Modulation of Radioligand Binding to the GABA_A-benzodiazepine Receptor Complex by a New Component from Cyperus Rotundus
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概要
- 論文の詳細を見る
Four sesquiterpenes, β-selinene, isocurcumenol, nootkatone and aristolone and one triterpene, oleanolic acid were isolated from the ethylacetate fraction of the rhizomes of Cyperus rotundus and tested for their ability to modulate γ-aminobutyric acid(GABA_A)-benzodiazepine receptor function by radioligand binding assays using rat cerebrocortical membranes. Among these compounds, only isocurcumenol, one of the newly identified constituents of this plant, was found to inhibit[^3H]Ro15-1788 binding and enhance[^3H]flunitrazepam binding in the presence of GABA. These results suggest that isocurcumenol may serve as a benzodiazepine receptor agonist and allosterically modulate GABAergic neurotransmission via enhancement of endogenous receptor ligand binding.
- 公益社団法人日本薬学会の論文
- 2002-01-01
著者
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Ha J‐h
Yeungnam Univ. Taegu Kor
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Park J
Pusan National Univ. Pusan Kor
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HA Jeoung-Hee
Department of Pharmacology. School of Medicine, Kyungpook National University
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Park Jong
Department Of Pharmacology College Of Medicine Yeungnam University
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CHO Jungsook
Department of Pharmacology, College of Medicine, Dongguk University
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Lim Jae
College Of Pharmacy Pusan National University
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LIM Jae-Chul
College of Pharmacy, Pusan National University
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LEE Kwang-Youn
Department of Pharmacology, College of Medicine, Yeungnam University
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CHOI Hyoung-Chul
Department of Pharmacology, College of Medicine, Yeungnam University
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KANG Byung-Soo
College of Medicine, Department of Herbal Medicine, College of Natural Science, Dongguk University
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LEE Dong-Ung
College of Oriental Medicine, and Department of Biochemistry, College of Natural Science, Dongguk Un
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Koo Byung
Department Of Oriental Neuropsychiatry College Of Oriental Medicine Dongguk University
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Lee Dong
Department Of Biotechnology College Of Natural Science Dongguk University
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Koo B‐s
Dongguk Univ. Seoul Kor
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Choi Hyoung-chul
Department Of Pharmacology College Of Medicine Yeungnam University
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Lim J‐c
Pusan National Univ. Pusan Kor
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Lee Dong-ung
Dep. Of Biotechnology Dongguk Univ.
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Cho Jungsook
Department Of Pharmacology College Of Medicine Dongguk University
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Cho Jungsook
Department Of Pharmacology College Ofnatural Science Dongguk University
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Ha Jeoung-hee
Department Of Pharmacology School Of Medicine Kyungpook National University
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Lee Kwang-youn
Department Of Pharmacology College Of Medicine Yeungnam University
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Lee Dong-ung
College Of Natural Science Dongguk University
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Ha Jeoung-hee
Department Of Pharmacology Kyungpook National University School Of Medicine
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