In Vivo Characterization of Sedative Activities of Fossilia Mastodi OSSIS(Pharmacognosy)
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概要
- 論文の詳細を見る
Fossilia Mastodi Ossis, which is a skeletal fossil of a Mastodon, an ancient mammal, has been found to have anxiolytic, sedative and anticonvulsant activities in Oriental medicine. In this study, in vivo characterization of the sedative activities of Fossilia Mastodi OSSIS was performed in order to obtain basic information for the development of a putative natural sedative. The 80% methanol extract of Fossilia Mastodi OSSIS given per os at a dose of 3g/kg in mice showed anxiolysis, potentiation of pentobarbital sleeping time, reduced locomotor activity, and anticonvulsive activity. Fossilia elicited GABA_A receptor-mediated anxiolysis. The data obtained suggest that the 80% methanol extract of Fossilia Mastodi OSSIS contains some biologically active principles with sedative activity.
- 社団法人日本薬学会の論文
- 2006-07-01
著者
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LEE Maan-Gee
Department of Pharmacology, School of Medicine, Kyungpook National University
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Lee Maan-gee
Department Of Pharmacology. School Of Medicine Kyungpook National University
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Lee Maan-gee
Department Of Pharmacology School Of Medicine Kyungpook National University
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Lee Jae-tae
Department Of Nuclear Medicine School Of Medicine Kyungpook National University
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HA Jeoung-Hee
Department of Pharmacology. School of Medicine, Kyungpook National University
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CHANG Soo-Min
Department of Pharmacology, School of Medicine, Kyungpook National University
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LEE Jae-Tae
Nuclear Medicine, School of Medicine, Kyungpook National University
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Ha Jeoung-hee
Department Of Pharmacology. School Of Medicine Kyungpook National University
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Lee Jae-tae
Nuclear Medicine School Of Medicine Kyungpook National University
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Ha Jeoung-hee
Department Of Pharmacology School Of Medicine Kyungpook National University
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Chang Soo-min
Department Of Pharmacology School Of Medicine Kyungpook National University
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Ha Jeoung-hee
Department Of Pharmacology Kyungpook National University School Of Medicine
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