Neuroprotective and Antioxidant Effects of the Ethyl Acetate Fraction Prepared from Tussilago farfara L.(Pharmacology)
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概要
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The flower buds of Tussilago farfara L. (Compositae) have been traditionally used in Oriental medicine for the treatment of bronchitis and asthma. The extract of T. farfara was reported to exhibit antiinflammatory actions by inhibiting arachidonic acid metabolism and nitric oxide (NO) production in lipopolysaccharide-activated macrophages. In the present study, we investigated the effects of the ethyl acetate (EA) fraction on various types of neuronal cell damage induced in primary cultured rat cortical cells. Its antioxidant activities were also evaluated by cell-free bioassays. We found that the EA fraction potently inhibited the neuronal damage induced by arachidonic acid. We also found that it significantly attenuated the neuronal damage induced by spermine NONOate, a stable NO generator. In addition, it inhibited the A_<β(25-35)>-induced neurotoxicity and glutamate- or N-methyl-D-aspartic acid-induced excitotoxicity. It was found that the oxidative neuronal damage induced by H_2O_2, xanthine/xanthine oxidase, or Fe^<2+>/ascorbic acid was also inhibited by the EA fraction. Furthermore, it was shown to inhibit lipid peroxidation initiated by Fe^<2+>/ascorbic acid in rat brain homogenates, and scavenge DPPH radicals. This is the first demonstration of neuroprotective and antioxidant effects of T. farfara. Although complex mechanisms may be involved in the neuroprotective actions, T. farfara may be useful for the management of neurodegenerative disorders associated with inflammation, A_β, excitotoxicity, and/or oxidative stress.
- 公益社団法人日本薬学会の論文
- 2005-03-01
著者
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LEE Yong
Division of Life Sciences, Korea Institute of Science and Technology
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Kim Hyang
Departments of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medici
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Kim Hyang
Department Of Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School Of Medicine
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Jin Changbae
Division Of Life Sciences Korea Institute Of Science & Technology
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JEONG Yeon
College of Pharmacy, Ewha Womans University
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Jeong Yeon
College Of Pharmacy Sookmyung Women's University
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Ryu Jae
College Of Pharmacy Sookmyung Women's University
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CHO Jungsook
Department of Pharmacology, College of Medicine, Dongguk University
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Lee Y
Division Of Life Sciences Korea Institute Of Science & Technology
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Kim Hyang
Department Of Pharmacology College Of Medicine Dongguk University
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Cho Jungsook
Department Of Pharmacology College Of Medicine Dongguk University
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Lee Yong
Division Of Applied Life Science Graduate School Gyeongsang National University
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Ryu Jae-ha
College Of Pharmacy Sookmyung Women's University
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Jeong Yeon
College Of Pharmacy Ewha Womans University
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