i-NOS) generates high amounts of the toxic mediator, nitric oxide (NO) which contributes to the circulatory failure associated with septic shock. Two polyacetylenes were isolated from the medicinal plant Angelica gigas and their structures were elucidated as octadeca-1,9-dien-4,6-diyn-3,8,18-triol (1) and 18-acetoxy-octadeca-1,9-dien-4,6-diyn-3,8-diol (2) by spectroscopic method. These polyacetylenes and their peracetate, 3,8,18-triacetoxy-octadeca-1,9-dien-4,6-diyn (3) inhibited the production of NO in LPS-activated RAW 264.7 cells by suppressing the i-NOS enzyme expression. These new inhibitors of i-NOS expression may have potential in the treatment of endotoxemia and inflammation accompanied by the overproduction of NO.
- 公益社団法人日本薬学会の論文
- 2000-07-01
著者
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Choi Young
College of Pharmacy, Chung-Ang University
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Ryu Jae-ha
Coll. Of Pharmacy Sookmyung Women's Univ.
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Ryu J‐h
Sookmyung Women's Univ. Soeul Kor
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AHN Hanna
College of Pharmacy, Sookmyung Women's University
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RYU Jae-Ha
College of Pharmacy, Sookmyung Women's University
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Choi Young
College Of Pharmacy Seoul National University
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Ryu Jae-ha
College Of Pharmacy Sookmyung Women's University
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Ahn Hanna
College Of Pharmacy Sookmyung Women's University
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Choi Young
College Of Pharmacy Sookmyung Women's University
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