Inhibitory Effects of the Fragrance Inhalation of Essential Oil from Acorus gramineus on Central Nervous System

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概要

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• The present study was designed to evaluate central inhibitory effects of the essential oil from Acori graminei Rhizoma (AGR), the dry rhizomes of Acorus gramineus SOLANDER (Araceae) upon fragrance inhalation (aroma therapy). Preinhalation of the oil markedly delayed the appearance of pentylenetetrazole-induced convulsion. Furthermore, inhalation impressively inhibited the activity of r-aminobutyric acid (GABA) transaminase, a degrading enzyme for GABA as the inhalation period was lengthened. The GABA level was significantly increased and glutamate content was significantly decreased in mouse brain by preinhalation of the essential oil. The above results suggest that the anticonvulsive effect of this AGR oil is originated by the enhancement of GABA level in the mouse brain, because convulsion depends partially on GABA concentration which can be properly preserved by inhibiting GABA transaminase. Moreover, fragrance inhalation progressively prolonged the pentobarbital-induced sleeping time as inhalation time was lengthened. Ten hour inhalation corresponded almost to the effect (145% increase) of oral administration (60 mg/kg). This sedative effect after inhalation or oral administration of AGR essential oil suggests that this oil may act on the CNS via the GABAergic system. The inhibitory activity of preinhalation of the essential oil on lipid peroxidation, to which the anticonvulsive action is attributed, also supported the above results, confirming and amplifying our previous reports on the CNS inhibitory effects of AGR.

• 公益社団法人日本薬学会の論文
• 2003-07-01

著者

• Ha J‐h

  Yeungnam Univ. Taegu Kor

• Park J

  Pusan National Univ. Pusan Kor

• HA Jeoung-Hee

  Department of Pharmacology. School of Medicine, Kyungpook National University

• Park Jong

  Department Of Pharmacology College Of Medicine Yeungnam University

• Park Jong

  College Of Pharmacy Pusan National University

• KOO Byung-Soo

  Department of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University

• LEE Dong-Ung

  Department of Biotechnology, College of Natural Science, Dongguk University

• Lim Jae

  College Of Pharmacy Pusan National University

• PARK Kyung-Su

  Department of Oriental Neuropsychiatry, College of Oriental Medicine, Dongguk University

• LIM Jae-Chul

  College of Pharmacy, Pusan National University

• Koo Byung

  Department Of Oriental Neuropsychiatry College Of Oriental Medicine Dongguk University

• Lee Dong

  Department Of Biotechnology College Of Natural Science Dongguk University

• Lee Dong-ung

  Department Of Biochemistry Dongguk University

• Koo B‐s

  Dongguk Univ. Seoul Kor

• Lim J‐c

  Pusan National Univ. Pusan Kor

• Lee Dong-ung

  Dep. Of Biotechnology Dongguk Univ.

• Park Kyung-su

  Department Of Oriental Neuropsychiatry College Of Oriental Medicine Dongguk University

• Park Kyung-su

  Department Of Mechanical Engineering Korea Maritime University

• Ha Jeoung-hee

  Department Of Pharmacology School Of Medicine Kyungpook National University

• Ha Jeoung-hee

  Department Of Pharmacology Kyungpook National University School Of Medicine

• Koo Byung-Soo

  Department of Neuropsychiatry, Graduate School of Oriental Medicine, Dongguk University

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